Genetic Structural and Chemical Validation of Aspergillus Fumigatus Cell Wall Targets (Programme Grant)

van Aalten, Daan (Investigator)

Gene Regulation and Expression

Project Details

Status	Finished
Effective start/end date	1/11/14 → 31/10/19

Funding

Medical Research Council (MR/M004139/1): £1,751,714.00

Research Output

11 Article

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Fang, W., Sanz, A. B., Galan Bartual, S., Wang, B., Ferenbach, A., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D., 10 Apr 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 1669.

Research output: Contribution to journal › Article

Open Access

File

83 Downloads (Pure)

Evidence for substrate assisted catalysis in N-acetylphosphoglucosamine mutase

Raimi, O. G., Hurtado Guerrero, R. & van Aalten, D. M. F., 16 Aug 2018, In : The Biochemical journal. 475, 15, p. 2547-2557 11 p.

Research output: Contribution to journal › Article

Open Access

File

97 Downloads (Pure)

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

Raich, L., Borodkin, V., Fang, W., Castro-Lopez, J., van Aalten, D. M. F., Hurtado-Guerrero, R. & Rovira, C., 16 Mar 2016, In : Journal of the American Chemical Society. 138, 10, p. 3325-3332 8 p.

Research output: Contribution to journal › Article

25 Citations (Scopus)