Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

Dinkova-Kostova, Albena (Investigator)
Hayes, John (Investigator)
Henderson, Colin (Investigator)
Keyse, Stephen (Investigator)
Lamond, Angus (Investigator)
Sutherland, Calum (Investigator)

7 Article
4 Review article

11 results

2020
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis
Robertson, H., Dinkova-Kostova, A. T. & Hayes, J. D. (Lead / Corresponding author), 2 Dec 2020, In: Cancers. 12, 12, 48 p., 3609.
Research output: Contribution to journal › Review article › peer-review

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66 Citations (Scopus)

255 Downloads (Pure)
Oxidative Stress in Cancer
Hayes, J. (Lead / Corresponding author), Dinkova-Kostova, A. & Tew, K. D., 10 Aug 2020, In: Cancer Cell. 38, 2, p. 167-197 31 p.
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2001 Citations (Scopus)

943 Downloads (Pure)
2019
Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells
Murray, J. R., de la Vega, L., Hayes, J. D., Duan, L. & Penning, T. M. (Lead / Corresponding author), 16 Dec 2019, In: Chemical Research in Toxicology. 32, 12, p. 2538-2551 14 p.
Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus)
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Cuadrado, A., Rojo, A. I., Wells, G., Hayes, J., Cousin, S. P., Rumsey, W. L., Attucks, O. C., Franklin, S., Levonen, A.-L., Kensler, T. W. & Dinkova-Kostova, A. (Lead / Corresponding author), Apr 2019, In: Nature Reviews Drug Discovery. 18, 4, p. 295-317 23 p.
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1130 Citations (Scopus)

1259 Downloads (Pure)
2018
A partnership with the proteasome: the destructive nature of GSK3
Robertson, H., Hayes, J. D. & Sutherland, C. (Lead / Corresponding author), Jan 2018, In: Biochemical Pharmacology. 147, p. 77-92 16 p.
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79 Citations (Scopus)

413 Downloads (Pure)
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Sharma, R. S., Harrison, D. J., Kisielewski, D., Cassidy, D. M., McNeilly, A. D., Gallagher, J. R., Walsh, S. V., Honda, T., McCrimmon, R. J., Dinkova-Kostova, A. T., Ashford, M. L. J., Dillon, J. F. & Hayes, J. D. (Lead / Corresponding author), 1 Mar 2018, In: Cellular and Molecular Gastroenterology and Hepatology. 5, 3, p. 367-398 32 p.
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196 Citations (Scopus)

371 Downloads (Pure)
Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2
McMahon, M. (Lead / Corresponding author), Swift, S. R. & Hayes, J. D. (Lead / Corresponding author), 1 Dec 2018, In: Toxicology and Applied Pharmacology. 360, p. 45-57 13 p.
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38 Citations (Scopus)

469 Downloads (Pure)
2017
Epigenetic Control of NRF2-Directed Cellular Antioxidant Status in Dictating Life-Death Decisions
Hayes, J. D. (Lead / Corresponding author) & Dinkova-Kostova, A. T., 5 Oct 2017, In: Molecular Cell. 68, 1, p. 5-7 3 p.
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24 Citations (Scopus)

399 Downloads (Pure)
Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival
Hayes, J. D. & Dinkova-Kostova, A. T. (Lead / Corresponding author), Nov 2017, In: Cancer Cell. 32, 5, p. 539-541 3 p.
Research output: Contribution to journal › Article › peer-review

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25 Citations (Scopus)

345 Downloads (Pure)
2016
Nrf2-mediated neuroprotection response to recurrent hypoglycemia is insufficient to prevent cognitive impairment in a rodent model of type 1 diabetes
McNeilly, A. D., Gallagher, J. R., Dinkova-Kostova, A. T., Hayes, J. D., Sharkey, J., Ashford, M. L. J. & McCrimmon, R. J. (Lead / Corresponding author), 1 Oct 2016, In: Diabetes. 65, 10, p. 3151-3160 10 p.
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35 Citations (Scopus)

317 Downloads (Pure)
Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP
Hayes, J. D. (Lead / Corresponding author), Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova-Kostova, A. T. & Sutherland, C., Dec 2016, In: Current Opinion in Toxicology. 1, p. 92-103 12 p.
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19 Citations (Scopus)

601 Downloads (Pure)

Contribution by NRF2 Upregulation to Lung Carcinogenesis and the Possible Therapeutic Value of NRF2 Inhibition by GSK-3 (Joint with Universities of St Andrews, Edinburgh and Pennsylvania)

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