Combined Genetic and Biochemical Approaches to Uncover and Characterize Redundant Factors Involved in Late Stages of Recombinational Repair

Research output

Research output per year 2009 2010 2011 2012 2013 2014 2015 2021

• 28 Article
• 1 Chapter (peer-reviewed)
• 1 Comment/debate
• 1 Editorial
• 2 More
  • 1 Letter
  • 1 Review article

Research output per year

Research output per year

Search results

• 2021

  C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation

  Meier, B., Volkova, N. V., Wang, B., González-Huici, V., Bertolini, S., Campbell, P. J., Gerstung, M. (Lead / Corresponding author) & Gartner, A. (Lead / Corresponding author), 6 Oct 2021, In: PLoS ONE. 16, 10, 23 p., e0258269.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ionizing Radiation 100%
  • Caenorhabditis Elegans 100%
  • Genome Integrity 100%
  • Genome-wide Analysis 100%
  • DNA Repair Pathways 100%
  148 Downloads (Pure)

• Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation

  Meier, B. (Lead / Corresponding author), Volkova, N. V. (Lead / Corresponding author), Hong, Y., Bertolini, S., González-Huici, V., Petrova, T., Boulton, S., Campbell, P. J., Gerstung, M. & Gartner, A., 27 Apr 2021, In: PLoS ONE. 16, 4, 30 p., e0250291.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutagenesis 100%
  • Germ Cells 100%
  • Caenorhabditis Elegans 100%
  • DNA Repair Pathways 100%
  • DNA Repair 100%
  17 Citations (Scopus)

  103 Downloads (Pure)
• 2018

  6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

  Offenburger, S.-L. (Lead / Corresponding author) & Gartner, A., 20 Sept 2018, In: Bio-Protocol. 8, 18, 12 p., e3025.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oxidative Stress 100%
  • Caenorhabditis Elegans 100%
  • Oxidative Stress Markers 100%
  • 6-hydroxydopamine (6-OHDA) 100%
  • Dopaminergic Neuron Loss 100%
  242 Downloads (Pure)
• 2016

  E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

  Ackermann, L., Schell, M., Pokrzywa, W., Kevei, É., Gartner, A., Schumacher, B. (Lead / Corresponding author) & Hoppe, T. (Lead / Corresponding author), Nov 2016, In: Nature Structural & Molecular Biology. 23, 11, p. 995-1002 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Enzyme 100%
  • DNA Damage 100%
  • Ubiquitination 100%
  • Ligase 100%
  • Apoptosis 100%
  31 Citations (Scopus)

  978 Downloads (Pure)

• Micro-proteomics with iterative data analysis: proteome analysis in C.elegans at the single worm level

  Bensaddek, D., Narayan, V., Nicolas, A., Brenes Murillo, A., Gartner, A., Kenyon, C. & Lamond, A. (Lead / Corresponding author), 10 Feb 2016, In: Proteomics. 16, 3, p. 381-392

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Between-person 100%
  • Proteomics 100%
  • Proteomic Analysis 100%
  • Caenorhabditis Elegans 100%
  • Worm 100%
  31 Citations (Scopus)

  196 Downloads (Pure)
• 2015

  Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

  Sonneville, R., Craig, G., Labib, K., Gartner, A. (Lead / Corresponding author) & Blow, J. J. (Lead / Corresponding author), 21 Jul 2015, In: Cell Reports. 12, 3, p. 405-417 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Replication 100%
  • Caenorhabditis Elegans 100%
  • Chromosome Condensation 100%
  • Chromosome Decondensation 100%
  • DNA Synthesis 100%
  26 Citations (Scopus)

  281 Downloads (Pure)

• Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

  Shlien, A. (Lead / Corresponding author), Campbell, B. B., De Borja, R., Alexandrov, L. B., Merico, D., Wedge, D., Van Loo, P., Tarpey, P. S., Coupland, P., Behjati, S., Pollett, A., Lipman, T., Heidari, A., Deshmukh, S., Avitzur, N., Meier, B., Gerstung, M., Hong, Y., Merino, D. M. & Ramakrishna, M. & 31 others, Remke, M., Arnold, R., Panigrahi, G. B., Thakkar, N. P., Hodel, K. P., Henninger, E. E., Göksenin, A. Y., Bakry, D., Charames, G. S., Druker, H., Lerner-Ellis, J., Mistry, M., Dvir, R., Grant, R., Elhasid, R., Farah, R., Taylor, G. P., Nathan, P. C., Alexander, S., Ben-Shachar, S., Ling, S. C., Gallinger, S., Constantini, S., Dirks, P., Huang, A., Scherer, S. W., Grundy, R. G., Durno, C., Aronson, M., Gartner, A. & for the Biallelic Mismatch Repair Deficiency Consortium, 2 Feb 2015, In: Nature Genetics. 47, 3, p. 257-262 6 p.

