Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

2015

An important role for A20-binding inhibitor of nuclear factor-kB-1 (ABIN1) in inflammation-mediated endothelial dysfunction: an in vivo study in ABIN1 (D485N) mice

Akbar, N., Nanda, S., Belch, J., Cohen, P. & Khan, F. (Lead / Corresponding author), 4 Feb 2015, In: Arthritis Research & Therapy. 17, 10 p., 22.

Research output: Contribution to journal › Article › peer-review

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9 Citations (Scopus)

426 Downloads (Pure)

Discovery of type II inhibitors of tgfβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Tan, L., Nomanbhoy, T., Gurbani, D., Patricelli, M., Hunter, J., Geng, J., Herhaus, L., Zhang, J., Pauls, E., Ham, Y., Choi, H. G., Xie, T., Deng, X., Buhrlage, S. J., Sim, T., Cohen, P., Sapkota, G., Westover, K. D. & Gray, N. S., 8 Jan 2015, In: Journal of Medicinal Chemistry. 58, 1, p. 183-196 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Citations (Scopus)

Optimising methods for the preservation, capture and identification of ubiquitin chains and ubiquitylated proteins by immunoblotting

Emmerich, C. H. (Lead / Corresponding author) & Cohen, P., 9 Oct 2015, In: Biochemical and Biophysical Research Communications. 466, 1, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Citations (Scopus)

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members

Malik, N., Vollmer, S., Nanda, S. K., Lopez-Pelaez, M., Prescott, A., Gray, N. & Cohen, P. (Lead / Corresponding author), 15 Jun 2015, In: Biochemical Journal. 468, 3, p. 363-372 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M. (Lead / Corresponding author) & Frederiksen, M. & 34 others, Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Roth, B., Ross, R., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N. & Zuercher, W. J., Aug 2015, In: Nature Chemical Biology. 11, 8, p. 536-541 6 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

650 Citations (Scopus)

2014

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

Zhang, J., Clark, K., Lawrence, T., Peggie, M. W. & Cohen, P. (Lead / Corresponding author), 1 Aug 2014, In: Biochemical Journal. 461, 3, p. 531-537 7 p.

Research output: Contribution to journal › Article › peer-review

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85 Citations (Scopus)

276 Downloads (Pure)

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Cohen, P., Jun 2014, In: Nature Immunology. 15, 6, p. 521-529 9 p.

Research output: Contribution to journal › Review article › peer-review

35 Citations (Scopus)

IRAK-1 bypasses priming and directly links TLRs torapid NLRP3 inflammasome activation

Lin, K. M., Hu, W., Troutman, T. D., Jennings, M., Brewer, T., Li, X., Nanda, S., Cohen, P., Thomas, J. A. & Pasare, C., 14 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 2, p. 775-780 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

229 Citations (Scopus)

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells

Lopez Pelaez, M., Lamont, D. J., Peggie, M., Shpiro, N., Gray, N. S. & Cohen, P. (Lead / Corresponding author), 9 Dec 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 49, p. 17432-17437 6 p.

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

The TLR and IL-1 signalling network at a glance

Cohen, P., Jun 2014, In: Journal of Cell Science. 127, 11, p. 2383-2390 8 p.

Research output: Contribution to journal › Article › peer-review

153 Citations (Scopus)

2013

ABIN1 dysfunction as a genetic basis for lupus nephritis

Caster, D. J., Korte, E. A., Nanda, S. K., McLeish, K. R., Oliver, R. K., G'Sell, R. T., Sheehan, R. M., Freeman, D. W., Coventry, S. C., Kelly, J. A., Guthridge, J. M., James, J. A., Sivils, K. L., Alarcon-Riquelme, M. E., Scofield, R. H., Adrianto, I., Gaffney, P. M., Stevens, A. M., Freedman, B. I. & Langefeld, C. D. & 25 others, Tsao, B. P., Pons-Estel, B. A., Jacob, C. O., Kamen, D. L., Gilkeson, G. S., Brown, E. E., Alarcon, G. S., Edberg, J. C., Kimberly, R. P., Martin, J., Merrill, J. T., Harley, J. B., Kaufman, K. M., Reveille, J. D., Anaya, J. M., Criswell, L. A., Vila, L. M., Petri, M., Ramsey-Goldman, R., Bae, S. C., Boackle, S. A., Vyse, T. J., Niewold, T. B., Cohen, P. & Powell, D. W., 1 Nov 2013, In: Journal of the American Society of Nephrology. 24, 11, p. 1743-1754 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Citations (Scopus)

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

Emmerich, C. H., Ordureau, A., Strickson, S., Arthur, J. S. C., Pedrioli, P. G. A., Komander, D. & Cohen, P. (Lead / Corresponding author), 17 Sept 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 38, p. 15247-15252 6 p.

Research output: Contribution to journal › Article › peer-review

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365 Citations (Scopus)

225 Downloads (Pure)

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P. R. & Cohen, P., 23 Aug 2013, In: Journal of Biological Chemistry. 288, 34, p. 24569-24580 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

214 Downloads (Pure)

Kinase drug discovery: What's next in the field?

Cohen, P. & Alessi, D. R., 2013, In: ACS Chemical Biology. 8, 1, p. 96-104 9 p.

Research output: Contribution to journal › Article › peer-review

334 Citations (Scopus)

Molecular control of the NEMO family of ubiquitin-binding proteins

Clark, K., Nanda, S. & Cohen, P., 2013, In: Nature Reviews Molecular Cell Biology. 14, p. 673-685 13 p.

Research output: Contribution to journal › Article › peer-review

99 Citations (Scopus)

The anti-inflammatory compound BAY-11-7082 is a potent inhibitor of protein tyrosine phosphatases

Krishnan, N., Bencze, G., Cohen, P. & Tonks, N. K., 2013, In: FEBS Journal. 280, 12, p. 2830-2841 12 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

Strickson, S., Campbell, D. G., Emmerich, C. H., Knebel, A., Plater, L., Ritorto, M. S., Shpiro, N. & Cohen, P., 1 May 2013, In: Biochemical Journal. 451, 3, p. 427-437 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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170 Citations (Scopus)

220 Downloads (Pure)

Two Phases of Inflammatory Mediator Production Defined by the Study of IRAK2 and IRAK1 Knock-in Mice

Pauls, E., Nanda, S. K., Smith, H., Toth, R., Arthur, J. S. C. & Cohen, P. (Lead / Corresponding author), 2013, In: Journal of Immunology. 1203268.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

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