Genetic Structural and Chemical Validation of Aspergillus Fumigatus Cell Wall Targets (Programme Grant)

Research Output

2020

Targeting a critical step in fungal hexosamine biosynthesis

Lockhart, D., Stanley, M., Raimi, O., Robinson, D., Boldovjakova, D., Squair, D., Ferenbach, A., Fang, W. & van Aalten, D., 27 Apr 2020, In : Journal of Biological Chemistry.

Research output: Contribution to journalArticle

2019

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Fang, W., Sanz, A. B., Galan Bartual, S., Wang, B., Ferenbach, A., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D., 10 Apr 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 1669.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
95 Downloads (Pure)
2018

Evidence for substrate assisted catalysis in N-acetylphosphoglucosamine mutase

Raimi, O. G., Hurtado Guerrero, R. & van Aalten, D. M. F., 16 Aug 2018, In : The Biochemical journal. 475, 15, p. 2547-2557 11 p.

Research output: Contribution to journalArticle

Open Access
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107 Downloads (Pure)
2016

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations

Raich, L., Borodkin, V., Fang, W., Castro-Lopez, J., van Aalten, D. M. F., Hurtado-Guerrero, R. & Rovira, C., 16 Mar 2016, In : Journal of the American Chemical Society. 138, 10, p. 3325-3332 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2015

Evidence for a functional O-linked N-acetylglucosamine (O-GlcNAc) system in the thermophilic bacterium Thermobaculum terrenum

Ostrowski, A., Gundogdu, M., Ferenbach, A. T., Lebedev, A. A. & Van Aalten, D. M. F., 18 Dec 2015, In : Journal of Biological Chemistry. 290, 51, p. 30291-30305 15 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP-4-dehydrorhamnose reductases (RmlD)

van der Beek, S. L., Le Breton, Y., Ferenbach, A. T., Chapman, R. N., van Aalten, D. M. F., Hopkins Navratilova, I., Boons, G. J., Mciver, K. S., van Sorge, N. M. & Dorfmueller, H., 24 Nov 2015, In : Molecular Microbiology. 98, 5, p. 946-962 16 p.

Research output: Contribution to journalArticle

Open Access
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18 Citations (Scopus)
225 Downloads (Pure)

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E. A., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. & van Aalten, D. M. F., 19 Jun 2015, In : ACS Chemical Biology. 10, 6, p. 1425-1434 10 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

The early metazoan Trichoplax adhaerens possesses a functional O-GlcNAc system

Selvan, N., Mariappa, D., van den Toorn, H. W. P., Heck, A. J. R., Ferenbach, A. T. & van Aalten, D. M. F., 8 May 2015, In : Journal of Biological Chemistry. p. 11969-11982 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos

Jank, T., Eckerle, S., Steinemann, M., Trillhaase, C., Schimpl, M., Wiese, S., Van Aalten, D. M. F., Driever, W. & Aktories, K., 20 Jul 2015, In : Nature Communications. 6, 16 p., 7807.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)
2014

A structural and biochemical model of processive chitin synthesis

Dorfmueller, H. C., Ferenbach, A. T., Borodkin, V. S. & van Aalten, D. M. F., 15 Aug 2014, In : Journal of Biological Chemistry. 289, p. 23020-23028 9 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
164 Downloads (Pure)
Open Access
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31 Citations (Scopus)
86 Downloads (Pure)

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

Lockhart, D. E. A., Schuettelkopf, A., Blair, D. E. & van Aalten, D. M. F., 25 Aug 2014, In : FEBS Letters. 588, 17, p. 3282-3290 9 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
118 Downloads (Pure)