BACE1 and Endothelial Dysfunction in Diabetes (Project Grant scheme)

Ashford, Michael (Investigator)
Khan, Faisel (Investigator)

8 results

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2021
Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress
Al-Mubarak, B. R., Bell, K. F. S., Chowdhry, S., Meakin, P. J., Baxter, P. S., McKay, S., Dando, O., Ashford, M. L. J., Gazaryan, I., Hayes, J. D. & Hardingham, G. E. (Lead / Corresponding author), Nov 2021, In: Redox Biology. 47, 6 p., 102158.
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2020
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
Meakin, P. J. (Lead / Corresponding author), Coull, B. M., Tuharska, Z., McCaffery, C., Akoumianakis, I., Antoniades, C., Brown, J., Griffin, K. J., Platt, F., Ozber, C. H., Yuldasheva, N. Y., Makava, N., Skromna, A., Prescott, A. R., McNeilly, A. D., Siddiqui, M. K., Palmer, C. N. A., Khan, F. & Ashford, M. L. J. (Lead / Corresponding author), 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4104-4117 14 p.
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2018
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
Meakin, P. J., Jalicy, S. M., Montagut , G., Allsop, D. J. P., Cavellini, D. L., Irvine, S. W., McGinley, C., Liddell, M. K., McNeilly, A. D., Parmionova, K., Liu, Y.-R., Bailey, C. S. L., Dale, J. K., Heisler, L. K., McCrimmon, R. J. & Ashford, M. L. J., 8 Jan 2018, In: Scientific Reports. 8, 1, p. 55 16 p., 55.
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G. & Booty, L. M. & 15 others, Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sévin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. & O'Neill, L. A. (Lead / Corresponding author), 5 Apr 2018, In: Nature. 556, 7699, p. 113-117 5 p.
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Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology
Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A. & Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30 Apr 2018, In: Clinical Science. 132, 8, p. 851-868 18 p.
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The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
Botteri, G., Salvadó, L., Gumà, A., Hamilton, D. L., Meakin, P. J., Montagut , G., Ashford, M. L. J., Ceperuelo-Mallafré, V., Fernández-Veledo, S., Vendrell, J., Calderón-Dominguez, M., Serra, D., Herrero, L., Pizarro, J., Barroso, E., Palomer, X. & Vázquez-Carrera, M. (Lead / Corresponding author), Aug 2018, In: Metabolism. 85, p. 59-75 17 p.
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The beta secretase BACE1 regulates the expression of the insulin receptor in the liver
Meakin, P., Mezzapesa, A., Benabou, E., Haas, M., Bonardo, B., Grino, M., Brunel, J.-M., Biddinger, S. B., Desbois-Mouthon, C., Govers, R., Ashford, M. L. J. & Peiretti, F. (Lead / Corresponding author), 3 Apr 2018, In: Nature Communications. 9, p. 1-14 14 p., 1306.
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2015
BACE1 activity as a determining factor in atherosclerosis development?
Meakin, P., Hamilton, A., Jalicy, S., Khan, F. & Ashford, M., Jul 2015, In: Atherosclerosis. 241, 1, p. e13 1 p., EAS-0263.
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BACE1 and Endothelial Dysfunction in Diabetes (Project Grant scheme)

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2015