Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

Research Outputs

Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease

Research output: Contribution to journal › Review article

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

Research output: Contribution to journal › Article

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Research output: Contribution to journal › Article

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Research output: Contribution to journal › Article

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

Research output: Contribution to journal › Article

TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

Research output: Contribution to journal › Article

A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterisation

Research output: Contribution to journal › Article

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Research output: Contribution to journal › Article

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine⁶⁵

Research output: Contribution to journal › Article

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

Research output: Contribution to journal › Article