Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

Cohen, Philip (Investigator)

MRC PPU

16 Article
1 Comment/debate
1 Review article

18 results

2015
An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice
Akbar, N., Nanda, S., Belch, J., Cohen, P. & Khan, F. (Lead / Corresponding author), 4 Feb 2015, In: Arthritis Research & Therapy. 17, 10 p., 22.
Research output: Contribution to journal › Article › peer-review

Open Access
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11 Link opens in a new tab Citations (Scopus)

454 Downloads (Pure)
Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)
Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
65 Link opens in a new tab Citations (Scopus)
Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting
Emmerich, C. H. (Lead / Corresponding author) & Cohen, P., 9 Oct 2015, In: Biochemical and Biophysical Research Communications. 466, 1, p. 1-14 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
106 Link opens in a new tab Citations (Scopus)
Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members
Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. (Lead / Corresponding author), 15 Jun 2015, In: Biochemical Journal. 468, 3, p. 363-372 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
11 Link opens in a new tab Citations (Scopus)
The promise and peril of chemical probes
Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M. (Lead / Corresponding author) & Frederiksen, M. & 34 others, Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J., Aug 2015, In: Nature Chemical Biology. 11, 8, p. 536-541 6 p.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
694 Link opens in a new tab Citations (Scopus)
2014
An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. (Lead / Corresponding author), 1 Aug 2014, In: Biochemical Journal. 461, 3, p. 531-537 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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93 Link opens in a new tab Citations (Scopus)

321 Downloads (Pure)
Immune diseases caused by mutations in kinases and components of the ubiquitin system
Cohen, P., Jun 2014, In: Nature Immunology. 15, 6, p. 521-529 9 p.
Research output: Contribution to journal › Review article › peer-review
35 Link opens in a new tab Citations (Scopus)
IRAK-1 bypasses priming and directly links TLRs torapid NLRP3 inflammasome activation
Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., 14 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 775-780 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
243 Link opens in a new tab Citations (Scopus)
Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells
Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P. (Lead / Corresponding author), 9 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17432-17437 6 p.
Research output: Contribution to journal › Article › peer-review
89 Link opens in a new tab Citations (Scopus)
The TLR and IL-1 signalling network at a glance
Cohen, P., Jun 2014, In: Journal of Cell Science. 127, 11, p. 2383-2390 8 p.
Research output: Contribution to journal › Article › peer-review
165 Link opens in a new tab Citations (Scopus)
2013
ABIN1 dysfunction as a genetic basis for lupus nephritis
Caster, D. J., Korte, E. A., Nanda, S. K., McLeish, K. R., Oliver, R. K., G'Sell, R. T., Sheehan, R. M., Freeman, D. W., Coventry, S. C., Kelly, J. A., Guthridge, J. M., James, J. A., Sivils, K. L., Alarcon-Riquelme, M. E., Scofield, R. H., Adrianto, I., Gaffney, P. M., Stevens, A. M., Freedman, B. I. & Langefeld, C. D. & 25 others, Tsao, B. P., Pons-Estel, B. A., Jacob, C. O., Kamen, D. L., Gilkeson, G. S., Brown, E. E., Alarcon, G. S., Edberg, J. C., Kimberly, R. P., Martin, J., Merrill, J. T., Harley, J. B., Kaufman, K. M., Reveille, J. D., Anaya, J. M., Criswell, L. A., Vila, L. M., Petri, M., Ramsey-Goldman, R., Bae, S. C., Boackle, S. A., Vyse, T. J., Niewold, T. B., Cohen, P. & Powell, D. W., 1 Nov 2013, In: Journal of the American Society of Nephrology. 24, 11, p. 1743-1754 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
71 Link opens in a new tab Citations (Scopus)
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. (Lead / Corresponding author), 17 Sept 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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383 Link opens in a new tab Citations (Scopus)

288 Downloads (Pure)
DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA
Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P., 23 Aug 2013, In: Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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28 Link opens in a new tab Citations (Scopus)

256 Downloads (Pure)
Kinase drug discovery: What's next in the field?
Cohen, P. & Alessi, D. R., 2013, In: ACS Chemical Biology. 8, 1, p. 96-104 9 p.
Research output: Contribution to journal › Article › peer-review
342 Link opens in a new tab Citations (Scopus)
Molecular control of the NEMO family of ubiquitin-binding proteins
Clark, K., Nanda, S. & Cohen, P., 2013, In: Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.
Research output: Contribution to journal › Article › peer-review
105 Link opens in a new tab Citations (Scopus)
The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases
Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K., 2013, In: FEBS Journal. 280, 12, p. 2830-2841 12 p.
Research output: Contribution to journal › Article › peer-review
53 Link opens in a new tab Citations (Scopus)
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system
Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P., 1 May 2013, In: Biochemical Journal. 451, 3, p. 427-437 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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183 Link opens in a new tab Citations (Scopus)

275 Downloads (Pure)
Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice
Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S. C. & Cohen, P. (Lead / Corresponding author), 2013, In: Journal of Immunology. 1203268.
Research output: Contribution to journal › Article › peer-review
83 Link opens in a new tab Citations (Scopus)

Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

Research output

Search results

2015

2014

2013