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Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network
Alessi, Dario
(Investigator)
MRC PPU
Overview
Research Outputs
(3)
Project Details
Status
Active
Effective start/end date
1/08/19
→
14/01/23
Funding
(17298):
£374,265.00
View all
View less
Research output
Research output per year
2020
2021
3
Article
Research output per year
Research output per year
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U.
,
Karapetsas, A.
,
Nirujogi, R. S.
, Mathea, S., Chatterjee, D.,
Pal, P.
,
Lis, P.
,
Taylor, M.
,
Purlyte, E.
, Gourlay, R., Dorward, M., Weidlich, S.,
Toth, R.
, Polinski, N. K., Knapp, S.,
Tonelli, F.
&
Alessi, D.
,
10 Feb 2021
,
In:
Biochemical Journal.
478
,
3
,
p. 553-578
26 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Phosphorylation
Proteins
Osteoclasts
Mutation
Phospho-Specific Antibodies
10
Downloads (Pure)
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M.
&
Alessi, D.
,
Apr 2020
,
In:
Current Opinion in Cell Biology.
63
,
p. 102-113
12 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
leucine-rich repeat proteins
Protein Kinases
Parkinson Disease
alpha-Synuclein
Protein Kinase Inhibitors
16
Citations (Scopus)
157
Downloads (Pure)
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Kalogeropulou, A. F.
,
Freemantle, J. B.
,
Lis, P.
, Vides, E. G., Polinski, N. K. &
Alessi, D. R.
,
27 Nov 2020
,
In:
Biochemical Journal.
477
,
22
,
p. 4397-4423
27 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Phosphorylation
Nigericin
Monensin
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Gene encoding
1
Citation (Scopus)
15
Downloads (Pure)