Research output per year
Research output per year
Research output
- 8 Article
Search results
-
2022
A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
Vides, E. G., Adhikari, A., Chiang, C. Y., Lis, P., Purlyte, E., Limouse, C., Shumate, J. L., Spínola-Lasso, E., Dhekne, H. S., Alessi, D. R. & Pfeffer, S. R., 23 Sept 2022, In: eLife. 11, 29 p., e79771.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)117 Downloads (Pure) -
2021
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Malik, A. U., Karapetsas, A., Nirujogi, R. S., Mathea, S., Chatterjee, D., Pal, P., Lis, P., Taylor, M., Purlyte, E., Gourlay, R., Dorward, M., Weidlich, S., Toth, R., Polinski, N. K., Knapp, S., Tonelli, F. (Lead / Corresponding author) & Alessi, D. (Lead / Corresponding author), 10 Feb 2021, In: Biochemical Journal. 478, 3, p. 553-578 26 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)258 Downloads (Pure) -
Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites
Nirujogi, R. S. (Lead / Corresponding author), Tonelli, F., Taylor, M., Lis, P., Zimprich, A., Sammler, E. & Alessi, D. R. (Lead / Corresponding author), 22 Jan 2021, In: Biochemical Journal. 478, 2, p. 299-326 28 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)249 Downloads (Pure) -
Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
Khan, S. S., Sobu, Y., Dhekne, H. S., Tonelli, F., Berndsen, K., Alessi, D. R. & Pfeffer, S. R. (Lead / Corresponding author), 27 Oct 2021, In: eLife. 10, 26 p., e67900.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)142 Downloads (Pure) -
Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
Waschbüsch, D., Berndsen, K., Lis, P., Knebel, A., Lam, Y. P. Y., Alessi, D. R. (Lead / Corresponding author) & Khan, A. R. (Lead / Corresponding author), 4 Nov 2021, In: EMBO Reports. 22, 11, 22 p., e52675.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)277 Downloads (Pure) -
2020
Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Taylor, M. & Alessi, D. (Lead / Corresponding author), Apr 2020, In: Current Opinion in Cell Biology. 63, p. 102-113 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Citations (Scopus)292 Downloads (Pure) -
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Kalogeropulou, A. F. (Lead / Corresponding author), Freemantle, J. B., Lis, P., Vides, E. G., Polinski, N. K. & Alessi, D. R. (Lead / Corresponding author), 27 Nov 2020, In: Biochemical Journal. 477, 22, p. 4397-4423 27 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile41 Citations (Scopus)170 Downloads (Pure) -
2019
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Berndsen, K., Lis, P., Yeshaw, W. M., Wawro, P. S., Nirujogi, R., Wightman, M., Macartney, T., Dorward, M., Knebel, A., Tonelli, F., Pfeffer, S. R. & Alessi, D. (Lead / Corresponding author), 12 Nov 2019, In: eLife. 8, 37 p., e50416.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Citations (Scopus)199 Downloads (Pure)