Keyphrases
1,4-Benzodiazepine
6%
1-Methyl
6%
4H-1
6%
Acetic Acid
6%
Active Chemicals
8%
Active-site Cysteine
6%
Adaptor
6%
Allosteric Pocket
6%
Allosteric Targeting
12%
Alpha Subunit
14%
Ankyrin Repeat
12%
BAZ2A
6%
BAZ2B
18%
Benzodiazepines
15%
Benzyl
12%
BET Bromodomain
14%
Binder
6%
Binding Affinity
13%
Binding Energetics
6%
Binding Hotspots
12%
Binding Mode
8%
Biochemical Characterization
6%
Biological Pathways
6%
Biological Processes
6%
Biological Reactions
6%
Biophysical Assays
17%
Biophysical Characterization
6%
Biophysical Methods
10%
Biophysical Studies
12%
Biophysical Techniques
7%
Bona Fide
6%
BRD2
6%
BRD3
6%
Bromo
38%
Bromodomain
78%
Bromodomain Inhibitors
28%
Bromodomain Proteins
14%
Bromodomain-containing Protein 4 (BRD4)
17%
Building Structure
6%
Bump
40%
Carboxamide
12%
Cautionary Tales
6%
Chemical Biology
35%
Chemical Drugs
19%
Chemical Genetics
26%
Chemical Potential
6%
Chemical Probes
100%
Chemical Tools
14%
Chromatin
5%
Chromatin Remodelers
12%
Co-crystal Structure
9%
Component Size
6%
Conformational Flexibility
12%
Controlled Selectivity
12%
CRL Complex
14%
CUL5
8%
Cullin
7%
Cullin 5
25%
Cullin-RING
12%
Cullin-RING E3 Ligase
38%
Cyclic Peptide
17%
Degrader
12%
Deubiquitinating Enzyme
25%
Differential Scanning Fluorimetry
7%
DNA Repair Pathways
6%
Domain Switching
6%
Drug Discovery
29%
Druggability
12%
E3 Ligase
22%
E3 Ubiquitin Ligase
53%
Efficient Development
6%
Elongin
5%
Elongin C
5%
Epigenetic Mechanisms
7%
Epigenetic Reader Domain
14%
Epigenetics
20%
Extra-terminal Domain
12%
Fanconi Anemia
19%
Fluorescence Method
6%
Fluorescence Polarization
6%
Fragment Binding
8%
Fragment Library
12%
Fragment Screening
31%
Full-size
19%
Functional Domain
12%
Genetic Approach
25%
Gram-scale
12%
Group-based
12%
Growth Hormone Receptor
8%
High Affinity
17%
High-throughput
10%
Histone
15%
Histone H3 Tail
12%
Histone Post-translational Modifications
7%
Histone Tails
19%
Hit Compound
6%
Human Disease
8%
Hydroxylation
12%
Hypoxia-inducible Factor
18%
Hypoxia-inducible factor-1α (HIF-1α)
21%
Hypoxic Signaling
12%
Impurities
12%
Indol
6%
Induced Degradation
12%
Isothermal Titration Calorimetry
15%
Laboratory Synthesis
12%
Large Families
9%
Ligand Binding
8%
Ligand Screening
10%
Ligand-based NMR
8%
Linear Assembly
6%
Macrocyclic Peptides
12%
Macromolecules
6%
Medicinal Chemistry
23%
Methoxy
6%
Methyl Ester
6%
Methylene
6%
Molecular Recognition
12%
Multimeric Complexes
12%
Multisubunit Complexes
11%
New Frontiers
12%
New Synthetic Route
12%
NMR Spectroscopy
17%
NoRC
12%
Novel Therapeutics
6%
Nuclear Magnetic Resonance
12%
Observed Effects
6%
On-target Effects
15%
Oncogene
6%
Pharmaceutical Industry
6%
Pharmacological Inhibitors
12%
PHD Finger
12%
Plant Homeodomain Finger
12%
Post-translational Modification
11%
Probe Compound
6%
