Bump-BET; Bump and Hole Approach to Ellucidate Function of Individual Bromodomains of BET Proteins (Marie Curie Fellowship)

Chan, Kwok Ho (Investigator)
Ciulli, Alessio (Investigator)

2 Article
1 Review article

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2018
Impact of target warhead and linkage vector on inducing protein degradation: comparison of Bromodomain and Extra-Terminal (BET) degraders derived from triazolodiazepine (JQ1) and tetrahydroquinoline (I-BET726) BET inhibitor scaffolds
Chan, K. H., Zengerle, M., Testa, A. & Ciulli, A. (Lead / Corresponding author), 25 Jan 2018, In: Journal of Medicinal Chemistry. 61, 2, p. 504-513 10 p.
Research output: Contribution to journal › Article › peer-review

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179 Citations (Scopus)

396 Downloads (Pure)
2017
Structural basis of PROTAC cooperative recognition for selective protein degradation
Gadd, M., Testa, A., Lucas, X., Chan, K. H., Chen, W., Lamont, D., Zengerle, M. & Ciulli, A. (Lead / Corresponding author), May 2017, In: Nature Chemical Biology. 13, 5, p. 514-521 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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869 Citations (Scopus)

723 Downloads (Pure)