Keyphrases
Von Hippel-Lindau
94%
E3 Ubiquitin Ligase
63%
Chemical Probes
63%
Hypoxia-inducible Factor
45%
VH298
43%
E3 Ligase
42%
Small Molecule Ligands
42%
Structure-based Design
41%
Protein-protein Interaction
39%
Proteolysis Targeting chimera (PROTAC)
39%
Hypoxia-inducible factor-1α (HIF-1α)
35%
Alpha Subunit
31%
Hypoxic Signaling
31%
Small Molecule Targeting
31%
Pyrrolidine-2
31%
Structure Optimization
31%
Group-based
31%
Benzyl
31%
Hydroxylation
31%
Carboxamide
31%
Structure-activity Relationship
31%
Degrader
31%
Ubiquitin-proteasome System
23%
Binding Affinity
16%
Ubiquitination
16%
Von Hippel-Lindau Disease
10%
X-ray Crystal Structure
10%
Substrate Recognition
10%
Proteasomal Degradation
10%
Prolyl Hydroxylase Domain
7%
Hydroxylated
7%
Hypoxic Response
7%
Stumbling
6%
Ligand Binding
6%
E3 Ligase Ligands
6%
Field Development
6%
Rationally Designed
6%
Essential Enzymes
6%
Cullin-RING E3 Ligase
6%
New Ligand
6%
Substrate Proteins
6%
Non-native
6%
Bifunctional Molecules
6%
Targeted Protein Degradation
6%
Biochemistry, Genetics and Molecular Biology
Hypoxia-Inducible Factors
100%
Small Molecule
67%
Ubiquitin-Conjugating Enzyme
63%
Ligase
57%
Protein Catabolism
52%
Protein-Protein Interaction
46%
Hypoxia Inducible Factor 1
42%
Structure Activity Relation
31%
Hydroxylation
31%
Alpha Chain
31%
Ubiquitin
26%
Proteasome
26%
Binding Affinity
21%
Ubiquitination
21%
Crystal Structure
15%
X Ray
15%
Enzyme
13%
Dissociation Constant
10%
Tumor Suppressor Protein
10%
Procollagen-Proline Dioxygenase
7%
Cullin
5%
Ligand Binding
5%
Pharmacology, Toxicology and Pharmaceutical Science
Hypoxia Inducible Factor
68%
Ubiquitin Protein Ligase E3
63%
Ligase
57%
Hypoxia Inducible Factor 1
42%
Carboxamide
31%
Pyrrolidine Derivative
31%
Structure Activity Relationship
31%
Von Hippel Lindau Protein
31%
Ubiquitin
26%
Proteasome
26%
Anemia
10%
Ischemia
10%
Tumor Suppressor Protein
10%
Cullin
5%