Identifying Novel Opportunities for Translational Research, Precision Medicine and Drug Repurposing in Cardiovascular Disease using Pharmacoepidemiology, Genetic Epidemiology and Bioinformatics

2023

Amino acid homeostasis is a target of metformin therapy

Forteath, C., Mordi, I., Nisr, R., Gutierrez-Lara, E. J., Alqurashi, N., Phair, I. R., Cameron, A. R., Beall, C., Nisr, I., Mohan, M., Wong, A. K. F., Dihoum, A., Mohammad, A., Palmer, C. N. A., Lamont, D., Sakamoto, K., Viollet, B., Foretz, M., Lang, C. C. (Lead / Corresponding author) & Rena, G. (Lead / Corresponding author), Aug 2023, In: Molecular Metabolism. 74, 16 p., 101750.

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3 Citations (Scopus)

118 Downloads (Pure)

2022

Prediction of Major Adverse Cardiovascular Events from Retinal, Clinical and Genomic Data in Individuals with Type 2 Diabetes: A Population Cohort Study

Mordi, I. R. (Lead / Corresponding author), Trucco, E., Syed, M. G., MacGillivray, T., Nar, A., Huang, Y., George, G., Hogg, S., Venkateshan, R., Prathiba, V., Anjana, R. M., Mohan, V., Palmer, C. N. A., Pearson, E. R., Lang, C. C., Doney, A. S. F. (Lead / Corresponding author) & INSPIRED Investigators, 1 Mar 2022, In: Diabetes Care. 45, 3, p. 710-716 7 p.

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23 Citations (Scopus)

283 Downloads (Pure)

2021

Heart failure treatment up‐titration and outcome and age: an analysis of BIOSTAT‐CHF

Mordi, I. R., Ouwerkerk, W., Anker, S. D., Cleland, J. G., Dickstein, K., Metra, M., Ng, L. L., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. A. & Lang, C. C. (Lead / Corresponding author), Mar 2021, In: European Journal of Heart Failure. 23, 3, p. 436-444 9 p.

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31 Citations (Scopus)

150 Downloads (Pure)

Type 2 Diabetes, Metabolic traits and Risk of Heart Failure: a Mendelian Randomization study

Mordi, I. (Lead / Corresponding author), Lumbers, R. T., Palmer, C. N. A., Pearson, E. R., Sattar, N., Holmes, M. V., Lang, C. C. & HERMES Consortium, 1 Jul 2021, In: Diabetes Care. 44, 7, p. 1699-1705 7 p.

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19 Citations (Scopus)

161 Downloads (Pure)

2020

Biomarkers of Aortopathy in Marfan Syndrome

Iskandar, Z., Mordi, I., Lang, C., Huang, J. & Choy, A., 1 Mar 2020, In: Cardiology in Review. 28, 2, p. 92-97 6 p.

Research output: Contribution to journal › Review article › peer-review

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10 Citations (Scopus)

358 Downloads (Pure)

Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, M., Choy, A. M. J., Gandy, S., George, J., Khan, F., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C. (Lead / Corresponding author), 1 Jun 2020, In: Diabetes Care. 43, 6, p. 1356-1359 4 p.

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129 Citations (Scopus)

225 Downloads (Pure)

Genetic and pharmacological relationship between P-Glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An Epidemiological and Genomic Population-Based Cohort Study in Scotland, UK

Mordi, I. R. (Lead / Corresponding author), Chan, B., Yanez, N. D., Palmer, C. N. A., Lang, C. C. & Chalmers, J. D. (Lead / Corresponding author), 23 Nov 2020, In: PLoS Medicine. 17, 11, 16 p., e1003372.

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4 Citations (Scopus)

86 Downloads (Pure)

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Regeneron Genetics Center, Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D. & Biggs, M. L. & 32 others, Bloom, H. L., Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T. (Lead / Corresponding author), 9 Jan 2020, In: Nature Communications. 11, 12 p., 163.

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560 Citations (Scopus)

265 Downloads (Pure)

Letter by Mordi et al Regarding Article, "Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial"

Mordi, I. R., Mohan, M. & Lang, C. C., 28 Jan 2020, In: Circulation. 141, 4, p. e55-e56 2 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

Microvascular Disease with Heart Failure with Reduced and Preserved Ejection Fraction in Patients with Type 2 Diabetes

Mordi, I. (Lead / Corresponding author), Tee, A., Palmer, C., McCrimmon, R., Doney, A. & Lang, C., 1 Jun 2020, In: ESC Heart Failure. 7, 3, p. 1168-1177 10 p.

