How Does O-GlcNAc Transferase Integrate Glucose and Glutamine Metabolism to Control Cytotoxic T Lymphocyte Function?

Research output

Research output per year 2012 2012 2013 2014 2015 2022

• 22 Article

Research output per year

Research output per year

Search results

• 2022

  Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects

  Marques, C. A., Ridgway, M., Tinti, M., Cassidy, A. & Horn, D., 10 Sept 2022, In: Nature Communications. 13, 16 p., 5326.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma brucei brucei 100%
  • genome 99%
  • progressions 86%
  • Cytometry 80%
  • RNA Interference 73%
  16 Downloads (Pure)
• 2020

  Single Cell Glucose Uptake Assays: A Cautionary Tale

  Sinclair, L. V., Barthelemy, C. & Cantrell, D. A., 17 Aug 2020, In: Immunometabolism. 2, 4, 13 p., e200029.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose 100%
  • Facilitative Glucose Transport Proteins 41%
  • Glucose 35%
  • T-Lymphocytes 30%
  • Deoxyglucose 8%
  78 Downloads (Pure)
• 2019

  Antigen receptor control of methionine metabolism in T cells

  Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In: eLife. 8, p. 1-29 29 p., e44210.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Antigen Receptors 100%
  • Methionine 83%
  • Antigen 67%
  • Pharmacological Metabolism 62%
  • T-Lymphocytes 49%
  80 Citations (Scopus)

  126 Downloads (Pure)
• 2018

  Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs

  Rollings, C., Sinclair, L., Brady, H. J. M., Cantrell, D. & Ross, S., 17 Apr 2018, In: Science Signaling. 11, 526, p. 1-16 16 p., eaap8112.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tofacitinib 100%
  • Effector 96%
  • Proteome 92%
  • Interleukin-2 78%
  • Shape 57%
  36 Citations (Scopus)

  239 Downloads (Pure)
• 2016

  Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

  Swamy, M., Pathak, S., Grzes, K. M., Damerow, S., Sinclair, L. V., van Aalten, D. M. F. & Cantrell, D. A., Jun 2016, In: Nature Immunology. 17, 6, p. 712-720 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cell Self Renewal 100%
  • Glutamine 84%
  • Glucose 50%
  • T-Lymphocytes 49%
  • Glycosyltransferases 45%
  214 Citations (Scopus)

  178 Downloads (Pure)

• The cytotoxic T cell proteome and its shaping by the kinase mTOR

  Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Brenes Murillo, A., Hawkins, P. T., Stephens, L. R., Lamond, A. I. & Cantrell, D. A., Jan 2016, In: Nature Immunology. 17, 1, p. 104-112 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cytotoxic T-Lymphocytes 100%
  • Mechanistic Target of Rapamycin Complex 1 97%
  • Proteome 96%
  • Phosphotransferases 71%
  • phosphatidylinositol 3,4,5-triphosphate 67%
  141 Citations (Scopus)

  276 Downloads (Pure)
• 2015

  ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation

  Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C-Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. & Hedrick, S. M., 17 Feb 2015, In: Immunity. 42, 2, p. 239-251 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Helper-Inducer T-Lymphocytes 100%
  • Cell Differentiation 78%
  • Transcription Factors 72%
  • Germinal Center 32%
  • Immunoglobulin Isotypes 16%
  154 Citations (Scopus)

• Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells

  Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. & Maini, M. K., 11 May 2015, In: Nature Medicine. 21, 6, p. 591-600 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Stellate Crystal 100%
  • Myeloid-Derived Suppressor Cells 82%
  • L-Arginine 78%
  • Nutrient 65%
  • Hepatitis B 59%
  187 Citations (Scopus)

• Signaling in lymphocyte activation

  Cantrell, D., Jun 2015, In: Cold spring harbor perspectives in biology. 7, 6, 14 p., a018788.

  Research output: Contribution to journal › Article › peer-review

  • Inositol 100%
  • Lymphocyte Activation 89%
  • Lipid 58%
  • Lipids 55%
  • B-Cell Antigen Receptors 53%
  55 Citations (Scopus)

• Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes

  Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A., 4 Aug 2015, In: EMBO Journal. 34, 15, p. 2008-2024 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antigen Receptors 100%
  • Interleukin-2 71%
  • Antigen 67%
  • Strength 50%
  • T-Lymphocytes 49%
  97 Citations (Scopus)
• 2014

  Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells

  Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., 2 Sept 2014, In: PLoS ONE. 9, 9, 7 p., e106710.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenine Nucleotides 100%
  • Metformin 86%
  • Protein Kinases 73%
  • T-Lymphocytes 49%
  • Adenosine Monophosphate 44%
  28 Citations (Scopus)

  168 Downloads (Pure)

• Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naïve CD8⁺ T cells

  Navarro, M. N., Feijoo-Carnero, C., Gonzalez Arandilla, A., Trost, M. & Cantrell, D. A., 21 Oct 2014, In: Science Signaling. 7, 348, 12 p., ra99.

