DIRECT: Diabetes Research on Patient Stratification (joint with 25 other partners)

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  • 2024

    The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

    Eriksen, R., White, M. C., Dawed, A. Y., Perez, I. G., Posma, J. M., Haid, M., Sharma, S., Prehn, C., Thomas, E. L., Koivula, R. W., Bizzotto, R., Mari, A., Giordano, G. N., Pavo, I., Schwenk, J. M., De Masi, F. D., Tsirigos, K. D., Brunak, S., Viñuela, A. & Mahajan, A. & 26 others, McDonald, T. J., Kokkola, T., Rutters, F., Beulens, J., Muilwijk, M., Blom, M., Elders, P., Hansen, T. H., Fernandez-Tajes, J., Jones, A., Jennison, C., Walker, M., McCarthy, M. I., Pedersen, O., Ruetten, H., Forgie, I., Holst, J. J., Thomsen, H. S., Ridderstråle, M., Bell, J. D., Adamski, J., Franks, P. W., Hansen, T., Holmes, E., Frost, G. (Lead / Corresponding author) & Pearson, E. R. (Lead / Corresponding author), 1 Sept 2024, In: Journal of Clinical Endocrinology & Metabolism. 109, 9, p. e1697-e1707 11 p., dgae119.

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  • 2023

    Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

    IMI DIRECT Consortium, Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., Rodríguez, C. L., Brasas, V., Webel, H., Benros, M. E., Pedersen, A. G., Chmura, P. J., Jacobsen, U. P., Mari, A. & Koivula, R. & 34 others, Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Hong, M.-G., Musholt, P. B., De Masi, F., Vogt, J., Pedersen, H. K., Gudmundsdottir, V., Jones, A., Kennedy, G., Bell, J., Thomas, E. L., Frost, G., Thomsen, H., Hansen, E., Hansen, T. H., Vestergaard, H., Muilwijk, M., Blom, M. T., 't Hart, L. M., Pattou, F., Raverdy, V., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Mourby, M., Forgie, I., Pearson, E., Rasmussen, S. (Lead / Corresponding author) & Brunak, S. (Lead / Corresponding author), Mar 2023, In: Nature Biotechnology. 41, p. 399-408 10 p.

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  • Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

    Brown, A. A., Fernandez-Tajes, J. J., Hong, M.-G., Brorsson, C. A., Koivula, R. W., Davtian, D., Dupuis, T., Sartori, A., Michalettou, T.-D., Forgie, I. M., Adam, J., Allin, K. H., Caiazzo, R., Cederberg, H., De Masi, F., Elders, P. J. M., Giordano, G. N., Haid, M., Hansen, T. & Hansen, T. H. & 39 others, Hattersley, A. T., Heggie, A. J., Howald, C., Jones, A. G., Kokkola, T., Laakso, M., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Mourby, M., Musholt, P. B., Nilsson, B., Pattou, F., Penet, D., Raverdy, V., Ridderstråle, M., Romano, L., Rutters, F., Sharma, S., Teare, H., Hart, L., Tsirigos, K. D., Vangipurapu, J., Vestergaard, H., Brunak, S., Franks, P. W., Frost, G., Grallert, H., Jablonka, B., McCarthy, M., Pavo, I., Pedersen, O., Ruetten, H., Walker, M., The DIRECT consortium, Pearson, E. R., Dermitzakis, E. T. (Lead / Corresponding author) & Viñuela, A. (Lead / Corresponding author), 21 Aug 2023, In: Nature Communications. 14, 17 p., 5062.

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  • Pharmacogenomics of GLP-1 Receptor Agonists: a genome-wide analysis of observational data and large randomised controlled trials

    Dawed, A. Y. (Lead / Corresponding author), Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., Hong, M.-G., Sharma, S., Robertson, N. R., Mahajan, A., Wang, X., Walker, M., Gough, S., 't Hart, L. M., Zhou, K., Forgie, I., Ruetten, H., Pavo, I., Bhatnagar, P. & Jones, A. G. & 2 others, Pearson, E. R. (Lead / Corresponding author) & DIlinRECT consortium, 1 Jan 2023, In: The Lancet Diabetes and Endocrinology. 11, 1, p. 33-41 9 p.

