Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)

Chan, Kwok Ho (Investigator)
Ciulli, Alessio (Investigator)

Status	Finished
Effective start/end date	1/10/15 → 30/09/17

Funding

COMMISSION OF THE EUROPEAN COMMUNITIES (655516): £133,642.00

2 Article
1 Review article

Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A. (Lead / Corresponding author), 25 Jan 2018, In: Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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169 Citations (Scopus)

361 Downloads (Pure)
Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A. (Lead / Corresponding author), May 2017, In: Nature Chemical Biology. 13, 5, p. 514-521 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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796 Citations (Scopus)

651 Downloads (Pure)
Chemical genetics approaches for selective intervention in epigenetics
Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A. (Lead / Corresponding author), Aug 2016, In: Current Opinion in Chemical Biology. 33, p. 186-194 9 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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22 Citations (Scopus)

265 Downloads (Pure)