Functional and Structural Studies of the Streptococcal Virulence Factor Group A Carbohydrate Biosynthesis Pathway (Sir Henry Dale Fellowship)

Project Details

StatusActive
Effective start/end date1/04/1614/10/21

Funding

  • Wellcome Trust (109357/Z/15/Z): £1,105,898.00

Research Output

Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-β-L-rhamnose biosynthesis in microalgae

Wagstaff, B., Rejzek, M., Kuhaudomlarp, S., Hill, L., Mascia, I., Nepogodiev, S. A., Dorfmueller, H. & Field, R. A., 7 Jun 2019, In : Journal of Biological Chemistry. 294, 23, p. 9172-9185 14 p.

Research output: Contribution to journalArticle

Open Access
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  • 1 Citation (Scopus)
    117 Downloads (Pure)

    Group A, B, C, and G Streptococcus Lancefield antigen biosynthesis is initiated by a conserved α-D-GlcNAc-β-1,4-L-rhamnosyltransferase

    Zorzoli, A., Meyer, B. H., Adair, E., Torgov, V. I., Veselovsky, V. V., Danilov, L. L., Uhrin, D. & Dorfmueller, H. C., 18 Oct 2019, In : Journal of Biological Chemistry. 294, 42, p. 15237-15256 20 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 1 Citation (Scopus)
    36 Downloads (Pure)

    Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification

    van der Beek, S. L., Zorzoli, A., Çanak, E., Chapman, R. N., Lucas, K., Meyer, B. H., Evangelopoulos, D., de Carvalho, L. P. S., Boons, G-J., Dorfmueller, H. C. & van Sorge, N. M., Apr 2019, In : Molecular Microbiology. 111, 4, p. 951-964 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    144 Downloads (Pure)