Determining the Role and Mechanism of Action of SUMO Targeted Ubiquitin Ligase RNF4 in Maintaining Genome Integrity (Senior Investigator Award)

Research output

Research output per year 2012 2014 2015 2019 2020 2020

• 38 Article
• 1 Chapter (peer-reviewed)
• 1 Letter

Research output per year

Research output per year

Search results

• 2020

  Antibody RING-Mediated Destruction of Endogenous Proteins

  Ibrahim, A. F. M., Shen, L., Tatham, M. H., Dickerson, D., Prescott, A. R., Abidi, N., Xirodimas, D. P. & Hay, R. T. (Lead / Corresponding author), 2 Jul 2020, In: Molecular Cell. 79, 1, p. 155-166 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Endogenous Protein 100%
  • Immunology 100%
  • Protein 100%
  • Single-Domain Antibody 100%
  • Rapid Degradation 66%
  34 Citations (Scopus)

  248 Downloads (Pure)

• Downregulation of Keap1 confers features of a fasted metabolic state

  Knatko, E. V., Tatham, M. H., Zhang, Y., Castro, C., Higgins, M., Dayalan Naidu, S., Leonardi, C., de la Vega, L., Honda, T., Griffin, J. L., Hay, R. T. & Dinkova-Kostova, A. T. (Lead / Corresponding author), 23 Oct 2020, In: iScience. 23, 10, 48 p., 101638.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Associated Proteins 100%
  • Metabolic State 100%
  • Kelch-like 100%
  • Metabolic Pathway 100%
  • Synapsin I 100%
  23 Citations (Scopus)

  136 Downloads (Pure)

• Functional 3D architecture in an intrinsically disordered E3 ligase domain facilitates ubiquitin transfer

  Murphy, P., Xu, Y., Rouse, S. L., Jaffray, E. G., Plechanovova, A., Matthews, S. J., Penedo, J. C. & Hay, R. (Lead / Corresponding author), 30 Jul 2020, In: Nature Communications. 11, 13 p., 3807.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitination 100%
  • Ubiquitin 100%
  • E3 Ligase 100%
  • RNF4 100%
  • Intrinsically Disordered 100%
  8 Citations (Scopus)

  103 Downloads (Pure)

• Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

  Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S. (Lead / Corresponding author), 16 Jan 2020, In: Cell Chemical Biology. 27, 1, p. 74-82.e6 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin 100%
  • Activity-based Probes 100%
  • RING E3 Ligase 100%
  • Photocrosslinking 100%
  • Ligase 100%
  26 Citations (Scopus)

  175 Downloads (Pure)

• Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation

  Branigan, E., Penedo, J. C. (Lead / Corresponding author) & Hay, R. (Lead / Corresponding author), 5 Jun 2020, In: Nature Communications. 11, 11 p., 2846.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin 100%
  • RING E3 Ligase 100%
  • Conformation 100%
  • Ligase 100%
  • Closed Conformation 50%
  28 Citations (Scopus)

  96 Downloads (Pure)
• 2019

  An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

  Schmidt, N., Domingues, P., Golebiowski, F., Patzina, C., Tatham, M. H., Hay, R. T. & Hale, B. G. (Lead / Corresponding author), 27 Aug 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17399-17408 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • Small Ubiquitin-like Modifier 100%
  • Endogenous Retrovirus 100%
  • Influenza Virus 100%
  • Antiviral Immunity 100%
  77 Citations (Scopus)

  197 Downloads (Pure)

• Methods to analyze STUbL activity

  Branigan, E., Plechanovová, A. & Hay, R. T. (Lead / Corresponding author), 2019, Methods in Enzymology. Hochstrasser, M. (ed.). Cambridge, MA: Elsevier, Vol. 618. p. 257-280 24 p. (Methods in Enzymology; vol. 618).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

  • E3 Ubiquitin Ligase 100%
  • E3 Ligase Activity 100%
  • Ubiquitin-Conjugating Enzyme 100%
  • Ubiquitin 100%
  • Ubiquitin Protein Ligase E3 100%
  4 Citations (Scopus)

• Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

  Wang, Y., Tatham, M. H., Schmidt-Heck, W., Swann, C., Singh-Dolt, K., Meseguer-Ripolles, J., Lucendo-Villarin, B., Kunath, T., Rudd, T. R., Smith, A. J. H., Hengstler, J. G., Godoy, P., Hay, R. T. & Hay, D. C. (Lead / Corresponding author), 28 Jun 2019, In: iScience. 16, p. 206-217 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Domain 100%
  • Function Domain 100%
  • Multi-omics Analysis 100%
  • Hepatocyte nuclear Factor 100%
  • Pluripotent Stem Cell Differentiation 100%
  14 Citations (Scopus)

  167 Downloads (Pure)

• Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation

  Rabl, J., Bunker, R. D., Schenk, A. D., Cavadini, S., Gill, M. E., Abdulrahman, W., Andrés-Pons, A., Luijsterburg, M. S., Ibrahim, A. F. M., Branigan, E., Aguirre, J. D., Marceau, A. H., Guérillon, C., Bouwmeester, T., Hassiepen, U., Peters, A. H. F. M., Renatus, M., Gelman, L., Rubin, S. M. & Mailand, N. & 3 others, van Attikum, H., Hay, R. T. & Thomä, N. H. (Lead / Corresponding author), 8 Aug 2019, In: Molecular Cell. 75, 3, p. 483-497.e9 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Repair 100%
  • Breast Cancer Susceptibility Gene 1 (BRCA1) 100%
  • Immune Regulation 100%
  • BRCC36 100%
  • BRCA1 100%
  48 Citations (Scopus)

  236 Downloads (Pure)

• Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes

  Pelisch, F. (Lead / Corresponding author), Bel Borja, L., Jaffray, E. & Hay, R., 18 Jul 2019, In: Journal of Cell Science. 132, 14, 13 p., jcs232330.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Anaphase 100%
  • Caenorhabditis Elegans 100%
  • SUMOylation 100%
  • Protein Dynamics 100%
  • Anaphase I 100%
  17 Citations (Scopus)

  202 Downloads (Pure)

• The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

  Winczura, A., Appanah, R., Tatham, M. H., Hay, R. T. & De Piccoli, G. (Lead / Corresponding author), 25 Nov 2019, In: PLoS Genetics. 15, 11, p. 1-26 26 p., e1008427.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • S-phase Checkpoint 100%
  • Catalytic Subunit 100%
  • DNA Polymerase 100%
  • SUMOylation 100%
  • Smc5 100%
  13 Citations (Scopus)

  99 Downloads (Pure)
• 2017

  A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

  Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T. (Lead / Corresponding author), 1 Feb 2017, In: Molecular & Cellular Proteomics. 16, 2, p. 310-326 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aspirin 100%
  • Proteomic Approach 100%
  • Lysine Acetylome 100%
  • Proteomics 100%
  • Lysine 100%
  49 Citations (Scopus)

  275 Downloads (Pure)

• A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis

  Pelisch, F., Tammsalu, T., Wang, B., Jaffray, E. G., Gartner, A. & Hay, R. T. (Lead / Corresponding author), 5 Jan 2017, In: Molecular Cell. 65, 1, p. 66-77 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Network 100%
  • Chromosome Congression 100%
  • Ring Complex 100%
  • Oocyte Meiosis 100%
  • Meiosis 100%
  52 Citations (Scopus)

  498 Downloads (Pure)

• Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

  Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K. (Lead / Corresponding author), 28 Mar 2017, In: Cell Reports. 18, 13, p. 3033-3042 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromosome Replication 100%
  • Helicase 100%
  • Cdc48 100%
  • CDC45 100%
  • Ufd1-Npl4 100%
  36 Citations (Scopus)

  276 Downloads (Pure)
• 2016

  Identification of RNF168 as a PML nuclear body regulator

  Shire, K., Wong, A. I., Tatham, M. H., Anderson, O. F., Ripsman, D., Gulstene, S., Moffat, J., Hay, R. T. & Frappier, L. (Lead / Corresponding author), 1 Feb 2016, In: Journal of Cell Science. 129, 3, p. 580-591 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Promyelocytic Leukemia 100%
  • PML-NBs 100%
  • RNF168 100%
  • Ubiquitin 100%
  • SUMO2 57%
  16 Citations (Scopus)

