DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

Ciulli, Alessio (Investigator)

Centre for Targeted Protein Degradation

45 Article
7 Review article
1 Chapter (peer-reviewed)
1 Letter

7 results

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2023
Breaking free from the crystal lattice: Structural biology in solution to study protein degraders
Haubrich, K., Spiteri, V., Farnaby, W., Sobott, F. & Ciulli, A. (Lead / Corresponding author), Apr 2023, In: Current Opinion in Structural Biology. 79, 9 p., 102534.
Research output: Contribution to journal › Review article › peer-review

Open Access
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4 Citations (Scopus)

113 Downloads (Pure)
2022
Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders
Diehl, C. J. & Ciulli, A. (Lead / Corresponding author), 19 Aug 2022, In: Chemical Society Reviews. 51, 19, p. 8216-8257 42 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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62 Citations (Scopus)

161 Downloads (Pure)
2021
Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
Ramachandran, S. & Ciulli, A. (Lead / Corresponding author), Apr 2021, In: Current Opinion in Structural Biology. 67, p. 110-119 10 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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33 Citations (Scopus)

807 Downloads (Pure)
Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues
Makukhin, N. & Ciulli, A. (Lead / Corresponding author), Jan 2021, In: RSC Medicinal Chemistry. 12, 1, p. 8-23 16 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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17 Citations (Scopus)

118 Downloads (Pure)
2019
Bifunctional chemical probes inducing protein-protein interactions
Maniaci, C. & Ciulli, A. (Lead / Corresponding author), Oct 2019, In: Current Opinion in Chemical Biology. 52, p. 145-156 12 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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74 Citations (Scopus)

594 Downloads (Pure)
2017
Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders
Hughes, S. J. & Ciulli, A. (Lead / Corresponding author), 8 Nov 2017, In: Essays in Biochemistry. 61, 5, p. 505-516 12 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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154 Citations (Scopus)

629 Downloads (Pure)
2016
Chemical genetics approaches for selective intervention in epigenetics
Runcie, A. C., Chan, K. H., Zengerle, M. & Ciulli, A. (Lead / Corresponding author), Aug 2016, In: Current Opinion in Chemical Biology. 33, p. 186-194 9 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
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22 Citations (Scopus)

265 Downloads (Pure)

DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

Research output

Search results

Breaking free from the crystal lattice: Structural biology in solution to study protein degraders

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues

Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues

Bifunctional chemical probes inducing protein-protein interactions

Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

Chemical genetics approaches for selective intervention in epigenetics