Keyphrases
Proteolysis Targeting chimera (PROTAC)
96%
Von Hippel-Lindau
60%
E3 Ubiquitin Ligase
56%
Degrader
47%
E3 Ligase
47%
Ternary Complex
39%
Structure-based Design
28%
Bromodomain-containing Protein 4 (BRD4)
27%
Small Molecules
25%
Protein-protein Interaction
25%
Chemical Probes
25%
Cullin-RING E3 Ligase
25%
Bromodomain
22%
Targeted Protein Degradation
19%
Suppressor of Cytokine Signaling 2
19%
Protein Degradation
15%
Fragment Screening
14%
Hypoxia-inducible factor-1α (HIF-1α)
13%
Ubiquitination
13%
Molecular Recognition
12%
Cooperativity
12%
Bromo
12%
Protein Degraders
11%
BRD2
11%
Linker
11%
Targeted Degradation
10%
Hypoxia-inducible Factor
10%
Cullin 5
10%
Phosphotyrosine
10%
Molecular Glue
10%
Substrate Receptors
10%
Small Molecule Inhibitors
10%
Ubiquitin-proteasome System
10%
Binding Affinity
10%
Deubiquitinating Enzyme
9%
Hydroxyproline
9%
Knockdown
9%
VH298
9%
Structure-activity Relationship
8%
UBE2T
8%
Dimerizer
8%
Biophysical Studies
8%
X-ray Crystallography
8%
Elongin
8%
Substrate Recognition
7%
SGK3
7%
PROTAC Degraders
7%
Bifunctional
7%
Small Molecule Ligands
7%
Drug Discovery
7%
Co-crystal Structure
7%
Adaptor
7%
Full-size
7%
Von Hippel-Lindau Disease
7%
Protein Complex
7%
Fanconi Anemia
7%
Protein of Interest
7%
Bromodomain Inhibitors
7%
Ligase
7%
Bump
6%
Cullin2
6%
Selective Degradation
6%
Isothermal Titration Calorimetry
6%
Binder
6%
Chemical Genetics
6%
Proteasomal Degradation
6%
Nuclear Magnetic Resonance
6%
Multisubunit
6%
Targeted Protein Degraders
6%
Target Molecule
6%
Rapid Degradation
6%
Extra-terminal Domain
6%
Plant Homeodomain Finger
6%
Histone H3 Tail
6%
Recent Advances
6%
Structural Features
6%
Zinc Finger
6%
E3 Ligase Ligands
5%
Small Molecule Targeting
5%
Epigenetics
5%
Multisubunit Complexes
5%
Alpha Subunit
5%
HaloPROTAC
5%
Bromodomain Proteins
5%
Hydroxylation
5%
Medicinal Chemistry
5%
Induced Degradation
5%
Biophysical Methods
5%
Cereblon
5%
Hijacking
5%
Small Molecule Degrader
5%
CRL Complex
5%
Allele-specific
5%
Ternary Complex Formation
5%
Drug Target
5%
Ligand-targeted
5%
Biochemistry, Genetics and Molecular Biology
Protein Catabolism
100%
Ubiquitin-Conjugating Enzyme
83%
Ligase
67%
Small Molecule
53%
Ternary Complex
47%
Bromodomain
31%
Cullin
28%
Crystal Structure
28%
Ubiquitination
24%
Protein-Protein Interaction
24%
Hypoxia-Inducible Factors
20%
Cytokine
19%
Isoform
15%
Molecular Recognition
15%
BRD4
15%
Ubiquitin
15%
Cooperation
14%
Conformation
14%
Hypoxia Inducible Factor 1
13%
Elongin
11%
Binding Affinity
11%
Procollagen-Proline Dioxygenase
10%
Solution and Solubility
10%
Homeodomain
9%
Allele
9%
Proteasome
9%
Structure Activity Relation
8%
Proteomics
8%
X-Ray Crystallography
8%
Tumor Suppressor Protein
7%
Enzyme Inhibitor
7%
Magnetism
7%
BRD2
7%
Isothermal Titration Calorimetry
6%
Biological Functions
6%
Complex Formation
6%
Chemical Genetics
6%
Targeting Protein
6%
Enzyme
6%
CRISPR/Cas9
6%
Transcription Factors
6%
Avidity
6%
Hydroxylation
6%
Histone H3
5%
Proteome
5%
Epigenomics
5%
Epigenetics
5%
Cancer Cell
5%
Alpha Chain
5%
Histone
5%
Cereblon
5%
Signal Transduction
5%