DIRECT: Diabetes Research on Patient Stratification (joint with 25 other partners)

Project Details

StatusActive
Effective start/end date1/02/12 → 30/06/23

Funding

  • (115317): £463,529.00
  • COMMISSION OF THE EUROPEAN COMMUNITIES (115317-DIRECT): £5,923,228.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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  • Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

    IMI DIRECT Consortium, Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., Brasas, V., Webel, H., Benros, M. E., Pedersen, A. G., Chmura, P. J., Jacobsen, U. P., Mari, A., Koivula, R., Mahajan, A., & 33 othersVinuela, A., Tajes, J. F., Sharma, S., Haid, M., Hong, M-G., Musholt, P. B., De Masi, F., Vogt, J., Pedersen, H. K., Gudmundsdottir, V., Jones, A., Kennedy, G., Bell, J., Thomas, E. L., Frost, G., Thomsen, H., Hansen, E., Hansen, T. H., Vestergaard, H., Muilwijk, M., Blom, M. T., 't Hart, L. M., Pattou, F., Raverdy, V., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Mourby, M., Forgie, I., Pearson, E., Rasmussen, S. & Brunak, S., 2 Jan 2023, (E-pub ahead of print) In: Nature Biotechnology. 17 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    2 Downloads (Pure)

  • Pharmacogenomics of GLP-1 Receptor Agonists: a genome-wide analysis of observational data and large randomised controlled trials

    Dawed, A. Y., Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., Hong, M-G., Sharma, S., Robertson, N. R., Mahajan, A., Wang, X., Walker, M., Gough, S., 't Hart, L. M., Zhou, K., Forgie, I., Ruetten, H., Pavo, I., Bhatnagar, P., Jones, A. G., & 1 othersPearson, E. R., 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    1 Citation (Scopus)
    30 Downloads (Pure)

  • Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

    IMI DIRECT Consortium, Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M-G., Musholt, P. B., Kurbasic, A., De Masi, F., Tsirigos, K., Pedersen, H. K., & 41 othersGudmundsdottir, V., Thomas, C. E., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G. N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E. T., Franks, P. W., Schwenk, J. M., Adamski, J., Pearson, E., McCarthy, M. I. & Brunak, S., 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 32 p., 100477.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    18 Citations (Scopus)
    21 Downloads (Pure)
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