Decoding Mechanisms of gene regulation in African Trypanosomes

Research output

Research output per year 2022 2022 2023 2024 2025 2026 2026

• 17 Article
• 3 Review article
• 1 Digital or Visual Products
• 1 Software

Research output per year

Research output per year

Search results

• 2026

  Acoziborole resistance associated mutations in Trypanosoma brucei CPSF3

  Ridgway, M., Novotna, M., Mendoza Martinez, C., Tinti, M., Altmann, S., Sloan, G. & Horn, D. (Lead / Corresponding author), 3 Mar 2026, In: PLoS Pathogens. 22, 3 , 12 p., e1013764.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma Brucei 100%
  • Alternative Polyadenylation 100%
  • Resistance mutations 100%
  • Specificity Factor 100%
  • Acoziborole 100%

  11 Downloads (Pure)

• Decoding efficacy and resistance space at a drug binding site

  Altmann, S., Mendoza Martinez, C., Ridgway, M., Tinti, M., Saini, J., Ibrahim, P. E. G. F., Thomas, M., De Rycker, M., Bodkin, M. J. & Horn, D. (Lead / Corresponding author), 11 Mar 2026, In: Nature Communications. 17, 14 p., 2337.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Codon 100%
  • Drug Binding Site 100%
  • Drug Resistance 66%
  • Multiplex 66%
  • Oligo 66%

  2   Link opens in a new tab Citations (Scopus)

  14 Downloads (Pure)

• Genetic origins and proteomic consequences of kinetoplast loss in trypanosomes

  Ridgway, M., Escrivani, D. O., Novotna, M., Wood, A., Tinti, M., Schnaufer, A. & Horn, D. (Lead / Corresponding author), Mar 2026, In: PLoS Digital Health. 22, 3, 17 p., e1013846.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kinetoplastid 100%
  • Proteomics 100%
  • Trypanosoma 100%
  • Genetic Origin 100%
  • KDNA 100%

  6 Downloads (Pure)

• Zinc-dependent turnover of ZIP3 transporter mRNA by trypanosome ZNK1

  Leão, T., Trenaman, A., Tinti, M., Bravo Ruiz, G., Viegas, I. J., Figueiredo, L. M., Duarte, M., Tomás, A. M. & Horn, D. (Lead / Corresponding author), 12 Sept 2026, In: Nucleic Acids Research. 54, 17, 14 p., gkag877.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Zinc 100%
  • Zinc-dependent 100%
  • Zip3 100%
  • Messenger RNA 100%

• 2025

  A non-coding role for trypanosome VSG transcripts in allelic exclusion

  Escrivani, D. O., Hutchinson, S., Tinti, M., Wright, J. E., Marques, C. A., Faria, J. R. C., Trenaman, A. & Horn, D. (Lead / Corresponding author), 28 Oct 2025, In: Nucleic Acids Research. 53, 19, 16 p., gkaf1011.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Spike Glycoprotein 100%
  • Non-coding 100%
  • Allelic Exclusion 100%
  • Glycoprotein 100%

  16 Downloads (Pure)

• Decoding post-transcriptional gene expression controls in trypanosomatids using machine learning

  Tinti, M. (Lead / Corresponding author) & Horn, D. (Lead / Corresponding author), 9 Jul 2025, In: Wellcome Open Research. 10, 173, 14 p., 173.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 3′-untranslated Region (3′-UTR) 100%
  • Trypanosoma 100%
  • Gene Regulation 100%
  • Translation Quality 100%
  • Post-transcriptional Gene Regulation 100%

  2   Link opens in a new tab Citations (Scopus)

  125 Downloads (Pure)

• mtinti/OligoSeeker: 0.0.6

  Tinti, M. (Creator), 7 May 2025

  Research output: Non-textual form › Software

  Open Access

  • Codon 100%
  • Python Package 100%
  • Zenodo 100%
  • Pythonidae 100%

• Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes

  Novotna, M., Tinti, M., Correia Faria, J. & Horn, D. (Lead / Corresponding author), 4 Jul 2025, In: Nature Communications. 16, 14 p., 6194.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Gene Regulation 100%
  • RNA Polymerase II (RNAPII) 100%
  • Histone H4 100%
  • Histone Tails 100%