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  • 2022

    Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

    IMI DIRECT Consortium, Wesolowska-Andersen, A., Brorsson, C. A., Bizzotto, R., Mari, A., Tura, A., Koivula, R., Mahajan, A., Vinuela, A., Tajes, J. F., Sharma, S., Haid, M., Prehn, C., Artati, A., Hong, M.-G., Musholt, P. B., Kurbasic, A., De Masi, F., Tsirigos, K. & Pedersen, H. K. & 41 others, Gudmundsdottir, V., Thomas, C. E., Banasik, K., Jennison, C., Jones, A., Kennedy, G., Bell, J., Thomas, L., Frost, G., Thomsen, H., Allin, K., Hansen, T. H., Vestergaard, H., Hansen, T., Rutters, F., Elders, P., t'Hart, L., Bonnefond, A., Canouil, M., Brage, S., Kokkola, T., Heggie, A., McEvoy, D., Hattersley, A., McDonald, T., Teare, H., Ridderstrale, M., Walker, M., Forgie, I., Giordano, G. N., Froguel, P., Pavo, I., Ruetten, H., Pedersen, O., Dermitzakis, E. T., Franks, P. W., Schwenk, J. M., Adamski, J., Pearson, E. (Lead / Corresponding author), McCarthy, M. I. (Lead / Corresponding author) & Brunak, S. (Lead / Corresponding author), 18 Jan 2022, In: Cell Reports Medicine. 3, 1, 32 p., 100477.

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  • 2021

    Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: an IMI-DIRECT study

    Obura, M., Beulens, J. W. J., Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Dekker, J. M., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A. & McCarthy, M. I. & 8 others, Walker, M., McDonald, T. J., Perry, M. H., Pearson, E. R., Franks, P. W., 't Hart, L. M., Rutters, F. (Lead / Corresponding author) & IMI DIRECT Consortium, 28 Jan 2021, In: Diabetic Medicine. 38, 2, 10 p., e14428.

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  • Elevated circulating follistatin associates with an increased risk of type 2 diabetes

    Wu, C., Borné, Y., Gao, R., López Rodriguez, M., Roell, W. C., Wilson, J. M., Regmi, A., Luan, C., Aly, D. M., Peter, A., Machann, J., Staiger, H., Fritsche, A., Birkenfeld, A. L., Tao, R., Wagner, R., Canouil, M., Hong, M. G., Schwenk, J. M. & Ahlqvist, E. & 22 others, Kaikkonen, M. U., Nilsson, P., Shore, A. C., Khan, F., Natali, A., Melander, O., Orho-Melander, M., Nilsson, J., Häring, H. U., Renström, E., Wollheim, C. B., Engström, G., Weng, J., Pearson, E. R., Franks, P. W., White, M. F., Duffin, K. L., Vaag, A. A., Laakso, M., Stefan, N., Groop, L. & De Marinis, Y. (Lead / Corresponding author), 10 Nov 2021, In: Nature Communications. 12, 10 p., 6486.

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  • Genome-Wide Association Analysis of Pancreatic Beta Cell Glucose Sensitivity

    Deshmukh, H. A., Madsen, A. L., Viñuela, A., Have, C. T., Grarup, N., Tura, A., Mahajan, A., Heggie, A. J., Koivula, R. W., De Masi, F., Tsirigos, K. K., Linneberg, A., Drivsholm, T., Pedersen, O., Sørensen, T. I. A., Astrup, A., Gjesing, A. A. P., Pavo, I., Wood, A. R. & Ruetten, H. & 14 others, Jones, A. G., Koopman, A. D. M., Cederberg, H., Rutters, F., Ridderstrale, M., Laakso, M., McCarthy, M. I., Frayling, T. M., Ferrannini, E., Franks, P. W., Pearson, E. R., Mari, A. (Lead / Corresponding author), Hansen, T. (Lead / Corresponding author) & Walker, M. (Lead / Corresponding author), Jan 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 1, p. 80-90 11 p.

