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Discovery and Development of Drug Candidates for Neglected Diseases (joint with industrial partner)
Brenk, Ruth
(Investigator)
Fairlamb, Alan
(Investigator)
Ferguson, Michael
(Investigator)
Field, Mark
(Investigator)
Gilbert, Ian
(Investigator)
Gray, David
(Investigator)
Hopkins, Andrew
(Investigator)
Horn, David
(Investigator)
Read, Kevin
(Investigator)
Wyatt, Paul
(Investigator)
van Aalten, Daan
(Investigator)
Biological Chemistry and Drug Discovery
Drug Discovery Unit
Gene Regulation and Expression
Overview
Research Outputs
(26)
Project Details
Status
Finished
Effective start/end date
1/02/11
→
1/07/17
Funding
Wellcome Trust
(092340)
Wellcome Trust
(Diana Tay):
£336,000.00
Wellcome Trust
(092340 via milestone):
£6,535,971.00
View all
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Research Output
Research Output per year
2013
2020
25
Article
1
Review article
Research Output per year
Research Output per year
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase
Torrie, L. S.
, Robinson, D. A.,
Thomas, M. G.
, Hobrath, J. V., Shepherd, S. M., Post, J. M., Ko, E. J., Ferreira, R. A.,
Mackenzie, C. J.
, Wrobel, K.,
Edwards, D. P.
,
Gilbert, I. H.
,
Gray, D. W.
,
Fairlamb, A. H.
&
De Rycker, M.
,
8 May 2020
,
In:
ACS Infectious Diseases.
6
,
5
,
p. 1044-1057
14 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Methionine-tRNA Ligase
Allosteric Site
Binding Sites
Trypanosoma cruzi
Enzymes
21
Downloads (Pure)
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity
Thomas, M.
,
De Rycker, M.
,
Wall, R. J.
, Spinks, D.,
Epemolu, O.
,
Manthri, S.
,
Norval, S.
,
Osuna-Cabello, M.
, Patterson, S.,
Riley, J.
,
Simeons, F. R. C.
,
Stojanovski, L.
,
Thomas, J.
,
Thompson, S.
,
Naylor, C.
, Fiandor, J. M.,
Wyatt, P. G.
, Marco, M.,
Wyllie, S.
,
Read, K. D.
& 2 others
,
Miles, T. J. &
Gilbert, I. H.
,
10 Sep 2020
,
In:
Journal of Medicinal Chemistry.
63
,
17
,
p. 9523-9539
17 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Naphthyridines
Visceral Leishmaniasis
Neglected Diseases
Divalent Cations
Parasitic Diseases
25
Downloads (Pure)
Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis
Thomas, M. G.
,
De Rycker, M.
, Ajakane, M., Crouch, S. D.,
Campbell, L.
, Daugan, A., Fra, G., Guerrero, C.,
Mackenzie, C. J.
,
MacLean, L.
,
Manthri, S.
, Martin, F.,
Norval, S.
,
Osuna-Cabello, M.
,
Riley, J.
,
Shishikura, Y.
, Miguel-Siles, J.,
Simeons, F. R. C.
,
Stojanovski, L.
,
Thomas, J.
& 7 others
,
Thompson, S.
, Velasco, R. F., Fiandor, J. M.,
Wyatt, P. G.
,
Read, K. D.
,
Gilbert, I. H.
& Miles, T. J.
,
21 Oct 2020
,
In:
RSC Medicinal Chemistry.
11
,
10
,
p. 1168-1177
10 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
pyrazolo(3,4-d)pyrimidine
Visceral Leishmaniasis
Developing Countries
23
Downloads (Pure)