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15 Citations (Scopus)

110 Downloads (Pure)

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

Cao, T. H. (Lead / Corresponding author), Jones, D. J. L., Voors, A. A., Quinn, P. A., Sandhu, J. K., Chan, D. C. S., Parry, H., Mohan, P., Mordi, I., Sama, I. E., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J. & Zannad, F. & 2 others, Lang, C. & Ng, L. L. (Lead / Corresponding author), Jan 2020, In: European Journal of Heart Failure. 22, 1, p. 70-80 11 p.

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33 Citations (Scopus)

133 Downloads (Pure)

Renal and Cardiovascular Effects of SGLT2 inhibition in combination with loop Diuretics in patients with Type 2 Diabetes and Chronic Heart Failure: The RECEDE-CHF Trial

Mordi, N. A., Mordi, I. R., Singh, J. S., McCrimmon, R. J., Struthers, A. D. & Lang, C. C. (Lead / Corresponding author), 3 Nov 2020, In: Circulation. 142, 18, p. 1713-1724 12 p.

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185 Citations (Scopus)

260 Downloads (Pure)

2019

A randomized controlled trial of metformin on left ventricular hypertrophy in patients with coronary artery disease without diabetes: the MET-REMODEL trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. .., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C. (Lead / Corresponding author), 1 Nov 2019, In: European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journal › Article › peer-review

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113 Citations (Scopus)

287 Downloads (Pure)

Association of Chromosome 9p21 with Subsequent Coronary Heart Disease events: A GENIUS-CHD study of individual participant data

CARDIoGRAMplusC4D Consortium, Patel, R. S. (Lead / Corresponding author), Schmidt, A. F., Tragante, V., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Dubé, M. P., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H. & Boeckx, B. & 31 others, Braund, P. S., Breitling, L. P., Delgado, G., Duarte, N. E., Dufresne, L., Eriksson, N., Foco, L., Gijsberts, C. M., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kuukasjärvi, P., Lee, V. V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L. P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y. V., Tanck, M. W. T., Mordi, I. R., Palmer, C. N. & Lang, C. C., Apr 2019, In: Circulation: Genomic and Precision Medicine. 12, 4, p. 161-172 12 p.

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27 Citations (Scopus)

146 Downloads (Pure)

Differential Association of Genetic Risk of Coronary Artery Disease with Development of Heart Failure with Reduced Versus Preserved Ejection Fraction: A GoDARTS Mendelian Randomization Study and Meta-Analysis

Mordi, I. R. (Lead / Corresponding author), Pearson, E. R., Palmer, C. N. A., Doney, A. S. F. & Lang, C. C., 12 Feb 2019, In: Circulation. 139, 7, p. 986-988 3 p.

Research output: Contribution to journal › Letter › peer-review

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8 Citations (Scopus)

104 Downloads (Pure)

Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis

Trenkwalder, T., Nelson, C. P., Musameh, M. D., Mordi, I. R., Kessler, T., Pellegrini, C., Debiec, R., Rheude, T., Lazovic, V., Zeng, L., Martinsson, A., Gustav Smith, J., Gådin, J. R., Franco-Cereceda, A., Eriksson, P., Nielsen, J. B., Graham, S. E., Willer, C. J., Hveem, K. & Kastrati, A. & 9 others, Braund, P. S., Palmer, C. N. A., Aracil, A., Husser, O., Koenig, W., Schunkert, H., Lang, C. C. (Lead / Corresponding author), Hengstenberg, C. (Lead / Corresponding author) & Samani, N. J. (Lead / Corresponding author), 1 Feb 2019, In: International Journal of Cardiology. 276, p. 212-217 6 p.

Research output: Contribution to journal › Article › peer-review

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12 Citations (Scopus)

190 Downloads (Pure)

Exercise-based cardiac rehabilitation for adults with heart failure

Long, L., Mordi, I. R., Bridges, C., Sagar, V. A., Davies, E. J., Coats, A. J. S., Dalal, H., Rees, K., Singh, S. J. & Taylor, R. S., 29 Jan 2019, In: Cochrane Database of Systematic Reviews. 2019, 1, 184 p., CD003331.

Research output: Contribution to journal › Review article › peer-review

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351 Citations (Scopus)

280 Downloads (Pure)

Heart failure in the outpatient versus inpatient setting: findings from the BIOSTAT-CHF study

Ferreira, J. P., Metra, M., Mordi, I., Gregson, J., ter Maaten, J., Tromp, J., Anker, S. D., Dickstein, K., Hillege, H. L., Ng, L. L., van Veldhuisen, D. J., Lang, C. C., Voors, A. A. & Zannad, F. (Lead / Corresponding author), 1 Jan 2019, In: European Journal of Heart Failure. 21, 1, p. 112-120 9 p.

