Functional Dissection of the Eukaryotic Replisome (Senior Investigator Award)

Research output

Research output per year 2014 2014 2015 2016 2017 2018 2019 2022

• 21 Article

Research output per year

Research output per year

Search results

• 2022

  Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II

  Evrin, C., Serra-Cardona, A., Duan, S., Mukherjee, P. P., Zhang, Z. & Labib, K. P. M., 1 Mar 2022, In: EMBO Journal. 41, 5, p. 1-14 14 p., e109783.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • RNA Polymerase II 100%
  • Histone 92%
  • Histones 80%
  • Chromatin 75%
  • Nucleosomes 75%
  8 Citations (Scopus)

  89 Downloads (Pure)
• 2021

  CUL2^LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle

  Villa, F., Fujisawa, R., Ainsworth, J., Nishimura, K., Lie-A-Ling, M., Lacaud, G. & Labib, K., 3 Mar 2021, In: EMBO Reports. 22, 3, 13 p., e52164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ligases 100%
  • Ubiquitination 98%
  • Mammalian Cell 94%
  • Ubiquitin 91%
  • Cell Cycle 71%
  12 Citations (Scopus)

  151 Downloads (Pure)
• 2020

  CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold

  Deegan, T. D., Mukherjee, P. P., Fujisawa, R., Polo Rivera, C. & Labib, K. P. M., 17 Aug 2020, In: eLife. 9, 33 p., e60371.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA synthesome 100%
  • DNA Structure 62%
  • Ubiquitination 57%
  • Ubiquitin 53%
  • DNA Replication 53%
  36 Citations (Scopus)

  92 Downloads (Pure)
• 2019

  In vitro reconstitution defines the minimal requirements for Cdc48-dependent disassembly of the CMG helicase in budding yeast

  Mukherjee, P. & Labib, K., 10 Sept 2019, In: Cell Reports. 28, 11, p. 2777-2783.e4 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cullin Proteins 100%
  • Saccharomycetales 83%
  • Ligases 74%
  • Ubiquitin 68%
  • Cofactor 62%
  15 Citations (Scopus)

  75 Downloads (Pure)

• Pif1-family helicases support fork convergence during DNA replication termination in eukaryotes

  Deegan, T., Baxter, J., Ortiz Bazan, M., Yeeles, J. T. P. & Labib, K., 18 Apr 2019, In: Molecular Cell. 74, 2, p. 231-244.e9 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Eukaryota 100%
  • DNA Replication 96%
  • Type II DNA Topoisomerase 94%
  • DNA Helicases 33%
  • DNA 27%
  44 Citations (Scopus)

  160 Downloads (Pure)

• TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

  Sonneville, R., Bhowmick, R., Hoffmann, S., Mailand, N., Hickson, I. D. & Labib, K., 23 Sept 2019, In: eLife. 8, p. 1-19 19 p., e48686.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Replication 100%
  • Mitosis 98%
  • DNA Repair 92%
  • Error 74%
  • Genome 33%
  47 Citations (Scopus)

  86 Downloads (Pure)
• 2018

  Histone H2A-H2B binding by Pol α in the eukaryotic replisome contributes to the maintenance of repressive chromatin

  Evrin, C., Maman, J., Diamante, A., Pellegrini, L. & Labib, K., 1 Oct 2018, In: EMBO Journal. 37, 19, p. 1-16 16 p., e99021.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Histone 100%
  • Histones 87%
  • Chromatin 82%
  • Maintenance 65%
  • Mutation 39%
  39 Citations (Scopus)

  173 Downloads (Pure)

• LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

  Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In: Nature Communications. 9, p. 1-11 11 p., 728.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lunar Module 100%
  • Aurora 86%
  • nuclease 85%
  • mitosis 76%
  • chromatin 71%
  28 Citations (Scopus)

  224 Downloads (Pure)

• The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

  Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In: PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 3'-nucleotidase 100%
  • Recombinational DNA Repair 71%
  • chromosome segregation 68%
  • Chromosome Segregation 68%
  • Caenorhabditis elegans 60%
  14 Citations (Scopus)

  191 Downloads (Pure)

• The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

  Gan, H., Serra-Cardona, A., Hua, X., Zhou, H., Labib, K., Yu, C. & Zhang, Z., 4 Oct 2018, In: Molecular Cell. 72, 1, p. 140-151.e3 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Histones 100%
  • Nucleosomes 75%
  • Epigenomics 55%
  • DNA 47%
  • DNA Primase 32%
  92 Citations (Scopus)

  165 Downloads (Pure)
• 2017

  Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design

  Wu, Y., Villa, F., Maman, J., Lau, Y. H., Dobnikar, L., Simon, A. C., Labib, K., Spring, D. R. & Pellegrini, L., 9 Oct 2017, In: Angewandte Chemie International Edition. 56, p. 12866-12872 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peptides 100%
  • Genomic Instability 83%
  • Genomics 79%
  • Peptide 44%
  • Synthetic Lethal Mutations 37%
  18 Citations (Scopus)