  3   Link opens in a new tab Citations (Scopus)

  99 Downloads (Pure)

• 2024

  Genome-wide screens connect HD82 loss-of-function to purine analog resistance in African trypanosomes

  Trenaman, A., Tinti, M., Atrih, A. & Horn, D. (Lead / Corresponding author), Jan 2024, In: mSphere. 9, 1, 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Loss Function 100%
  • Trypanosoma 100%
  • African Trypanosomes 100%
  • Nucleoside Analogues 100%
  • Purine Analogues 100%

  132 Downloads (Pure)

• Pass the boron: benzoxaboroles as antiparasite drugs

  Zoltner, M., Horn, D. & Field, M. (Lead / Corresponding author), Sept 2024, In: Trends in Parasitology. 40, 9, p. 820-828 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Antiparasitic Drugs 100%
  • Boron 100%
  • Benzoxaborole 100%
  • Protozoa 100%
  • Morbidity 100%

  7   Link opens in a new tab Citations (Scopus)

  102 Downloads (Pure)

• Post-transcriptional reprogramming by thousands of mRNA untranslated regions in trypanosomes

  Trenaman, A., Tinti, M., Wall, R. & Horn, D. (Lead / Corresponding author), 16 Sept 2024, In: Nature Communications. 15, 18 p., 8113.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 3′-untranslated Region (3′-UTR) 100%
  • Trypanosoma 100%
  • Post-transcriptional 100%
  • Transcriptional Reprogramming 100%
  • Untranslated Region 100%

  11   Link opens in a new tab Citations (Scopus)

  133 Downloads (Pure)

• The bloodstream form of Trypanosoma brucei displays non-canonical gluconeogenesis

  Kovářová, J. (Lead / Corresponding author), Moos, M., Barrett, M. P., Horn, D. & Zíková, A., Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 19 p., e0012007.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma Brucei 100%
  • Gluconeogenesis 100%
  • Non-canonical 100%
  • Bloodstream Form 100%
  • Enzyme 50%

  3   Link opens in a new tab Citations (Scopus)

  136 Downloads (Pure)

• 2023

  An allele-selective inter-chromosomal protein bridge supports monogenic antigen expression in the African trypanosome

  Correia Faria, J. R. (Lead / Corresponding author), Tinti, M., Marques, C. A., Zoltner, M., Yoshikawa, H., Field, M. C. & Horn, D. (Lead / Corresponding author), 11 Dec 2023, In: Nature Communications. 14, 1, 18 p., 8200.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spike Glycoprotein 100%
  • African Trypanosomes 100%
  • Monogenic 100%
  • Antigen Expression 100%
  • Chromosomal Proteins 100%

  12   Link opens in a new tab Citations (Scopus)

  137 Downloads (Pure)

• Competition among variants is predictable and contributes to the antigenic variation dynamics of African trypanosomes

  Escrivani, D. O., Scheidt, V., Tinti, M., Correia Faria, J. & Horn, D. (Lead / Corresponding author), 17 Jul 2023, In: PLoS Pathogens. 19, 7, 21 p., e1011530.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Spike Glycoprotein 100%
  • African Trypanosomes 100%
  • Antigenic Variation 100%
  • Glycoprotein 100%
  • Trypanosoma 100%

  6   Link opens in a new tab Citations (Scopus)

  143 Downloads (Pure)

• Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

  Bachmaier, S., Gould, M. K., Polatoglou, E., Omelianczyk, R., Brennand, A. E., Aloraini, M. A., Munday, J. C., Horn, D., Boshart, M. (Lead / Corresponding author) & de Koning, H. P. (Lead / Corresponding author), 5 Jul 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 15 p., 1204707.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Kinetoplastid 100%
  • CAMP Receptor Protein 100%
  • Trypanosoma Brucei 100%
  • Trypanosoma 100%
  • Flagellar 100%

