Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

Project Details

StatusActive
Effective start/end date1/07/1330/06/23

Funding

  • Wellcome Trust (210753/Z/18/Z): £2,088,664.00
  • Wellcome Trust (101022/Z/13/Z): £1,881,328.00

Research Output

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72

Vieweg, S., Mulholland, K., Brauning, B., Kacharia, N., Lai, Y-C., Toth, R., Singh, P. K., Volpi, I., Sattler, M., Groll, M., Itzen, A. & Muqit, M. M. K., 11 May 2020, In : Biochemical Journal. 477, 9, p. 1651-1668 18 p.

Research output: Contribution to journalArticle

Open Access
File
  • 14 Downloads (Pure)

    Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease

    Miller, S. & Muqit, M. M. K., 13 Jul 2019, In : Neuroscience Letters. 705, p. 7-13 7 p.

    Research output: Contribution to journalReview article

    Open Access
    File
  • 11 Citations (Scopus)
    99 Downloads (Pure)

    The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

    Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 11 Citations (Scopus)
    146 Downloads (Pure)