  293 Downloads (Pure)

• Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

  Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In: Cell Reports. 18, 13, p. 3033-3042 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitination 100%
  • Lysine 87%
  • Mutation 78%
  • Chromosomes 72%
  • DNA Helicases 42%
  29 Citations (Scopus)

  221 Downloads (Pure)
• 2016

  Chromosome Duplication in Saccharomyces cerevisiae

  Bell, S. P. & Labib, K., 6 Jul 2016, In: Genetics. 203, 3, p. 1027-1067 41 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chromosome Duplication 100%
  • DNA Replication 67%
  • DNA Helicases 46%
  • Chromatids 42%
  • Replication Origin 42%
  225 Citations (Scopus)

  219 Downloads (Pure)

• Ctf4 is a hub in the eukaryotic replisome that links multiple CIP-box proteins to the CMG helicase

  Villa, F., Simon, A. C., Ortiz Bazan, M. A., Kilkenny, M. L., Wirthensohn, D., Wightman, M., Matak-Vinkovíc, D., Pellegrini, L. & Labib, K., 4 Aug 2016, In: Molecular Cell. 63, 3, p. 385-396 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribosomal DNA 100%
  • ACTH (7-38) 58%
  • DNA Helicases 39%
  • Chromosomes, Human, Pair 12 37%
  • DNA-Directed DNA Polymerase 31%
  83 Citations (Scopus)

  295 Downloads (Pure)

• MINDY-1 is a member of an evolutionarily conserved and structurally distinct new family of Deubiquitinating enzymes

  Rehman, S. A. A., Kristariyanto, Y., Choi, S. Y., Nkosi, P., Weidlich, S., Labib, K., Hofmann, K. & Kulathu, Y., 7 Jul 2016, In: Molecular Cell. 63, p. 146-155 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Deubiquitinating Enzymes 100%
  • Ubiquitin 72%
  • Proteostasis 23%
  • Catalysis 21%
  • Ubiquitination 19%
  238 Citations (Scopus)

  214 Downloads (Pure)

• The replisome-coupled E3 ubiquitin ligase Rtt101Mms22 counteracts Mrc1 function to tolerate genotoxic stress

  Buser, R., Kellner, V., Melnik, A., Wilson-Zbinden, C., Schellhaas, R., Kastner, L., Piwko, W., Dees, M., Picotti, P., Maric, M., Labib, K., Luke, B. & Peter, M., 5 Feb 2016, In: PLoS Genetics. 12, 2, 25 p., e1005843.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • ubiquitin-protein ligase 100%
  • Ubiquitin-Protein Ligases 89%
  • DNA replication 82%
  • DNA Replication 79%
  • ligases 76%
  25 Citations (Scopus)

  446 Downloads (Pure)
• 2015

  A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

  García-Rodríguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D. & Labib, K., 15 Oct 2015, In: Nucleic Acids Research. 43, 18, p. 8830-8838

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • S Phase Cell Cycle Checkpoints 100%
  • Saccharomycetales 77%
  • DNA Polymerase II 33%
  • Phosphotransferases 33%
  • Mutation 23%
  42 Citations (Scopus)

  163 Downloads (Pure)

• Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C.elegans Embryos

  Sonneville, R., Craig, G., Labib, K., Gartner, A. & Blow, J. J., 21 Jul 2015, In: Cell Reports. 12, 3, p. 405-417 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Replication 100%
  • Chromatin 88%
  • Embryonic Structures 81%
  • condensin complexes 79%
  • Chromosomes 78%
  24 Citations (Scopus)

  232 Downloads (Pure)

• Tethering of SCF^Dia2 to the replisome promotes efficient ubiquitylation and disassembly of the CMG helicase

  Maculins, T., Nkosi, P. J., Nishikawa, H. & Labib, K., 31 Aug 2015, In: Current Biology. 25, 17, p. 2254-2259 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • tetratricopeptide repeats 100%
  • F-box proteins 90%
  • Ubiquitination 69%
  • Tetratricopeptide Repeat 64%
  • DNA helicases 47%
  33 Citations (Scopus)

  166 Downloads (Pure)
• 2014

  A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

  Simon, A. C., Zhou, J. C., Perera, R. L., van Deursen, F., Evrin, C., Ivanova, M. E., Kilkenny, M. L., Renault, L., Kjaer, S., Matak-Vinković, D., Labib, K., Costa, A. & Pellegrini, L., 4 May 2014, In: Nature. 510, 7504, p. 293-297 5 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase 100%
  • Eukaryota 61%
  • DNA Helicases 41%
  • X Ray Crystallography 40%
  • Fungal Proteins 37%
  151 Citations (Scopus)

• Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

  Maric, M., Maculins, T., De Piccoli, G. & Labib, K., 24 Oct 2014, In: Science. 346, 6208, 13 p., 1253596.

  Research output: Contribution to journal › Article › peer-review

  • Ligases 100%
  • Ubiquitin 91%
  • DNA Replication 91%
  • Chromosomes 72%
  • DNA Helicases 31%
  157 Citations (Scopus)