  222 Downloads (Pure)

• Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

  Maure, J. F., Moser, S. C., Jaffray, E. G., Alpi, A. F. & Hay, R. T. (Lead / Corresponding author), 17 May 2016, In: Scientific Reports. 6, 10 p., 26178.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Erethism 100%
  • DNA Damage 100%
  • Ubiquitin 100%
  • Cell Mutant 100%
  • Mutant Cells 100%
  12 Citations (Scopus)

  217 Downloads (Pure)
• 2015

  Analysis of the SUMO2 proteome during HSV-1 Infection

  Sloan, E., Tatham, M. H., Groslambert, M., Glass, M., Orr, A., Hay, R. T. & Everett, R. D. (Lead / Corresponding author), 22 Jul 2015, In: PLoS Pathogens. 11, 7, 34 p., e1005059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proteome 100%
  • SUMO2 100%
  • Herpes Simplex Virus Type 1 (HSV-1) 100%
  • ICP0 100%
  • Human Alphaherpesvirus 1 100%
  59 Citations (Scopus)

• Global Reprogramming of Host SUMOylation during Influenza Virus Infection

  Domingues, P., Golebiowski, F., Tatham, M. H., Lopes, A. M., Taggart, A., Hay, R. T. & Hale, B. G. (Lead / Corresponding author), 17 Nov 2015, In: Cell Reports. 13, 7, p. 1467-1480 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SUMOylation 100%
  • Influenza-like Illness 100%
  • Global Reprogramming 100%
  • Sumoylation 100%
  • Influenza Virus 100%
  74 Citations (Scopus)

  232 Downloads (Pure)

• Proteome-wide identification of SUMO modification sites by mass spectrometry

  Tammsalu, T., Matic, I., Jaffray, E. G., Ibrahim, A. F. M., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), Sept 2015, In: Nature Protocols. 10, 9, p. 1374-1388 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass Spectrometry 100%
  • Ubiquitin-like 100%
  • Small Ubiquitin-like Modifier 100%
  • Proteome-wide 100%
  • Modification Site 100%
  48 Citations (Scopus)

• Proteotoxic stress reprograms the chromatin landscape of SUMO modification

  Seifert, A., Schofield, P., Barton, G. & Hay, R. (Lead / Corresponding author), 7 Jul 2015, In: Science Signaling. 8, 384, p. rs7 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • SUMO Modification 100%
  • Small Ubiquitin-like Modifier 100%
  • Chromatin Landscape 100%
  • Proteotoxic Stress 100%
  74 Citations (Scopus)

  315 Downloads (Pure)

• Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9

  Rojas-Fernandez, A. (Lead / Corresponding author), Herhaus, L., Macartney, T., Lachaud, C., Hay, R. T. & Sapkota, G. P. (Lead / Corresponding author), 29 Apr 2015, In: Scientific Reports. 5, 6 p., 9811.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Somatic Cells 100%
  • Plasminogen Activator inhibitor-1 (PAI-1) 100%
  • Transcriptional Reporter 100%
  • Rapid Generation 100%
  • Cas9 Protein 100%
  29 Citations (Scopus)

  327 Downloads (Pure)

• Screen for multi-SUMO-binding proteins reveals a multi-SIM-binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin

  Aguilar-Martinez, E., Chen, X., Webber, A., Mould, A. P., Seifert, A., Hay, R. T. & Sharrocks, A. D. (Lead / Corresponding author), 1 Sept 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 35, p. E4854-E4863 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Binding Mechanism 100%
  • Binding Protein 100%
  • Transcriptional Regulator 100%
  • Chromatin 100%
  • Ubiquitin-like 100%
  37 Citations (Scopus)

• Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

  Branigan, E., Plechanovova, A., Jaffray, E. G., Naismith, J. H. (Lead / Corresponding author) & Hay, R. T. (Lead / Corresponding author), Aug 2015, In: Nature Structural & Molecular Biology. 22, 8, p. 597-602 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin 100%
  • K63-linked Ubiquitin Chains 100%
  • Ubc13 50%
  • RNF4 50%
  • RING Domain 50%
  86 Citations (Scopus)

  218 Downloads (Pure)

• Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast

  Køhler, J. B., Tammsalu, T., Jørgensen, M. M., Steen, N., Hay, R. T. & Thon, G. (Lead / Corresponding author), 2015, In: Nature Communications. 6, p. 1-14 14 p., 8827.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • Small Ubiquitin-like Modifier 100%
  • Cdc48 100%
  • Fission Yeast 100%
  • Segregase 100%
  27 Citations (Scopus)

  154 Downloads (Pure)

• Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

  Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), 15 Mar 2015, In: Biochemical Journal. 466, 3, p. 489-498 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin 100%
  • Homopolymer 100%
  • Isopeptide 100%
  • UCHL1 100%
  • C-Terminus 100%
  39 Citations (Scopus)
• 2014

  Dss1 is a 26S proteasome ubiquitin receptor

  Paraskevopoulos, K., Kriegenburg, F., Tatham, M. H., Rösner, H. I., Medina, B., Larsen, I. B., Brandstrup, R., Hardwick, K. G., Hay, R. T., Kragelund, B. B., Hartmann-Petersen, R. (Lead / Corresponding author) & Gordon, C. (Lead / Corresponding author), 6 Nov 2014, In: Molecular Cell. 56, 3, p. 453-461 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 26S Proteasome 100%
  • Ubiquitin Receptor 100%
  • DSS1 100%
  • Proteasome 100%
  • Ubiquitin 100%
  70 Citations (Scopus)

  205 Downloads (Pure)

• Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

  Pelisch, F., Sonneville, R., Pourkarimi, E., Agostinho, A., Blow, J. J., Gartner, A. & Hay, R. T. (Lead / Corresponding author), 5 Dec 2014, In: Nature Communications. 5, 12 p., 5485.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • Caenorhabditis Elegans 100%
  • Cell Cycle Progression 100%
  • Small Ubiquitin-like Modifier 100%
  • Mitotic Chromosome Assembly 100%
  50 Citations (Scopus)

  47 Downloads (Pure)

• E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin

  MacKay, C., Carroll, E., Ibrahim, A. F. M., Garg, A., Inman, G. J., Hay, R. T. & Alpi, A. F., 15 Apr 2014, In: Cancer Research. 74, 8, p. 2246-2257 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cisplatin 100%
  • E3 Ubiquitin Ligase 100%
  • Apoptotic Cell Death 100%
  • Ubiquitin-Conjugating Enzyme 100%
  • Apoptosis 100%
  54 Citations (Scopus)

• Family-wide analysis of poly(ADP-ribose) polymerase activity

  Vyas, S., Matic, I., Uchima, L., Rood, J., Zaja, R., Hay, R. T., Ahel, I. & Chang, P. (Lead / Corresponding author), 21 Jul 2014, In: Nature Communications. 5, 13 p., 4426.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyadenosine 100%
  • Adenosine Diphosphate Ribose 100%
  • ADPr 100%
  • Polymerase Activity 100%
  • Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase 100%
  374 Citations (Scopus)

• PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation

  Hands, K. J., Cuchet-Lourenco, D., Everett, R. D. & Hay, R. T. (Lead / Corresponding author), 15 Jan 2014, In: Journal of Cell Science. 127, 2, p. 365-375 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Multiresolution Analysis 100%
  • Promyelocytic Leukemia 100%
  • PML-NBs 100%
  • Arsenic 100%
  • Body Structure 100%
  40 Citations (Scopus)

  312 Downloads (Pure)

• Proteome-wide identification of SUMO2 modification sites

  Tammsalu, T., Matic, I., Jaffray, E. G., Ibrahim, A. F. M., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), 29 Apr 2014, In: Science Signaling. 7, 323, 10 p., rs2.

