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Dynamics of Eukaryotic Junction-Resolving Enzyme GEN1 - DNA Junction Interactions
Lilley, David
(Investigator)
Nucleic Acid Structure
Overview
Fingerprint
Research Outputs
(17)
Project Details
Status
Finished
Effective start/end date
1/10/16
→
30/09/19
Funding
Biotechnology and Biological Sciences Research Council
(BB/P001491/1):
£344,154.00
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Riboswitch
Medicine & Life Sciences
100%
RNA
Medicine & Life Sciences
61%
Guanidine
Medicine & Life Sciences
60%
Ions
Medicine & Life Sciences
54%
Cruciform DNA
Medicine & Life Sciences
53%
Small Nucleolar Ribonucleoproteins
Medicine & Life Sciences
45%
Enzymes
Medicine & Life Sciences
37%
Adenine
Medicine & Life Sciences
33%
Research output
Research output per year
2016
2016
2017
2020
13
Article
3
Review article
1
Editorial
Research output per year
Research output per year
Human ANKLE1 is a nuclease specific for branched DNA
Song, J.
,
Freeman, A. D. J.
,
Knebel, A.
,
Gartner, A.
&
Lilley, D. M. J.
,
2 Oct 2020
,
In:
Journal of Molecular Biology.
432
,
21
,
p. 5825-5834
10 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
DNA
100%
Chromatids
90%
Chromosome Segregation
44%
Caenorhabditis elegans
39%
Enzymes
39%
5
Citations (Scopus)
21
Downloads (Pure)
Junction resolving enzymes use multivalency to keep the Holliday junction dynamic
Zhou, R.
,
Yang, O.
,
Declais, A-C.
,
Jin, H.
,
Gwon, G. H.
,
Freeman, A.
,
Cho, Y.
,
Lilley, D.
&
Ha, T.
,
1 Mar 2019
,
In:
Nature Chemical Biology.
15
,
3
,
p. 269-275
7 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Cruciform DNA
100%
Enzymes
35%
Genetic Recombination
20%
Bacteriophage T7
15%
Fluorescence Resonance Energy Transfer
14%
9
Citations (Scopus)
92
Downloads (Pure)
A monovalent ion in the DNA binding interface of the eukaryotic junction-resolving enzyme GEN1
Liu, Y.
,
Freeman, A. D. J.
,
Déclais, A-C.
&
Lilley, D. M. J.
,
16 Nov 2018
,
In:
Nucleic Acids Research.
46
,
20
,
p. 11089-11098
10 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Ions
100%
DNA
67%
Substrate Specificity
67%
Enzymes
66%
Catalytic Domain
54%
5
Citations (Scopus)
95
Downloads (Pure)