Proteasomal Degradation
8%
Protein Complex
14%
Protein Function
6%
Protein Probe
12%
Protein Surface
15%
Protein X-ray Crystallography
6%
Protein-protein Interaction
52%
Proteolysis Targeting chimera (PROTAC)
18%
Pyrrolidine-2
12%
Rational Structure
6%
Reader Domain
6%
Reader Modules
6%
Relevant Protein
12%
Secondary Structure
9%
Selective Intervention
12%
Seven Steps
6%
Side Chain
6%
Small Molecule Binding
7%
Small Molecule Inhibitors
12%
Small Molecule Libraries
12%
Small Molecule Ligands
29%
Small Molecule Modulators
6%
Small Molecule Peptide
6%
Small Molecule Targeting
12%
Small Molecule Therapeutics
6%
Small Molecules
53%
SOCS Box
12%
SOCS1
8%
Solution NMR
12%
State of the Field
6%
Structural Plasticity
6%
Structural Rearrangement
12%
Structural Techniques
6%
Structure Optimization
12%
Structure-activity Relationship
20%
Structure-based Design
23%
Structure-based Drug Design
6%
Structure-based Lead Discovery
12%
Structure-guided
12%
Substrate Peptide
6%
Substrate Receptors
23%
Substrate Specificity
6%
Suppressor of Cytokine Signaling 2
25%
Surface Plasmon Resonance
6%
Target Selectivity
12%
Target Validation
21%
Terminal Protein
11%
Therapeutic Targeting
7%
Thermal Shift
6%
TIP5
15%
Trimerization
6%
Tumor Suppressor
6%
UBE2T
19%
Ubiquitin Conjugation
6%
Ubiquitin System
12%
Ubiquitin-proteasome System
17%
Ubiquitination
8%
VH298
17%
Von Hippel-Lindau
38%
Von Hippel-Lindau Disease
6%
Weak Affinity
6%
Zinc
12%
Zinc Binding
6%
Zinc Finger
5%
Zinc Ion
6%
Biochemistry, Genetics and Molecular Biology
Acetylation
6%
Allele
12%
Alpha Chain
14%
Ankyrin
12%
Ankyrin Repeat
12%
Binding Affinity
11%
BRD2
6%
BRD4
15%
Bromodomain
83%
Chemical Genetics
26%
Chromatin Remodeling
12%
Conformation
6%
Crystal Structure
23%
Cullin
45%
Cysteine
6%
Cytokine
25%
DNA Repair
6%
Dynamics
8%
Elongin
9%
Enzyme
8%
Epigenetics
26%
Epigenetics
17%
Epigenomics
17%
Genetic Approach
25%
Growth Hormone Receptor
5%
Histone
39%
Histone H3
15%
Homeodomain
12%
Hydroxylation
12%
Hypoxia Inducible Factor 1
19%
Hypoxia-Inducible Factors
40%
Ion Mobility Mass Spectrometry
5%
Isothermal Titration Calorimetry
10%
Ligand Binding
5%
Lysine
5%
Molecular Library
8%
Molecular Recognition
12%
Molecular Weight
6%
Multiprotein Complex
12%
Multisubunit-Complex
7%
N-Terminus
7%
Nuclear Magnetic Resonance Spectroscopy
18%
PHD Finger
12%
Posttranslational Modification
19%
Promoter Region
6%
Proteasome
14%
Protein Interaction
8%
Protein Secondary Structure
10%
Protein Structure
6%
Protein-Protein Interaction
46%
Proteolysis
23%
Proteome
6%
Signaling Protein
5%
Small Molecule
99%
Solution and Solubility
31%
Structure Activity Relation
17%
Tumor Suppressor Protein
7%
Ubiquitin
28%
Ubiquitin Ligase
27%
Ubiquitin-Conjugating Enzyme
93%
Ubiquitination
13%
X Ray
6%
X-Ray Crystallography
5%