DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

Project Details

StatusFinished
Effective start/end date1/05/1330/04/18

Funding

  • COMMISSION OF THE EUROPEAN COMMUNITIES (311460 (ERC-2012-StG_20111109)): £1,284,109.00

Research Output

Bifunctional chemical probes inducing protein-protein interactions

Maniaci, C. & Ciulli, A., Oct 2019, In : Current Opinion in Chemical Biology. 52, p. 145-156 12 p.

Research output: Contribution to journalReview article

  • 4 Citations (Scopus)

    Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

    Girardini, M., Maniaci, C., Hughes, S., Testa, A. & Ciulli, A., 15 Jun 2019, In : Bioorganic & Medicinal Chemistry. 27, 12, p. 2466-2479 14 p.

    Research output: Contribution to journalArticle

    Open Access
  • 7 Citations (Scopus)

    Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

    Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A. & Alessi, D., 20 Sep 2019, In : ACS Chemical Biology. 14, 9, p. 2024-2034 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    74 Downloads (Pure)