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  • 2020

    Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

    Obura, M., Beulens, J. W. J. (Lead / Corresponding author), Slieker, R., Koopman, A. D. M., Hoekstra, T., Nijpels, G., Elders, P., Koivula, R. W., Kurbasic, A., Laakso, M., Hansen, T. H., Ridderstråle, M., Hansen, T., Pavo, I., Forgie, I., Jablonka, B., Ruetten, H., Mari, A., McCarthy, M. I. & Walker, M. & 19 others, Heggie, A., McDonald, T. J., Perry, M. H., De Masi, F., Brunak, S., Mahajan, A., Giordano, G. N., Kokkola, T., Dermitzakis, E., Viñuela, A., Pedersen, O., Schwenk, J. M., Adamski, J., Teare, H. J. A., Pearson, E. R., Franks, P. W., 't Hart, L. M., Rutters, F. & IMI DIRECT Consortium, 30 Nov 2020, In: PLoS ONE. 15, 11, 11 p., e0242360.

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  • Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

    Gudmundsdottir, V., Pedersen, H. K., Mazzoni, G., Allin, K. H., Artati, A., Beulens, J. W., Banasik, K., Brorsson, C., Cederberg, H., Chabanova, E., De Masi, F., Elders, P. J., Forgie, I., Giordano, G. N., Grallert, H., Gupta, R., Haid, M., Hansen, T., Hansen, T. H. & Hattersley, A. T. & 36 others, Heggie, A., Hong, M. G., Jones, A. G., Koivula, R., Kokkola, T., Laakso, M., Løngreen, P., Mahajan, A., Mari, A., McDonald, T. J., McEvoy, D., Musholt, P. B., Pavo, I., Prehn, C., Ruetten, H., Ridderstråle, M., Rutters, F., Sharma, S., Slieker, R. C., Syed, A., Tajes, J. F., Thomas, C. E., Thomsen, H. S., Vangipurapu, J., Vestergaard, H., Viñuela, A., Wesolowska-Andersen, A., Walker, M., Adamski, J., Schwenk, J. M., McCarthy, M. I., Pearson, E., Dermitzakis, E., Franks, P. W., Pedersen, O. & Brunak, S. (Lead / Corresponding author), 1 Dec 2020, In: Genome Medicine. 12, 17 p., 109.

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  • 2019

    A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

    Grubb, A. L., McDonald, T. J., Rutters, F., Donnelly, L., Hattersley, A. T., Oram, R. A., Palmer, C., van der Heijden, A. A., Carr, F., Elders, P. J. M., Weedon, M., Slieker, R. C., 't Hart, L. M., Pearson, E., Shields, B. M. & Jones, A. G. (Lead / Corresponding author), 1 Feb 2019, In: Diabetes Care. 42, 2, p. 208-214 7 p.

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  • Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

    Ji, Y., Yiorkas, A. M., Frau, F., Mook-Kanamori, D., Staiger, H., Thomas, E. L., Atabaki-Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., Beaumont, R. N., Wood, A. R., Tuke, M. A., Ruth, K. S., Mahajan, A., Murray, A., Freathy, R. M., Weedon, M. N., Hattersley, A. T. & Hayward, C. & 11 others, Machann, J., Häring, H.-U., Franks, P., de Mutsert, R., Pearson, E., Stefan, N., Frayling, T. M., Allebrandt, K. V., Bell, J. D., Blakemore, A. I. & Yaghootkar, H. (Lead / Corresponding author), 1 Jan 2019, In: Diabetes. 68, 1, p. 207-219 13 p.

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  • Motivations for data sharing-views of research participants from four European countries: A DIRECT study

    Shah, N. (Lead / Corresponding author), Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., 30 Jan 2019, In: European Journal of Human Genetics. 27, 5, p. 721-729 9 p.

