De-risking Innovative Drug Discovery Projects through Portfolio Management (Confidence in Concept)

Project Details

StatusFinished
Effective start/end date1/03/1431/08/15

Funding

  • Medical Research Council (MC_PC_13061): £800,000.00

Research Output

Screening of a novel fragment library with functional complexity against Mycobacterium tuberculosis InhA

Prati, F., Zuccotto, F., Fletcher, D., Convery, M. A., Fernandez-Menendez, R., Bates, R., Encinas, L., Zeng, J., Chung, C-W., De Dios Anton, P., Mendoza-Losana, A., Mackenzie, C., Green, S. R., Huggett, M., Barros, D., Wyatt, P. G. & Ray, P. C., 6 Apr 2018, In : ChemMedChem. 13, 7, p. 672-677 6 p.

Research output: Contribution to journalArticle

Open Access
File
  • 133 Downloads (Pure)

    Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

    Martins Da Silva, S. J., Brown, S. G., Sutton, K., King, L. V., Ruso, H., Gray, D. W., Wyatt, P. G., Kelly, M. C., Barratt, C. L. R. & Hope, A. G., May 2017, In : Human Reproduction. 32, 5, p. 974-984 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 7 Citations (Scopus)
    148 Downloads (Pure)

    Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM

    Varshney, D., Petit, A-P., Bueren-Calabuig, J. A., Jansen, C., Fletcher, D. A., Peggie, M., Weidlich, S., Scullion, P., Pisliakov, A. V. & Cowling, V. H., 1 Dec 2016, In : Nucleic Acids Research. 44, 21, p. 10423-10436 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 14 Citations (Scopus)
    341 Downloads (Pure)