How Does O-GlcNAc Transferase Integrate Glucose and Glutamine Metabolism to Control Cytotoxic T Lymphocyte Function?

Project Details

StatusFinished
Effective start/end date1/01/1630/06/17

Funding

  • Wellcome Trust (097418/Z/11/A): £124,244.00

Research Output

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
  • 10 Citations (Scopus)
    92 Downloads (Pure)

    Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

    Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 13 Citations (Scopus)
    199 Downloads (Pure)

    Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

    Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 100 Citations (Scopus)
    145 Downloads (Pure)