Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

Project Details

StatusFinished
Effective start/end date1/04/1331/03/18

Funding

  • Medical Research Council (MR/K000985/1): £1,456,163.00

Research Output

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β

Bakshi, S., Taylor, J., Strickson, S., Macartney, T. & Cohen, P., 15 Mar 2017, In : Biochemical Journal. 474, 7, p. 1163-1174 12 p.

Research output: Contribution to journalArticle

Open Access
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  • 20 Citations (Scopus)
    304 Downloads (Pure)

    Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

    Darling, N. J., Toth, R., Arthur, J. S. C. & Clark, K., 3 Feb 2017, In : Biochemical Journal. 474, 4, p. 521-537 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 16 Citations (Scopus)
    191 Downloads (Pure)

    Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation

    McGuire, V. A., Ruiz-Zorrilla Diez, T., Emmerich, C. H., Strickson, S., Ritorto, M. S., Sutavani, R. V., Weiβ, A., Houslay, K. F., Knebel, A., Meakin, P. J., Phair, I. R., Ashford, M. L. J., Trost, M. & Arthur, J. S. C., 8 Aug 2016, In : Scientific Reports. 6, p. 1-17 17 p., 31159.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 38 Citations (Scopus)
    312 Downloads (Pure)