Research output per year
Research output per year
Research output
- 8 Article
Search results
-
2022
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R. & Pfeffer, S. R., 23 Sept 2022, In: eLife. 11, 29 p., e79771.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)18 Downloads (Pure) -
2021
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., Lis, P., Taylor, M., Purlyte, E., Gourlay, R., Dorward, M., Weidlich, S., Toth, R., Polinski, N. K., Knapp, S., Tonelli, F. & Alessi, D., 10 Feb 2021, In: Biochemical Journal. 478, 3, p. 553-578 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)115 Downloads (Pure) -
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
Nirujogi, R. S., Tonelli, F., Taylor, M., Lis, P., Zimprich, A., Sammler, E. & Alessi, D. R., 22 Jan 2021, In: Biochemical Journal. 478, 2, p. 299-326 28 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)135 Downloads (Pure) -
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Khan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R. & Pfeffer, S. R., 27 Oct 2021, In: eLife. 10, 26 p., e67900.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)44 Downloads (Pure) -
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Waschbüsch, D., Berndsen, K., Lis, P., Knebel, A., Lam, Y. P. Y., Alessi, D. R. & Khan, A. R., 4 Nov 2021, In: EMBO Reports. 22, 11, 22 p., e52675.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)117 Downloads (Pure) -
2020
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M. & Alessi, D., Apr 2020, In: Current Opinion in Cell Biology. 63, p. 102-113 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Citations (Scopus)194 Downloads (Pure) -
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Kalogeropulou, A. F., Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K. & Alessi, D. R., 27 Nov 2020, In: Biochemical Journal. 477, 22, p. 4397-4423 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)87 Downloads (Pure) -
2019
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D., 12 Nov 2019, In: eLife. 8, 37 p., e50416.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)104 Downloads (Pure)