Establishing the mechanism underlying the genetic association of a glucose transporter to metformin response to improve its use in the clinic.

Ashford, Michael (Investigator)
McCrimmon, Rory (Investigator)
Pearson, Ewan (Investigator)
Sutherland, Calum (Investigator)

Status	Finished
Effective start/end date	1/06/17 → 31/03/21

Funding

Diabetes UK (16/0005487): £282,456.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

1 Article

Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression
Morrice, N., Vainio, S., Mikkola, K., van Aalten, L., Gallagher, J. R., Ashford, M. L. J., McNeilly, A. D., McCrimmon, R. J., Grosfeld, A., Serradas, P., Koffert, J., Pearson, E. R., Nuutila, P. & Sutherland, C., 15 Sept 2023, (E-pub ahead of print) In: Molecular Metabolism. 101807.
Research output: Contribution to journal › Article › peer-review

Open Access

Establishing the mechanism underlying the genetic association of a glucose transporter to metformin response to improve its use in the clinic.

Project Details

Funding

UN Sustainable Development Goals

Research output

Metformin increases the uptake of glucose into the gut from the circulation in high-fat diet-fed male mice, which is enhanced by a reduction in whole-body Slc2a2 expression