Keyphrases
Proteolysis Targeting chimera (PROTAC)
100%
Degrader
52%
E3 Ligase
43%
Targeted Protein Degradation
26%
Ternary Complex
18%
Protein Degraders
16%
Ubiquitination
16%
Linker
16%
Small Molecules
15%
E3 Ligase Ligands
14%
E3 Ubiquitin Ligase
14%
Phosphotyrosine
14%
Von Hippel-Lindau
13%
Ligase
13%
Bromodomain-containing Protein 4 (BRD4)
11%
Rational Design
11%
In Cancer
11%
Chemical Probes
10%
Druggability
10%
Molecular Glue
10%
Conformational Change
9%
Cereblon
8%
PROTAC Degraders
8%
Recent Advances
8%
Prodrug
8%
Small Molecule Inhibitors
8%
Phosphonates
7%
Esters
7%
Proximity-based
7%
Selective Degradation
7%
Leucine-rich Repeat Kinase 2 (LRRK2)
7%
Medicinal Chemistry
7%
Binding Affinity
7%
Drug Discovery
7%
Cancer Treatment
7%
Nuclear Magnetic Resonance Chemical Shifts
6%
Automatic Determination
6%
Ligand-targeted
6%
Bump-hole
6%
Phenylene
6%
Structure-based Design
6%
Covalent Ligand
6%
Suppressor of Cytokine Signaling 2
6%
Stereochemical Inversion
6%
Target Molecule
6%
Structural Variation
6%
Picasso
6%
Structural Diversity
6%
Subunit Assembly
6%
Chemical Shift Perturbation
6%
Human Proteome
6%
Screening Experiment
6%
Penetrant
6%
KLHL3
6%
Crystal Lattice
6%
Degron
6%
Amides
6%
Multisubunit
6%
Cell Behavior
6%
Knockdown
6%
Dynamic Combinatorial Chemistry
6%
Cyclohexyl
6%
Imidazo
6%
Rapid Degradation
6%
Synthetic Chemistry
6%
HiBiT
6%
Orally Bioavailable
6%
Pyridazine
6%
Stabilizer
6%
Ligand Screening
6%
Cellular Thermal Shift Assay (CETSA)
6%
DYRK Kinase
6%
WNK Kinase
6%
Structural Biology
6%
Hypoxia-inducible factor-1α (HIF-1α)
6%
Epigenetic Modulators
6%
Sequence Variation
6%
Blood-brain Barrier
6%
Web Server
6%
Crystallographic Study
6%
Biophysical Studies
6%
Protein Degradation
6%
ABCC1
6%
Chimera Protein
6%
Distinct Mechanism
6%
AMP-activated Protein Kinase
6%
SOCS1
6%
Family Protein
6%
Cancer Cells
6%
Multidrug Resistance Protein 1 (MDR1)
6%
Patent Review
6%
Efflux Pump
6%
Patient-derived
6%
Public-private Partnership
6%
Molecular Hinge
6%
Hepatitis C Virus
6%
Cyclophilin A
6%
Macrocycles
6%
Human Immunodeficiency Virus Type 1 (HIV-1)
6%
Ferrocene
6%
Biological Function
6%
Human Proteins
5%
Protein Targeting
5%
WNK3
5%
Induced Proximity
5%
Cancer Types
5%
Structure-activity Relationship
5%
Biochemistry, Genetics and Molecular Biology
Proteolysis
87%
Ubiquitin Ligase
60%
Protein Catabolism
37%
Ternary Complex
24%
Ubiquitination
23%
Small Molecule
23%
Crystal Structure
17%
Ubiquitin-Conjugating Enzyme
15%
Ligase
14%
Molecular Glue
14%
Cytokine
13%
Proteome
10%
Biological Functions
9%
Conformational Change
9%
Conformation
8%
Cereblon
8%
Posttranslational Modification
8%
Chemogenomics
8%
Ubiquitin
7%
Binding Affinity
7%
Kelch Motif
6%
Protein Denaturation
6%
Hypoxia Inducible Factor 1
6%
Biological Phenomena and Functions Concerning the Entire Organism
6%
Leucine-Rich Repeat
6%
Amino Acid Substitution
6%
WNK1
6%
Blood Brain Barrier
6%
Kinase
6%
Phosphotransferase
6%
Epigenetics
6%
Solution and Solubility
6%
Proline
6%
ABCC1
6%
AMP-activated Protein Kinase
6%
BRD4
6%
Cancer Cell
6%
Protein Family
6%
Dynamic Combinatorial Chemistry
6%
Mass Spectrometry
5%
Cryoelectron Microscopy
5%