Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

Alessi, Dario (Investigator)

MRC PPU

Project Details

Status	Active
Effective start/end date	1/08/19 → 14/01/23

Funding

(17298): £374,265.00

3 Article

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., Lis, P., Taylor, M., Purlyte, E., Gourlay, R., Dorward, M., Weidlich, S., Toth, R., Polinski, N. K., Knapp, S., Tonelli, F. & Alessi, D., 10 Feb 2021, In: Biochemical Journal. 478, 3, p. 553-578 26 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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10 Downloads (Pure)
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M. & Alessi, D., Apr 2020, In: Current Opinion in Cell Biology. 63, p. 102-113 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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16 Citations (Scopus)

157 Downloads (Pure)
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Kalogeropulou, A. F., Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K. & Alessi, D. R., 27 Nov 2020, In: Biochemical Journal. 477, 22, p. 4397-4423 27 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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1 Citation (Scopus)

15 Downloads (Pure)