Research output: Contribution to journal › Article › peer-review

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50 Citations (Scopus)

152 Downloads (Pure)

Non-Invasive Imaging in Diabetic Cardiomyopathy

Mordi, I. R. (Lead / Corresponding author), 16 Apr 2019, In: Journal of Cardiovascular Development and Disease. 6, 2, p. 1-11 11 p., 18.

Research output: Contribution to journal › Review article › peer-review

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14 Citations (Scopus)

159 Downloads (Pure)

Plasma Desmosine and Abdominal Aortic Aneurysm Disease

Mordi, I., Forsythe, R., Gellatly, C., Iskandar, Z., McBride, O., Saratzis, A., Chalmers, R., Chin, C. W. L., Bown, M. J., Newby, D. E., Lang, C., Huang, J. (Lead / Corresponding author) & Choy, A. (Lead / Corresponding author), 15 Oct 2019, In: Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease (JAHA). 8, 20, 9 p., e013743.

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30 Citations (Scopus)

167 Downloads (Pure)

Prognostic Significance of Changes in Heart Rate Following Uptitration of Beta-Blockers in Patients with Sub-Optimally Treated Heart Failure with Reduced Ejection Fraction in Sinus Rhythm versus Atrial Fibrillation

Mordi, I. (Lead / Corresponding author), Santema, B. T., Kloosterman, M., Choy, A.-M., Rienstra, M., Van Gelder, I. C., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H. & Zannad, F. & 2 others, Voors, A. A. & Lang, C., Jul 2019, In: Clinical Research in Cardiology . 108, 7, p. 797-805 9 p.

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10 Citations (Scopus)

249 Downloads (Pure)

Proprotein convertase subtilisin/kexin 9 inhibitors in reducing cardiovascular outcomes: A systematic review and meta-analysis

Du, H., Li, X., Su, N., Li, L., Hao, X., Gao, H., Kwong, J. S. W., Vandvik, P. O., Yang, X., Nemeth, I., Mordi, I., Li, Q., Zhang, L., Rao, L., Lang, C., Li, J., Tian, H. & Li, S. (Lead / Corresponding author), Aug 2019, In: Heart. 105, 15, p. 1149-1159 11 p.

Research output: Contribution to journal › Article › peer-review

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30 Citations (Scopus)

