How Does O-GlcNAc Transferase Integrate Glucose and Glutamine Metabolism to Control Cytotoxic T Lymphocyte Function?

Research Output

2019

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
104 Downloads (Pure)
2018

Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In : Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

Research output: Contribution to journalArticle

Open Access
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14 Citations (Scopus)
209 Downloads (Pure)
2016

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In : Nature Immunology. 17, 6, p. 712-720 9 p.

Research output: Contribution to journalArticle

Open Access
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105 Citations (Scopus)
157 Downloads (Pure)

The cytotoxic T cell proteome and its shaping by the kinase mTOR

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In : Nature Immunology. 17, 1, p. 104-112 9 p.

Research output: Contribution to journalArticle

Open Access
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82 Citations (Scopus)
202 Downloads (Pure)
2015

ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M., 17 Feb 2015, In : Immunity. 42, 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 11 May 2015, In : Nature Medicine. 21, 6, p. 591-600 10 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

Signaling in lymphocyte activation

Cantrell, D., Jun 2015, In : Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A., 4 Aug 2015, In : EMBO Journal. 34, 15, p. 2008-2024 17 p.

Research output: Contribution to journalArticle

Open Access
56 Citations (Scopus)
2014

Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sep 2014, In : PLoS ONE. 9, 9, 7 p., e106710.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
152 Downloads (Pure)

Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8+ T cells

Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A., 21 Oct 2014, In : Science Signaling. 7, 348, 12 p., ra99.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A., Dec 2014, In : Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

Research output: Contribution to journalArticle

Open Access
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13 Citations (Scopus)
146 Downloads (Pure)

Serine-threonine kinases in TCR signaling

Navarro, M. N. & Cantrell, D. A., Sep 2014, In : Nature Immunology. 15, 9, p. 808-814 7 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2013

AMPKα1: a glucose sensor that controls CD8 T-cell memory

Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In : European Journal of Immunology. 43, 4, p. 889-896 8 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A., May 2013, In : Nature Immunology. 14, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

336 Citations (Scopus)

LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In : PLoS ONE. 8, 3, 9 p., e60217.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

Schweighoffer, E., Vanes, L., Nys, J., Cantrell, D., McCleary, S., Smithers, N. & Tybulewicz, V. L. J., 21 Mar 2013, In : Immunity. 38, 3, p. 475-488 14 p.

Research output: Contribution to journalArticle

Open Access
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110 Citations (Scopus)
83 Downloads (Pure)

The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In : PLoS ONE. 8, 10, 16 p., e77537.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2012

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A., 17 Dec 2012, In : Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

Research output: Contribution to journalArticle

Open Access
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282 Citations (Scopus)
334 Downloads (Pure)

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A., 15 Mar 2012, In : Biochemical Journal. 442, 3, p. 649-659 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)