Keyphrases
Proteolysis Targeting chimera (PROTAC)
100%
Von Hippel-Lindau
62%
E3 Ubiquitin Ligase
59%
Degrader
49%
E3 Ligase
49%
Ternary Complex
41%
Structure-based Design
29%
Bromodomain-containing Protein 4 (BRD4)
28%
Small Molecules
27%
Protein-protein Interaction
26%
Chemical Probes
26%
Cullin-RING E3 Ligase
26%
Bromodomain
23%
Targeted Protein Degradation
20%
Suppressor of Cytokine Signaling 2
20%
Protein Degradation
15%
Fragment Screening
15%
Hypoxia-inducible factor-1α (HIF-1α)
14%
Ubiquitination
13%
Molecular Recognition
13%
Cooperativity
13%
Bromo
13%
Protein Degraders
11%
BRD2
11%
Linker
11%
Targeted Degradation
11%
Hypoxia-inducible Factor
11%
Cullin 5
11%
Phosphotyrosine
11%
Molecular Glue
10%
Substrate Receptors
10%
Small Molecule Inhibitors
10%
Ubiquitin-proteasome System
10%
Binding Affinity
10%
Deubiquitinating Enzyme
10%
Hydroxyproline
10%
Knockdown
9%
VH298
9%
Structure-activity Relationship
9%
UBE2T
9%
Dimerizer
9%
Biophysical Studies
9%
X-ray Crystallography
9%
Elongin
8%
Substrate Recognition
8%
SGK3
8%
PROTAC Degraders
7%
Bifunctional
7%
Small Molecule Ligands
7%
Drug Discovery
7%
Co-crystal Structure
7%
Adaptor
7%
Full-size
7%
Von Hippel-Lindau Disease
7%
Protein Complex
7%
Fanconi Anemia
7%
Protein of Interest
7%
Bromodomain Inhibitors
7%
Ligase
7%
Bump
7%
Cullin2
7%
Selective Degradation
7%
Isothermal Titration Calorimetry
6%
Binder
6%
Chemical Genetics
6%
Proteasomal Degradation
6%
Nuclear Magnetic Resonance
6%
Multisubunit
6%
Targeted Protein Degraders
6%
Target Molecule
6%
Rapid Degradation
6%
Extra-terminal Domain
6%
Plant Homeodomain Finger
6%
Histone H3 Tail
6%
Recent Advances
6%
Structural Features
6%
Zinc Finger
6%
E3 Ligase Ligands
6%
Small Molecule Targeting
6%
Epigenetics
6%
Multisubunit Complexes
5%
Alpha Subunit
5%
HaloPROTAC
5%
Bromodomain Proteins
5%
Hydroxylation
5%
Medicinal Chemistry
5%
Induced Degradation
5%
Biophysical Methods
5%
Cereblon
5%
Hijacking
5%
Small Molecule Degrader
5%
CRL Complex
5%
Allele-specific
5%
Ternary Complex Formation
5%
Drug Target
5%
Ligand-targeted
5%
Elongin C
5%
Isoform Switching
5%
Hypoxic Signaling
5%
Thioamide
5%
Pluripotent
5%
Ubiquitin System
5%
Mode of Action
5%
Resistance Mechanisms
5%
Structure-based Lead Discovery
5%
CUL5
5%
Impurities
5%
Degradation Rate
5%
Lineage Specification
5%
RNA-seq Analysis
5%
Smad2
5%
Allosteric Targeting
5%
Iterative Design
5%
Cyclohexyl
5%
19F NMR
5%
Sex-determining Region Y-box 2 (SOX2)
5%
Synthetic Chemistry
5%
Bifunctional Ligand
5%
Structure Optimization
5%
Warhead
5%
Multimeric Complexes
5%
Conformational Flexibility
5%
Genetic Approach
5%
Trivalent
5%
Ubiquitin Ligase
5%
Mechanistic Aspects
5%
Dissociation Kinetics