  12   Link opens in a new tab Citations (Scopus)

  140 Downloads (Pure)

• Targeting parasites

  Horn, D. (Contributing member), Ridgway, M. (Contributing member), Cameron, A. (Producer) & Soave, S. (Film-maker), 2023

  Research output: Non-textual form › Digital or Visual Products

  • Audio 100%
  • Trypanosoma 100%
  • Wellcome Trust 100%
  • Anti-infective 100%
  • Trust Center 100%

• 2022

  A profile of research on the parasitic trypanosomatids and the diseases they cause

  Horn, D. (Lead / Corresponding author), 13 Jan 2022, In: PLoS Neglected Tropical Diseases. 16, 1, p. 1-23 23 p., e0010040.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Trypanosomatidae 100%
  • Diseases 100%
  • Cell Biology 50%
  • Molecular Biology 50%

  33   Link opens in a new tab Citations (Scopus)

  253 Downloads (Pure)

• Control of variant surface glycoprotein expression by CFB2 in Trypanosoma brucei and quantitative proteomic connections to translation and cytokinesis

  Bravo Ruiz, G., Tinti, M., Ridgway, M. & Horn, D. (Lead / Corresponding author), Apr 2022, In: mSphere. 7, 2, 14 p., e00069-22.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma Brucei 100%
  • Spike Glycoprotein 100%
  • Cytokinesis 100%
  • Quantitative Proteomics 100%
  • F-box Protein 100%

  6   Link opens in a new tab Citations (Scopus)

  307 Downloads (Pure)

• CRISPR/Cas9-based precision tagging of essential genes in bloodstream form African trypanosomes

  Kovářová, J., Novotná, M., Faria, J., Rico, E., Wallace, C., Zoltner, M., Field, M. C. & Horn, D. (Lead / Corresponding author), 10 Apr 2022, In: Molecular and Biochemical Parasitology. 249, 7 p., 111476.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 3′-untranslated Region (3′-UTR) 100%
  • African Trypanosomes 100%
  • Cas9 Protein 100%
  • Bloodstream Form 100%
  • Untranslated Region 100%

  9   Link opens in a new tab Citations (Scopus)

  163 Downloads (Pure)

• Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects

  Marques, C. A., Ridgway, M., Tinti, M., Cassidy, A. & Horn, D. (Lead / Corresponding author), 10 Sept 2022, In: Nature Communications. 13, 16 p., 5326.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA Interference 100%
  • Trypanosoma Brucei 100%
  • Cell Cycle Progression 100%
  • Genome-scale 100%
  • RNAI 100%

  12   Link opens in a new tab Citations (Scopus)

  215 Downloads (Pure)

• Genome-scale RNAi screens in African trypanosomes

  Horn, D. (Lead / Corresponding author), 1 Feb 2022, In: Trends in Parasitology. 38, 2, p. 160-173 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • African Trypanosomes 100%
  • RNA Interference Screen 100%
  • Genome-scale 100%
  • Trypanosoma 100%
  • RNAI 100%

  17   Link opens in a new tab Citations (Scopus)

  347 Downloads (Pure)

• Oligo targeting for profiling drug resistance mutations in the parasitic trypanosomatids

  Altmann, S., Rico, E., Carvalho, S., Ridgway, M., Trenaman, A., Donnelly, H., Tinti, M., Wyllie, S. & Horn, D. (Lead / Corresponding author), 12 Aug 2022, In: Nucleic Acids Research. 50, 14, p. 1-8 8 p., e79.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma 100%
  • Drug Resistance mutations 100%
  • Oligo 100%
  • Drug Resistance 100%
  • Trypanosomatid 100%

  20   Link opens in a new tab Citations (Scopus)

  187 Downloads (Pure)