Project Details
| Status | Finished |
|---|---|
| Effective start/end date | 1/10/20 → 1/10/24 |
Funding
- Aligning Science Across Parkinson's (ASAP) (ASAP-000463): £7,255,503.49
- Michael J. Fox Foundation for Parkinson's Research (ASAP-024403): £1,032,435.25
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
Datasets
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Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Khan, S. (Creator), Sobu, Y. (Creator), Pfeffer, S. (Creator), Dhekne, H. (Creator), Tonelli, F. (Creator), Berndsen, K. (Creator) & Alessi, D. (Creator), Dryad, 1 Nov 2021
DOI: 10.5061/dryad.76hdr7sxx, https://datadryad.org/stash/dataset/doi:10.5061/dryad.76hdr7sxx
Dataset
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Updated: Data upload for Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples
Saarela, D. (Creator), Lis, P. (Creator), Gomes Moreira, S. (Creator), Nirujogi, R. (Creator), Dong, W. (Creator), Rawat, E. (Creator), Glendinning, S. (Creator), Zeneviciute, K. (Creator), Bagnoli, E. (Creator), Fasimoye, R. (Creator), Lin, C. (Creator), Nyame, K. (Creator), Boros, F. A. (Creator), Zunke, F. (Creator), Lamoliatte, F. (Creator), Elshani, S. (Creator), Jaconelli, M. (Creator), Jans, J. (Creator), Huisman, M. A. (Creator), Posern, C. (Creator), Westermann, L. (Creator), Schulz, A. (Creator), van Hasselt, P. (Creator), Alessi, D. (Creator), Abu-Remaileh, M. (Creator) & Sammler, E. (Creator), Zenodo, 21 Oct 2024
DOI: 10.5281/zenodo.11085341, https://zenodo.org/records/13946597
Dataset
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Data upload for Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples
Saarela, D. (Creator), Lis, P. (Creator), Dong, W. (Creator), Rawat, E. (Creator), Fasimoye, R. (Creator), Bagnoli, E. (Creator), Nirujogi, R. (Creator), Jaconelli, M. (Creator), Gomes Moreira, S. (Creator), Zeneviciute, K. (Creator), Jans, J. (Creator), van Hasselt, P. (Creator), Westermann, L. (Creator), Schulz, A. (Creator), Posern, C. (Creator), Boros, F. A. (Creator), Huisman, M. A. (Creator), Glendinning, S. (Creator), Zunke, F. (Creator), Alessi, D. (Creator), Abu-Remaileh, M. (Creator) & Sammler, E. (Creator), Zenodo, 15 Jul 2024
DOI: 10.5281/zenodo.11085341, https://zenodo.org/records/11085342
Dataset
Activities
- 1 Public engagement and outreach - public lecture/debate/seminar
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RSE Curious Festival: The quest to cure Parkinson's
Sammler, E. (Speaker), Muqit, M. (Speaker), Liu, X. (Speaker) & Hawdon, B. (Speaker)
15 Sept 2023Activity: Other activity types › Public engagement and outreach - public lecture/debate/seminar
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Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Bagnoli, E., Lin, Y.-E., Burel, S., Jaimon, E., Antico, O., Themistokleous, C., Nikoloff, J. M., Squires, S., Morella, I., Watzlawik, J. O., Fiesel, F. C., Springer, W., Tonelli, F., Lis, P., Brooks, S. P., Dunnett, S. B., Brambilla, R., Alessi, D. R., Pfeffer, S. R. & Muqit, M. M. K. (Lead / Corresponding author), 4 Feb 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 5, 12 p., e2412029122.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Link opens in a new tab Citations (Scopus)99 Downloads (Pure) -
PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson's disease
Chiang, C. Y., Pratuseviciute, N., Lin, Y.-E., Adhikari, A., Yeshaw, W. M., Flitton, C., Sherpa, P. L., Tonelli, F., Rektorova, I., Siuda, J., Lynch, T., Rudzińska-Bar, M., Pulyk, O., Bauer, P., Beetz, C., Dickson, D. W., Ross, O. A., Wszolek, Z. K., Global Parkinson's Genetics Program (GP2) & Fang, Z.-H. & 5 others, , 26 Aug 2025, In: Cell Reports. 44, 8, 19 p., 116031.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Link opens in a new tab Citations (Scopus)4 Downloads (Pure) -
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif
Waschbüsch, D., Pal, P. (Lead / Corresponding author), Nirujogi, R. S., Cavin, M., Singh, J., Alessi, D. R. (Lead / Corresponding author) & Khan, A. R. (Lead / Corresponding author), 27 Nov 2025, (E-pub ahead of print) In: Structure.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)9 Downloads (Pure)