5%
Inducible Degradation
5%
Druggability
5%
Fragment Binding
5%
Gli1
5%
Hypoxia Response
5%
Zinc
5%
Structural Biology
5%
Fragment Library
5%
Intracellular Level
5%
Selective Intervention
5%
Displacement Assay
5%
Missile System
5%
Structural Diversity
5%
Subunit Assembly
5%
Reporter System
5%
Small Molecule Libraries
5%
Endosomal
5%
Carboxamide
5%
Cullin-RING
5%
Plant Homeodomain
5%
BRD7
5%
Structural Rearrangement
5%
BRD9
5%
Non-canonical
5%
Crystal Lattice
5%
Computational Methods
5%
New Frontiers
5%
Pyrrolidine-2
5%
Group-based
5%
Screening Method
5%
SOCS Box
5%
Ankyrin Repeat
5%
Inhibitor Binding
5%
Dynamic Combinatorial Chemistry
5%
Iterative Optimization
5%
Melanoma
5%
Stability Level
5%
Bump-hole
5%
Phenylene
5%
Transcriptional Complex
5%
Fragment-based Approach
5%
Phosphonates
5%
Fluoro
5%
Stabilizer
5%
Covalent Ligand
5%
RBX1
5%
Self-degradation
5%
Universal Reporter
5%
NanoLuc
5%
Inhibitor Scaffold
5%
Stereochemical Inversion
5%
Isoform-specific
5%
Benzyl
5%
Stereoselective Synthesis
5%
Prolyl Hydroxylase
5%
Pathway Inhibitors
5%
Structural Insights
5%
Stereoselective Recognition
5%
Tetrahydroquinoline
5%
Cooperative Recognition
5%
Conformational Analysis
5%
Hedgehog
5%
Biochemistry, Genetics and Molecular Biology
Ubiquitin-Conjugating Enzyme
88%
Proteolysis
84%
Ubiquitin Ligase
70%
Small Molecule
58%
Ternary Complex
51%
Protein Catabolism
40%
Bromodomain
33%
Cullin
30%
Crystal Structure
29%
Ubiquitination
25%
Protein-Protein Interaction
25%
Hypoxia-Inducible Factors
21%
Cytokine
20%
Isoform
16%
Molecular Recognition
16%
BRD4
16%
Ubiquitin
15%
Cooperation
15%
Molecular Glue
15%
Conformation
14%
Hypoxia Inducible Factor 1
13%
Solution and Solubility
12%
Elongin
12%
Binding Affinity
11%
Procollagen-Proline Dioxygenase
11%
Ligase
10%
Homeodomain
10%
Allele
10%
Proteasome
9%
Structure Activity Relation
9%
X-Ray Crystallography
9%
Proteomics
9%
Tumor Suppressor Protein
7%
Enzyme Inhibitor
7%
Proteome
7%
BRD2
7%
Isothermal Titration Calorimetry
7%
Nuclear Magnetic Resonance Spectroscopy
7%
Complex Formation
6%
Biological Functions
6%
Chemical Genetics
6%
Targeting Protein
6%
Enzyme
6%
CRISPR/Cas9
6%
Transcription Factors
6%
Avidity
6%
Hydroxylation
6%
Histone H3
6%
Epigenomics
6%
Epigenetics
6%
Cancer Cell
5%
Alpha Chain
5%
Histone
5%
Cereblon
5%
Oxygen Sensing
5%
SOX2
5%
Multiprotein Complex
5%
GLI1
5%
Zinc Finger Motif
5%
X Ray
5%
Genetic Approach
5%
Von Hippel-Lindau Disease
5%
Mitochondrial Disease
5%
Proline
5%
Ankyrin
5%
Necroptosis
5%
Ankyrin Repeat
5%
Protein Kinase B
5%
Gene Linkage
5%
RNA Sequencing
5%
Thioamide
5%
Kinase
5%
Phosphotransferase
5%
Regulatory Element
5%
Dynamic Combinatorial Chemistry
5%