Keyphrases
Aryl Aldehydes
100%
In Vitro Assessment
100%
Benzofuran-3(2H)-one
100%
Trypanosoma Cruzi (T. cruzi)
100%
Bioactivation
100%
Antileishmanial Activity
100%
Chagas Disease
100%
5-Nitroimidazoles
100%
Leishmania Donovani
75%
Axenic Amastigotes
75%
Malic Enzyme
66%
Mode of Action
58%
4-Nitroimidazole
50%
Cytotoxicity
50%
Nitroreductase
50%
Antichagasic Drug
33%
Drug Discovery
33%
Causative Agents
33%
Pharmacophore
33%
Reduced Susceptibility
33%
Epimastigote
33%
Thermal Proteome Profiling
33%
Chymotrypsin
33%
Protease Inhibitors
33%
Overexpression
33%
Genetic Engineering
33%
Phenotypic Screening
33%
Enzyme Inhibition
33%
Superior Activity
25%
Peritoneal Mouse
25%
Benzofuranone Derivative
25%
Hydroxylamine
25%
Leishmania Parasites
25%
IC50 Value
25%
L. Major
25%
IC50
25%
Leishmania Major
25%
Methoxy
25%
Mouse Macrophages
25%
High Selectivity
25%
THP1
25%
Monocytic Cells
25%
Human Leukemia
25%
Promastigote
25%
Nitroso
25%
Selectivity Index
25%
1-Methyl
25%
Pharmacology, Toxicology and Pharmaceutical Science
Chagas Disease
100%
Proteasome
100%
4 Nitroimidazole
100%
Bioactivation
100%
Malate Dehydrogenase (Decarboxylating)
66%
Amastigote
60%
Nitroreductase
40%
IC50
40%
Cytotoxicity
40%
Trypanosoma Cruzi
33%
Chymotrypsin
33%
Proteasome Inhibitor
33%
Enzyme Inhibition
33%
Drug Discovery
33%
Epimastigote
33%
Proteome
33%
3 Benzofuranone Derivative
20%
2 Methyl 5 Nitroimidazole
20%
Monocytic Leukemia
20%
Hydroxylamine
20%
Promastigote
20%
Leishmania Major
20%
Leishmania
20%