Research output per year
Research output per year
Project Details
| Status | Finished |
|---|---|
| Effective start/end date | 8/04/13 → 7/04/15 |
Funding
- COMMISSION OF THE EUROPEAN COMMUNITIES (328030): £190,730.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Diehl, C. J. & Ciulli, A. (Lead / Corresponding author), 19 Aug 2022, In: Chemical Society Reviews. 51, 19, p. 8216-8257 42 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile84 Citations (Scopus)232 Downloads (Pure) -
Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
Soares, P., Gadd, M., Frost, J., Galdeano, C., Ellis, L., Epemolu, R., Rocha, S., Read, K. & Ciulli, A. (Lead / Corresponding author), 25 Jan 2018, In: Journal of Medicinal Chemistry. 61, p. 599-618 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile113 Citations (Scopus)329 Downloads (Pure) -
Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition
Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A. (Lead / Corresponding author), 4 Nov 2016, In: Nature Communications. 7, p. 1-12 12 p., 13312.Research output: Contribution to journal › Article › peer-review
Open AccessFile167 Citations (Scopus)308 Downloads (Pure)