Extending The Jalview Resource for Biological Sequence Alignment and Analysis (Biomedical Resource application)

Barton, Geoffrey (Investigator)

Computational Biology

9 Article
3 Preprint
1 Chapter (peer-reviewed)

13 results

2026
Mutations within the predicted 1 fragment-binding region of FAM83G/SACK1G abolish its interaction with the Ser/Thr kinase CK1α
Utges, J. S., Lee Zhi Xuan, D., Le Chatelier, B., Glennie, L., Macartney, T. J., Wood, N. T., Barton, G. J. (Lead / Corresponding author) & Sapkota, G. P. (Lead / Corresponding author), 7 Jan 2026, In: Open Biology. 16, 1, 250230.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2025
LIGYSIS-web: a resource for the analysis of protein-ligand binding sites
S Utgés, J., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), 7 Jul 2025, In: Nucleic Acids Research. 53, W1, p. W351-W360 10 p., gkaf411.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Link opens in a new tab Citations (Scopus)

48 Downloads (Pure)
2024
A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites
MacGowan, S. A., Madeira, F., Britto-Borges, T. & Barton, G. J. (Lead / Corresponding author), 11 Apr 2024, (E-pub ahead of print) In: Communications Biology. 7, 10 p., 447.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Link opens in a new tab Citations (Scopus)

122 Downloads (Pure)
Classification of likely functional class for ligand binding sites identified from fragment screening
Utgés, J. S., MacGowan, S. A., Ives, C. M. & Barton, G. J. (Lead / Corresponding author), 13 Mar 2024, In: Communications Biology. 7, 13 p., 320.
Research output: Contribution to journal › Article › peer-review

Open Access
File
8 Link opens in a new tab Citations (Scopus)

146 Downloads (Pure)
Comparative evaluation of methods for the prediction of protein-ligand binding sites
S. Utges, J. & Barton, G. J. (Lead / Corresponding author), 11 Nov 2024, In: Journal of Cheminformatics. 16, 35 p., 126.
Research output: Contribution to journal › Article › peer-review

Open Access
File
15 Link opens in a new tab Citations (Scopus)

171 Downloads (Pure)
2022
Missense variants in human ACE2 strongly affect binding to SARS-CoV-2 Spike providing a mechanism for ACE2 mediated genetic risk in Covid-19: A case study in affinity predictions of interface variants
MacGowan, S. A., Barton, M. I., Kutuzov, M., Dushek, O., van der Merwe, P. A. & Barton, G. J. (Lead / Corresponding author), 2 Mar 2022, In: PLoS Computational Biology. 18, 3, p. 1-25 25 p., e1009922.
Research output: Contribution to journal › Article › peer-review

Open Access
File
11 Link opens in a new tab Citations (Scopus)

150 Downloads (Pure)
2021
Alignment of Biological Sequences with Jalview
Procter, J. B. (Lead / Corresponding author), Carstairs, G. M., Soares, B., Mourão, K., Ofoegbu, T. C., Barton, D., Lui, L., Menard, A., Sherstnev, N., Roldan-Martinez, D., Duce, S., Martin, D. M. A. & Barton, G. J., 2021, Multiple Sequence Alignment: Methods and Protocols. Katoh, K. (ed.). 1 ed. New York: Humana Press, p. 203-224 22 p. (Methods in Molecular Biology; vol. 2231).
Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Open Access
File
139 Link opens in a new tab Citations (Scopus)

307 Downloads (Pure)
Ankyrin repeats in context with human population variation
Utgés,, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), Aug 2021, In: PLoS Computational Biology. 17, 8, 26 p., e1009335.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Link opens in a new tab Citations (Scopus)

175 Downloads (Pure)
Ankyrin repeats in context with human population variation
Utgés, J. S., Tsenkov, M. I., Dietrich, N. J. M., MacGowan, S. A. & Barton, G. J. (Lead / Corresponding author), 30 May 2021, BioRxiv, 26 p.
Research output: Working paper/Preprint › Preprint

Open Access
File
101 Downloads (Pure)
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S. A., Kutuzov, M. A., Dushek, O., Barton, G. J. (Lead / Corresponding author) & van der Merwe, P. A. (Lead / Corresponding author), Aug 2021, In: eLife. 10, 19 p., e70658.
Research output: Contribution to journal › Article › peer-review

Open Access
File
275 Link opens in a new tab Citations (Scopus)

167 Downloads (Pure)
Effects of common mutations in the SARS-CoV-2 Spike RBD domain and its ligand the human ACE2 receptor on binding affinity and kinetics
Barton, M. I., MacGowan, S., Kutuzov, M., Dushek, O., Barton, G. J. (Lead / Corresponding author) & Merwe, P. A. V. D. (Lead / Corresponding author), 24 May 2021, BioRxiv, 39 p.
Research output: Working paper/Preprint › Preprint

File
152 Downloads (Pure)
Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike
MacGowan, S. A., Barton, M. I. (Lead / Corresponding author), Kutuzov, M., Dushek, O., Merwe, P. A. V. D. & Barton, G. J., 21 May 2021, BioRxiv, 28 p.
Research output: Working paper/Preprint › Preprint

File
131 Downloads (Pure)
2020
The Dundee Resource for Sequence Analysis and Structure Prediction
MacGowan, S., Madeira, F., Britto-Borges, T., Warowny, M., Drozdetskiy, A., Procter, J. & Barton, G. (Lead / Corresponding author), Jan 2020, In: Protein Science. 29, 1, p. 277-297 21 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Link opens in a new tab Citations (Scopus)

168 Downloads (Pure)

Extending The Jalview Resource for Biological Sequence Alignment and Analysis (Biomedical Resource application)

Research output

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2026

2025

2024

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2021

2020