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  • Sharing data for future research-engaging participants' views about data governance beyond the original project: a DIRECT Study

    Shah, N. (Lead / Corresponding author), Coathup, V., Teare, H., Forgie, I., Giordano, G. N., Hansen, T. H., Groeneveld, L., Hudson, M., Pearson, E., Ruetten, H. & Kaye, J., May 2019, In: Genetics in Medicine. 21, p. 1131-1138 8 p.

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  • 2018

    Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

    Molnos, S., Wahl, S., Haid, M., Eekhoff, E. M. W., Pool, R., Floegel, A., Deelen, J., Much, D., Prehn, C., Breier, M., Draisma, H. H. M., van Leeuwen, N., Simonis-Bik, A. M. C., Jonsson, A., Willemsen, G., Bernigau, W., Wang-Sattler, R., Suhre, K., Peters, A. & Thorand, B. & 24 others, Herder, C., Rathmann, W., Roden, M., Gieger, C., Kramer, M. H. H., van Heemst, D., Pedersen, H. K., Gudmundsdottir, V., Schulze, M. B., Pischon, T., de Geus, E. J. C., Boeing, H., Boomsma, D. I., Ziegler, A. G., Slagboom, P. E., Hummel, S., Beekman, M., Grallert, H., Brunak, S., McCarthy, M. I., Gupta, R., Pearson, E. R., Adamski, J. & 't Hart, L. M. (Lead / Corresponding author), Jan 2018, In: Diabetologia. 61, 1, p. 117-129 13 p.

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  • The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

    Teare, H. J. A. (Lead / Corresponding author), de Masi, F., Banasik, K., Barnett, A., Herrgard, S., Jablonka, B., Postma, J. W. M., McDonald, T. J., Forgie, I., Chmura, P. J., Rydzka, E. K., Gupta, R., Brunak, S., Pearson, E. & Kaye, J., 4 Sept 2018, In: Life Sciences, Society and Policy. 14, 1, p. 1-17 17 p., 20.

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  • The search for predictive metabolic biomarkers for incident T2DM

    Pearson, E. & Adamski, J. (Lead / Corresponding author), 18 Jun 2018, In: Nature Reviews Endocrinology. 14, 8, p. 444-446 3 p.

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  • 2017

    Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes

    Dawed, A. Y. (Lead / Corresponding author), Ali, A., Zhou, K., Pearson, E. R. & Franks, P. W., Nov 2017, In: Diabetologia. 60, 11, p. 2231-2239 8 p.

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  • Rates of glycaemic deterioration in a real-world population with type 2 diabetes

    Donnelly, L. A., Zhou, K., Doney, A. S. F., Jennison, C., Franks, P. W. & Pearson, E. R. (Lead / Corresponding author), 19 Dec 2017, In: Diabetologia. 61, p. 607-615 9 p.

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  • The sustained influence of metformin therapy on circulating GLP-1 levels in individuals with and without type 2 diabetes

    Preiss, D. (Lead / Corresponding author), Dawed, A., Welsh, P., Heggie, A., Jones, A. G., Dekker, J., Koivula, R., Hansen, T. H., The DIRECT consortium, Stewart, C., Holman, R. R., Franks, P. W., Walker, M., Pearson, E. R. & Sattar, N., Mar 2017, In: Diabetes, Obesity & Metabolism. 19, 3, p. 356-363 8 p.

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  • Variants in pharmacokinetic transporters and glycemic response to metformin: A metgen meta-analysis

    Dujic, T., Zhou, K., Yee, S. W., van Leeuwen, N., de Keyser, C. E., Javorský, M., Goswami, S., Zaharenko, L., Christiansen, M. M. H., Out, M., Tavendale, R., Kubo, M., Hedderson, M. M., van der Heijden, A. A., Klimčáková, L., Pirags, V., Kooy, A., Brøsen, K., Klovins, J. & Semiz, S. & 6 others, Tkáč, I., Stricker, B. H., Palmer, C. N. A., 't Hart, L. M., Giacomini, K. M. & Pearson, E. R. (Lead / Corresponding author), Jun 2017, In: Clinical Pharmacology & Therapeutics. 101, 6, p. 763-772 10 p.

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