Project Details
| Status | Finished |
|---|---|
| Effective start/end date | 8/04/13 → 7/07/15 |
Funding
- Biotechnology and Biological Sciences Research Council (BB/G023123/2): £307,127.00
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Diehl, C. J. & Ciulli, A. (Lead / Corresponding author), 19 Aug 2022, In: Chemical Society Reviews. 51, 19, p. 8216-8257 42 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile157 Citations (Scopus)425 Downloads (Pure) -
Targeting epigenetic reader domains by chemical biology
Cipriano, A., Sbardella, G. (Lead / Corresponding author) & Ciulli, A. (Lead / Corresponding author), Aug 2020, In: Current Opinion in Chemical Biology. 57, p. 82-94 13 p.Research output: Contribution to journal › Review article › peer-review
23 Citations (Scopus) -
Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
Soares, P., Gadd, M., Frost, J., Galdeano, C., Ellis, L., Epemolu, R., Rocha, S., Read, K. & Ciulli, A. (Lead / Corresponding author), 25 Jan 2018, In: Journal of Medicinal Chemistry. 61, p. 599-618 19 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile138 Citations (Scopus)446 Downloads (Pure)