Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

Muqit, Miratul (Investigator)

MRC PPU

Project Details

Status	Active
Effective start/end date	1/07/13 → 30/06/23

Funding

Wellcome Trust (210753/Z/18/Z): £2,088,664.00
Wellcome Trust (101022/Z/13/Z): £1,881,328.00

Research Output

10 Article
1 Review article

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg, S., Mulholland, K., Brauning, B., Kacharia, N., Lai, Y-C., Toth, R., Singh, P. K., Volpi, I., Sattler, M., Groll, M., Itzen, A. & Muqit, M. M. K., 11 May 2020, In : Biochemical Journal. 477, 9, p. 1651-1668 18 p.

Research output: Contribution to journal › Article

Open Access

File

14 Downloads (Pure)

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease

Miller, S. & Muqit, M. M. K., 13 Jul 2019, In : Neuroscience Letters. 705, p. 7-13 7 p.

Research output: Contribution to journal › Review article

Open Access

File

11 Citations (Scopus)

99 Downloads (Pure)

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

Research output: Contribution to journal › Article

Open Access

File

11 Citations (Scopus)

146 Downloads (Pure)