  Research output: Contribution to journal › Article › peer-review

  • protein kinase D2 100%
  • Diglycerides 61%
  • T-Cell Antigen Receptor 52%
  • T-Lymphocytes 31%
  • Protein 21%
  26 Citations (Scopus)

• Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks

  Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A., Dec 2014, In: Molecular & Cellular Proteomics. 13, 12, p. 3544-3557 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • protein kinase D 100%
  • protein kinase D2 87%
  • T-Lymphocytes 39%
  • Protein 26%
  • Proteins 19%
  15 Citations (Scopus)

  169 Downloads (Pure)

• Serine-threonine kinases in TCR signaling

  Navarro, M. N. & Cantrell, D. A., Sept 2014, In: Nature Immunology. 15, 9, p. 808-814 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Protein-Serine-Threonine Kinases 100%
  • T-Lymphocytes 55%
  • T-Cell Antigen Receptor 30%
  • Signal Transduction 23%
  54 Citations (Scopus)
• 2013

  AMPKα1: a glucose sensor that controls CD8 T-cell memory

  Rolf, J., Zarrouk, M., Finlay, D. K., Foretz, M., Viollet, B. & Cantrell, D. A., Apr 2013, In: European Journal of Immunology. 43, 4, p. 889-896 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxic T-Lymphocytes 100%
  • Glucose 87%
  • T-Lymphocytes 86%
  • Adenosine Monophosphate 77%
  • Protein Kinases 64%
  172 Citations (Scopus)

• Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

  Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y-B., Taylor, P. M. & Cantrell, D. A., May 2013, In: Nature Immunology. 14, 5, p. 500-508 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Antigen Receptors 100%
  • Cell Differentiation 65%
  • Neutral Amino Acids 58%
  • Amino Acids 56%
  • T-Lymphocytes 49%
  548 Citations (Scopus)

• LKB1 Mediates the Development of Conventional and Innate T Cells via AMP-Dependent Kinase Autonomous Pathways

  Zarrouk, M., Rolf, J. & Cantrell, D. A., 22 Mar 2013, In: PLoS ONE. 8, 3, 9 p., e60217.

  Research output: Contribution to journal › Article › peer-review

  • Adenylate Kinase 100%
  • Thymocytes 79%
  • AMP-Activated Protein Kinases 65%
  • T-Lymphocytes 45%
  • Antigen Receptors, T-Cell, alpha-beta 25%
  16 Citations (Scopus)

• The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway

  Schweighoffer, E., Vanes, L., Nys, J., Cantrell, D., McCleary, S., Smithers, N. & Tybulewicz, V. L. J., 21 Mar 2013, In: Immunity. 38, 3, p. 475-488 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • B-Cell Activation Factor Receptor 100%
  • B-Cell Antigen Receptors 76%
  • Signal Transduction 46%
  • B-Lymphocytes 46%
  • Immunoglobulin Subunits 16%
  150 Citations (Scopus)

  96 Downloads (Pure)

• The impact of KLF2 modulation on the transcriptional program and function of CD8 T Cells

  Preston, G. C., Feijoo-Carnero, C., Schurch, N., Cowling, V. H. & Cantrell, D. A., 2013, In: PLoS ONE. 8, 10, 16 p., e77537.

  Research output: Contribution to journal › Article › peer-review

  • T-Lymphocytes 100%
  • Down-Regulation 42%
  • Ligands 28%
  • Antigen Receptors 25%
  • Proto-Oncogene Proteins c-akt 24%
  23 Citations (Scopus)
• 2012

  PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8 T cells

  Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K. & Cantrell, D. A., 17 Dec 2012, In: Journal of Experimental Medicine. 209, 13, p. 2441-2453 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hypoxia-Inducible Factor 1 100%
  • Mechanistic Target of Rapamycin Complex 1 99%
  • TOR Serine-Threonine Kinases 88%
  • T-Lymphocytes 48%
  • Phosphatidylinositol 3-Kinase 45%
  407 Citations (Scopus)

  371 Downloads (Pure)

• Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

  Navarro, M. N., Sinclair, L. V., Feijoo-Carnero, C., Clarke, R., Matthews, S. A. & Cantrell, D. A., 15 Mar 2012, In: Biochemical Journal. 442, 3, p. 649-659 11 p.

  Research output: Contribution to journal › Article › peer-review

  • protein kinase D2 100%
  • T-Cell Antigen Receptor 52%
  • Antigen 42%
  • T-Lymphocytes 31%
  • Protein 21%
  18 Citations (Scopus)

• Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

  Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In: European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

  Research output: Contribution to journal › Article › peer-review

  • protein kinase D 100%
  • Lymphoid Tissue 68%
  • Integrins 59%
  • Protein Isoforms 51%
  • Lymphocytes 43%
  11 Citations (Scopus)