  Research output: Contribution to journal › Article › peer-review

  • Lysine 100%
  • Ubiquitin-like 100%
  • SUMO2 100%
  • Small Ubiquitin-like Modifier 100%
  • Proteome-wide 100%
  166 Citations (Scopus)

• siRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells

  Bett, J. S. (Lead / Corresponding author), Ibrahim, A. F. M., Garg, A. K., Rocha, S. & Hay, R. T., 24 May 2014, In: JoVE: Journal of Visualized Experiments. 87, 10 p., e51572.

  Research output: Contribution to journal › Article › peer-review

  • Biological Pathways 100%
  • Ubiquitin-like 100%
  • Ubiquitin 100%
  • Cultured Human Cells 100%
  • RNAi Screen 100%
  2 Citations (Scopus)

• Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

  Xu, Y., Plechanovová, A., Simpson, P., Marchant, J., Leidecker, O., Kraatz, S., Hay, R. T. (Lead / Corresponding author) & Matthews, S. J. (Lead / Corresponding author), 27 Jun 2014, In: Nature Communications. 5, 12 p., 4217.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-like 100%
  • Small Ubiquitin-like Modifier 100%
  • Structural Insights 100%
  • Ubiquitin Ligase 100%
  • RNF4 100%
  33 Citations (Scopus)

  311 Downloads (Pure)

• SUMO chain-induced dimerization activates RNF4

  Rojas-Fernandez, A., Plechanovová, A., Hattersley, N., Jaffray, E., Tatham, M. H. & Hay, R. T. (Lead / Corresponding author), 20 Mar 2014, In: Molecular Cell. 53, 6, p. 880-92 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dimerization 100%
  • Ubiquitin-Conjugating Enzyme 100%
  • RNF4 100%
  • SUMO Chains 100%
  • Ligase 66%
  67 Citations (Scopus)

  250 Downloads (Pure)
• 2013

  Decoding the SUMO signal

  Hay, R. T., Apr 2013, In: Biochemical Society Transactions. 41, 2, p. 463-473 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin-like 100%
  • Small Ubiquitin-like Modifier 100%
  • Ubiquitin 100%
  • SUMO-interacting Motif 22%
  • Biological Processes 11%
  103 Citations (Scopus)

• The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

  Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T., 15 Apr 2013, In: Biochemical Journal. 451, 2, p. 185-194 10 p., BJ20130026.

  Research output: Contribution to journal › Article › peer-review

  • Body Components 100%
  • Novel Regulator 100%
  • Hypoxia-inducible factor-1α (HIF-1α) 100%
  • Ubiquitin-specific Protease 100%
  • MRNA Stability 100%
  47 Citations (Scopus)

• Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

  Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T., 2013, In: Biochemical Journal. 453, 1, p. 137-145 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Amino Group 100%
  • Ubiquitin 100%
  • Ubiquitylation 100%
  • Protein N-termini 100%
  • UBE2W 100%
  85 Citations (Scopus)
• 2012

  Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites

  Matic, I. (Lead / Corresponding author), Ahel, I. & Hay, R. T., Aug 2012, In: Nature Methods. 9, 8, p. 771-772 2 p.

  Research output: Contribution to journal › Letter › peer-review
  64 Citations (Scopus)

• Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

  Plechanovová, A., Jaffray, E. G., Tatham, M. H., Naismith, J. H. & Hay, R. T. (Lead / Corresponding author), 2012, In: Nature. 489, 7414, p. 115-120 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Ubiquitin 100%
  • RING E3 Ligase 100%
  • Ligase 100%
  • Protomers 28%
  • Active Sites 28%
  419 Citations (Scopus)

• SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

  Yin, Y., Seifert, A., Chua, J. S., Maure, J.-F., Golebiowski, F. & Hay, R. T. (Lead / Corresponding author), 1 Jun 2012, In: Genes & Development. 26, 11, p. 1196-1208 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Cells 100%
  • DNA Damage 100%
  • Ubiquitin-like 100%
  • E3 Ubiquitin Ligase 100%
  • Small Ubiquitin-like Modifier 100%
  198 Citations (Scopus)