Design of Orthogonal Molecular Probes Targeting Engineered Von-Hippel Lindau (VHL) E3 Ubiquitin Ligase for the Control of Intercellular Protein Levels

Project Details

StatusFinished
Effective start/end date8/04/137/04/15

Funding

  • COMMISSION OF THE EUROPEAN COMMUNITIES (328030): £190,730.00

Research Output

Open Access
File
  • 30 Citations (Scopus)
    157 Downloads (Pure)

    Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

    Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 54 Citations (Scopus)
    141 Downloads (Pure)

    Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

    Galdeano, C., Gadd, M. S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D. M. & Ciulli, A., 23 Oct 2014, In : Journal of Medicinal Chemistry. 57, 20, p. 8657-8663 7 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 118 Citations (Scopus)
    221 Downloads (Pure)