  Research output: Contribution to journal › Letter › peer-review

  • Somatic mutation 100%
  • DNA Repair Genes 100%
  • Biallelic Mismatch Repair Deficiency 100%
  • Replication Error 100%
  • Hereditary mutations 100%
  296 Citations (Scopus)

• Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

  Liu, Y., Freeman, A. D. J., Déclais, A. C., Wilson, T. J., Gartner, A. & Lilley, D. M. J. (Lead / Corresponding author), 22 Dec 2015, In: Cell Reports. 13, 11, p. 2565-2575 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Structures 100%
  • Four-way Junction 100%
  • Enzyme 100%
  • Crystal Structure 100%
  • Reconnection 50%
  38 Citations (Scopus)

  166 Downloads (Pure)

• Global proteomics analysis of the response to starvation in C. elegans

  Larance, M., Pourkarimi, E., Wang, B., Brenes Murillo, A., Kent, R., Lamond, A. I. (Lead / Corresponding author) & Gartner, A. (Lead / Corresponding author), 1 Jul 2015, In: Molecular & Cellular Proteomics. 14, 7, p. 1989-2001 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Starvation 100%
  • Proteomic Analysis 100%
  • Caenorhabditis Elegans 100%
  • Global Proteomics 100%
  • Proteomics 100%
  34 Citations (Scopus)

  234 Downloads (Pure)
• 2014

  C. elegans whole genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

  Meier, B., Cooke, S. L., Weiss, J., Bailly, A. P., Alexandrov, L. B., Marshall, J., Raine, K., Maddison, M., Anderson, E., Stratton, M. R., Gartner, A. (Lead / Corresponding author) & Campbell, P. J. (Lead / Corresponding author), Oct 2014, In: Genome Research. 24, p. 1624-1636 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Carcinogen 100%
  • Caenorhabditis Elegans 100%
  • Whole Genome Sequencing 100%
  • Mutational Signatures 100%
  • DNA Repair Deficiency 100%
  136 Citations (Scopus)

• Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

  Pelisch, F., Sonneville, R., Pourkarimi, E., Agostinho, A., Blow, J. J., Gartner, A. & Hay, R. T. (Lead / Corresponding author), 5 Dec 2014, In: Nature Communications. 5, 12 p., 5485.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • Caenorhabditis Elegans 100%
  • Cell Cycle Progression 100%
  • Small Ubiquitin-like Modifier 100%
  • Mitotic Chromosome Assembly 100%
  51 Citations (Scopus)

  49 Downloads (Pure)

• GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymes

  Freeman, A. D. J., Liu, Y., Déclais, A.-C., Gartner, A. & Lilley, D. M. J. (Lead / Corresponding author), 12 Dec 2014, In: Journal of Molecular Biology. 426, 24, p. 3946-3959 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thermophilic Fungi 100%
  • Order of Magnitude 50%
  • Recombination 50%
  • Amino Acids 50%
  • Phage 50%
  17 Citations (Scopus)

  253 Downloads (Pure)

• Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing

  Meier, B. & Gartner, A. (Lead / Corresponding author), 15 Nov 2014, In: Experimental Cell Research. 329, 1, p. 35-41 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genotoxin 100%
  • DNA Damage 100%
  • DNA Repair 100%
  • Repair Method 100%
  • Next-generation Sequencing 100%
  9 Citations (Scopus)

  220 Downloads (Pure)

• Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans

  Masoudi, N., Ibanez-Cruceyra, P., Offenburger, S.-L., Holmes, A. & Gartner, A. (Lead / Corresponding author), 4 Dec 2014, In: PLoS Genetics. 10, 12, 15 p., e1004767.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Caenorhabditis Elegans 100%
  • Neurodegeneration 100%
  • 6-hydroxydopamine (6-OHDA) 100%
  • Dopaminergic Neurons 100%
  • Tetraspanin 100%
  31 Citations (Scopus)

