Keyphrases
Alpha Subunit
31%
Benzyl
31%
Bifunctional Molecules
6%
Binding Affinity
16%
Carboxamide
31%
Chemical Probes
63%
Cullin-RING E3 Ligase
6%
Degrader
31%
E3 Ligase
42%
E3 Ligase Ligands
6%
E3 Ubiquitin Ligase
63%
Essential Enzymes
6%
Field Development
6%
Group-based
31%
Hydroxylated
7%
Hydroxylation
31%
Hypoxia-inducible Factor
45%
Hypoxia-inducible factor-1α (HIF-1α)
35%
Hypoxic Response
7%
Hypoxic Signaling
31%
Ligand Binding
6%
New Ligand
6%
Non-native
6%
Prolyl Hydroxylase Domain
7%
Proteasomal Degradation
10%
Protein-protein Interaction
39%
Proteolysis Targeting chimera (PROTAC)
39%
Pyrrolidine-2
31%
Rationally Designed
6%
Small Molecule Ligands
42%
Small Molecule Targeting
31%
Structure Optimization
31%
Structure-activity Relationship
31%
Structure-based Design
41%
Stumbling
6%
Substrate Proteins
6%
Substrate Recognition
10%
Targeted Protein Degradation
6%
Ubiquitin-proteasome System
23%
Ubiquitination
16%
VH298
43%
Von Hippel-Lindau
94%
Von Hippel-Lindau Disease
10%
X-ray Crystal Structure
10%
Biochemistry, Genetics and Molecular Biology
Alpha Chain
31%
Binding Affinity
21%
Crystal Structure
15%
Cullin
5%
Dissociation Constant
10%
Enzyme
13%
Hydroxylation
31%
Hypoxia Inducible Factor 1
42%
Hypoxia-Inducible Factors
100%
Ligand Binding
5%
Ligase
57%
Procollagen-Proline Dioxygenase
7%
Proteasome
26%
Protein Catabolism
52%
Protein-Protein Interaction
46%
Small Molecule
67%
Structure Activity Relation
31%
Tumor Suppressor Protein
10%
Ubiquitin
26%
Ubiquitin-Conjugating Enzyme
63%
Ubiquitination
21%
X Ray
15%
Pharmacology, Toxicology and Pharmaceutical Science
Anemia
10%
Carboxamide
31%
Cullin
5%
Hypoxia Inducible Factor
68%
Hypoxia Inducible Factor 1
42%
Ischemia
10%
Ligase
57%
Proteasome
26%
Pyrrolidine Derivative
31%
Structure Activity Relationship
31%
Tumor Suppressor Protein
10%
Ubiquitin
26%
Ubiquitin Protein Ligase E3
63%
Von Hippel Lindau Protein
31%