  212 Downloads (Pure)
• 2013

  Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases

  Agostinho, A., Meier, B., Sonneville, R., Jagut, M., Woglar, A., Blow, J., Jantsch, V. & Gartner, A. (Lead / Corresponding author), 18 Jul 2013, In: PLoS Genetics. 9, 7, e1003591.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis Elegans 100%
  • Nuclease 100%
  • Holliday Junction Resolvase 100%
  • Combinatorial Regulation 100%
  • BLM Helicase 100%
  76 Citations (Scopus)

• RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans

  Akay, A. (Lead / Corresponding author), Craig, A., Lehrbach, N., Larance, M., Pourkarimi, E., Wright, J. E., Lamond, A., Miska, E. & Gartner, A., Nov 2013, In: Open Biology. 3, 130151.

  Research output: Contribution to journal › Article › peer-review

  • RNA-binding Protein 100%
  • Caenorhabditis Elegans 100%
  • GLD-1 100%
  • Let-7 miRNA 100%
  • Mir-35 100%
  17 Citations (Scopus)

• Stress Response: Anything that Doesn't Kill You Makes You Stronger

  Gartner, A. (Lead / Corresponding author) & Akay, A., 18 Nov 2013, In: Current Biology. 23, 22, p. R1012-R1014 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Stress Response 100%
  • Oxidative Stress 100%
  • DNA Damage 100%
  • DNA Repair 100%
  • Response Pathways 100%
  4 Citations (Scopus)

• The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans

  Masoudi, N., Fancsalszky, L., Pourkarimi, E., Vellai, T., Alexa, A., Reményi, A., Gartner, A., Mehta, A. & Takács-Vellai, K., 15 Aug 2013, In: Development. 140, 16, p. 3486-3495 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitogen-activated Protein Kinase 100%
  • Caenorhabditis Elegans 100%
  • Ras Signaling 100%
  • Nm23 100%
  • H1-H2 100%
  31 Citations (Scopus)
• 2012

  Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction

  Pourkarimi, E., Greiss, S. & Gartner, A., Mar 2012, In: Cell Death & Differentiation. 19, 3, p. 406-415 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis Elegans 100%
  • Apoptosis Induction 100%
  • B-cell Lymphoma 2 (Bcl-2) 100%
  • CED-4 100%
  • Apoptotic Protease Activating factor-1 100%
  45 Citations (Scopus)

• LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

  Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X. (Lead / Corresponding author), 2012, In: Science. 337, 6092, p. 351-354 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Lysine 100%
  • Arginine Transporter 100%
  • Amino Acid Homeostasis 100%
  • Homeostasis 100%
  • Amino Acids 100%
  130 Citations (Scopus)

• Methods for studying the DNA damage response in the Caenorhabdatis elegans germ line

  Craig, A. L., Moser, S. C., Bailly, A. P. & Gartner, A., 2012, Caenorhabditis elegans: cell biology and physiology. Rothman, J. H. & Singson, A. (eds.). Academic Press, p. 321-352 32 p. (Methods in Cell Biology; vol. 107).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)

  • Germ Cells 100%
  • Caenorhabditis Elegans 100%
  • DNA Damage Response 100%
  • Elegans 100%
  • Germ Cell 100%
  92 Citations (Scopus)

• The dynamics of replication licensing in live Caenorhabditis elegans embryos

  Sonneville, R., Querenet, M., Craig, A., Gartner, A. (Lead / Corresponding author) & Blow, J. J. (Lead / Corresponding author), 23 Jan 2012, In: Journal of Cell Biology. 196, 2, p. 233-246 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Replication Licensing 100%
  • Origin Recognition Complex 100%
  • Caenorhabditis Elegans Embryo 100%
  • Dynamics 100%
  • DNA Synthesis 100%
  59 Citations (Scopus)

  219 Downloads (Pure)

• The shark in us: Learning about the evolution of the p53 regulatory circuit

  Rutkowski, R. & Gartner, A., 15 Jan 2012, In: Cell Cycle. 11, 2, p. 216-217 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  1 Citation (Scopus)
• 2011

  CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

  Franz, A., Orth, M., Pirson, P. A., Sonneville, R., Blow, J. J., Gartner, A., Stemmann, O. & Hoppe, T., 7 Oct 2011, In: Molecular Cell. 44, 1, p. 85-96 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Replication 100%
  • Dissociation 100%
  • Chromatin 100%
  • Cdc48 100%
  • DNA Synthesis 100%
  77 Citations (Scopus)

• Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

  Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A. (Lead / Corresponding author), Aug 2011, In: PLoS Genetics. 7, 8, p. - 21 p., e1002238.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis Elegans 100%
  • Germ Cell Apoptosis 100%
  • CEP-1 100%
  • RAS-MAPK Signaling 100%
  • MAPK Signaling 100%
  61 Citations (Scopus)

• Stable-isotope labeling with amino acids in nematodes

  Larance, M., Bailly, A. P., Pourkarimi, E., Hay, R. T., Buchanan, G., Coulthurst, S., Xirodimas, D. P., Gartner, A. (Lead / Corresponding author) & Lamond, A. I. (Lead / Corresponding author), Oct 2011, In: Nature Methods. 8, 10, p. 849-851 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Nematodes 100%
  • Amino Acids 100%
  • Worm 100%
  • Arginine 100%
  • Stable Isotope Labeling 100%
  99 Citations (Scopus)
• 2010

  Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1

  Ito, S., Greiss, S., Gartner, A. & Derry, W. B., 23 Feb 2010, In: Current Biology. 20, 4, p. 333-338 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Death 100%
  • Germ Cells 100%
  • Caenorhabditis Elegans 100%
  • Non-cell Autonomous 100%
  • DNA Damage 50%
  45 Citations (Scopus)

• Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

  MacKay, C., Declais, A.-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J. (Lead / Corresponding author), 9 Jul 2010, In: Cell. 142, 1, p. 65-76 12 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA Damage 100%
  • DNA Repair 100%
  • Nuclease 100%
  • FANCD2 100%
  • FAN1 100%
  251 Citations (Scopus)

• Phylogeny and Function of the Invertebrate p53 Superfamily

  Rutkowski, R., Hofmann, K. & Gartner, A., Jul 2010, In: Cold spring harbor perspectives in biology. 2, 7, p. - 13 p., a001131.

  Research output: Contribution to journal › Article › peer-review

  • Phylogeny 100%
  • Invertebrates 100%
  • P53 100%
  • Cladistics 100%
  • Apoptosis 66%
  90 Citations (Scopus)

• Tagging the dead: a bridging factor for Caenorhabditis elegans phagocyte receptors

  Rutkowski, R. & Gartner, A., Jul 2010, In: Nature Cell Biology. 12, 7, p. 638-640 4 p.

  Research output: Contribution to journal › Editorial › peer-review

  • Caenorhabditis Elegans 100%
  • Apoptotic Cells 100%
  • Phagocytic Cells 100%
  • Bridging Factors 100%
  • Phagocytes 100%
  1 Citation (Scopus)

• The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

  Bailly, A. P., Freeman, A., Hall, J., Declais, A.-C., Alpi, A., Lilley, D. M. J., Ahmed, S. & Gartner, A. (Lead / Corresponding author), Jul 2010, In: PLoS Genetics. 6, 7, p. - 16 p., e1001025.

  Research output: Contribution to journal › Article › peer-review

  • Caenorhabditis Elegans 100%
  • DNA Double-strand Break Repair 100%
  • Yen1 100%
  • DNA Damage Signaling 100%
  • Resolvase 100%
  76 Citations (Scopus)

• The Caenorhabditis elegans Werner Syndrome Protein functions upstream of ATR and ATM in response to DNA Replication Inhibition and Double-Strand DNA Breaks

  Lee, S.-J., Gartner, A., Hyun, M., Ahn, B. & Koo, H.-S., Jan 2010, In: PLoS Genetics. 6, 1, p. - 11 p., e1000801.

  Research output: Contribution to journal › Article › peer-review

  • DNA Replication 100%
  • Caenorhabditis Elegans 100%
  • DNA Double-strand Breaks 100%
  • Protein Function 100%
  • Viral Inhibition 100%
  48 Citations (Scopus)
• 2009

  Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

  Greiss, S. & Gartner, A., Nov 2009, In: Molecules and Cells. 28, 5, p. 407-415 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Phylogeny 100%
  • Sirtuins 100%
  • Structural Conservation 100%
  • Sir2 100%
  • Evolutionary Considerations 100%
  175 Citations (Scopus)