709 Downloads (Pure)

Subsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium

Patel, R. (Lead / Corresponding author), Tragante, V., Schmidt, A. F., McCubrey, R. O., Holmes, M. V., Howe, L. J., Direk, K., Åkerblom, A., Leander, K., Virani, S. S., Kaminski, K. A., Muehlschlegel, J. D., Allayee, H., Almgren, P., Alver, M., Baranova, E. V., Behlouli, H., Boeckx, B., Braund, P. S. & Breitling, L. P. & 161 others, Delgado, G., Duarte, N. E., Dubé, M.-P., Dufresne, L., Eriksson, N., Foco, L., Scholz, M., Gijsberts, C. M., Glinge, C., Gong, Y., Hartiala, J., Heydarpour, M., Hubacek, J. A., Kleber, M., Kofink, D., Kotti, S., Kuukasjärvi, P., Lee, V.-V., Leiherer, A., Lenzini, P. A., Levin, D., Lyytikäinen, L.-P., Martinelli, N., Mons, U., Nelson, C. P., Nikus, K., Pilbrow, A. P., Ploski, R., Sun, Y. V., Tanck, M. W. T., Tang, W. H. W., Trompet, S., van der Laan, S. W., Van Setten, J., Vilmundarson, R. O., Viviani Anselmi, C., Vlachopoulou, E., Al Ali, L., Boerwinkle, E., Briguori, C., Carlquist, J. F., Carruthers, K. F., Casu, G., Deanfield, J., Deloukas, P., Dudbridge, F., Engström, T., Fitzpatrick, N., Fox, K., Gigante, B., James, S., Lokki, M.-L., Lotufo, P. A., Marziliano, N., Mordi, I. R., Muhlestein, J. B., Newton-Cheh, C., Pitha, J., Saely, C. H., Samman-Tahhan, A., Sandesara, P. B., Teren, A., Timmis, A., Van de Werf, F., Wauters, E., Wilde, A. A. M., Ford, I., Stott, D. J., Algra, A., Andreassi, M. G., Ardissino, D., Arsenault, B. J., Ballantyne, C. M., Bergmeijer, T. O., Bezzina, C. R., Body, S. C., Boersma, E. H., Bogaty, P., Bots, M., Brenner, H., Brugts, J. J., Burkhardt, R., Carpeggiani, C., Condorelli, G., Cooper-DeHoff, R. M., Cresci, S., Danchin, N., de Faire, U., Doughty, R. N., Drexel, H., Engert, J. C., Fox, K. A. A., Girelli, D., Grobbee, D. E., Hagström, E., Hazen, S. L., Held, C., Hemingway, H., Hoefer, I. E., Hovingh, G. K., Jabbari, R., Johnson, J. A., Jukema, J. W., Kaczor, M. P., Kähönen, M., Kettner, J., Kiliszek, M., Klungel, O. H., Lagerqvist, B., Lambrechts, D., Laurikka, J. O., Lehtimäki, T., Lindholm, D., Mahmoodi, B. K., Maitland-van der Zee, A. H., McPherson, R., Melander, O., Metspalu, A., Niemcunowicz-Janica, A., Olivieri, O., Opolski, G., Palmer, C. N., Pasterkamp, G., Pepine, C. J., Pereira, A. C., Pilote, L., Quyyumi, A. A., Richards, A. M., Sanak, M., Siegbahn, A., Simon, T., Sinisalo, J., Smith, J. G., Spertus, J. A., Stender, S., Stewart, A. F. R., Szczeklik, W., Szpakowicz, A., Tardif, J.-C., Ten Berg, J. M., Tfelt-Hansen, J., Thanassoulis, G., Thiery, J., Torp-Pedersen, C., van der Graaf, Y., Visseren, F. L. J., Waltenberger, J., Weeke, P. E., Van der Harst, P., Lang, C. C., Sattar, N., Cameron, V. A., Anderson, J. L., Brophy, J. M., Paré, G., Horne, B. D., März, W., Wallentin, L., Samani, N. J., Hingorani, A. D. & Asselbergs, F. W. (Lead / Corresponding author), Apr 2019, In: Circulation: Genomic and Precision Medicine. 12, 4, p. 145-160 16 p., e002470.

Research output: Contribution to journal › Article › peer-review

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21 Citations (Scopus)

278 Downloads (Pure)

2018

British Cardiovascular Society Young Investigator Award: finalists 2018

Greenwood, J. P. (Lead / Corresponding author), Edgar, L., Kaier, T., Mordi, I. & Raphael, C., Oct 2018, In: Heart (British Cardiac Society). 104, 19, p. 1637-1638 2 p.

Research output: Contribution to journal › Special issue › peer-review

Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction

Santema, B. T., Kloosterman, M., Van Gelder, I. C., Mordi, I., Lang, C., Lam, C. S. P., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G. S., van der Harst, P., Hillege, H. L., ter Maaten, J. M., Metra, M., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H. & Zannad, F. & 4 others, Damman, K., van der Meer, P., Rienstra, M. & Voors, A. A. (Lead / Corresponding author), 14 Nov 2018, In: European Heart Journal. 39, 43, p. 3867-3875 9 p.

Research output: Contribution to journal › Article › peer-review

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52 Citations (Scopus)

133 Downloads (Pure)

Comprehensive Echocardiographic and Cardiovascular Magnetic Resonance Evaluation Differentiates Between Patients with Heart Failure with Preserved Ejection Fraction, Hypertensive Patients and Healthy Controls

Mordi, I. R., Singh, S., Rudd, A., Srinivasan, J., Frenneaux, M. P., Tzemos, N. & Dawson, D. K. (Lead / Corresponding author), Apr 2018, In: JACC. Cardiovascular Imaging. 11, 4, p. 577-585 9 p.

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95 Citations (Scopus)

250 Downloads (Pure)

Epicardial Adipose Tissue Is Related to Arterial Stiffness and Inflammation in Patients with Cardiovascular Disease and Type 2 Diabetes

Al-Talabany, S., Mordi, I. (Lead / Corresponding author), Houston, J. G., Colhoun, H. M., Weir-McCall, J. R., Matthew, S. Z., Looker, H. C., Levin, D., Belch, J. J. F., Dove, F., Khan, F. & Lang, C. C., 13 Feb 2018, In: BMC Cardiovascular Disorders. 18, p. 1-8 8 p., 31.

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37 Citations (Scopus)

198 Downloads (Pure)

Iron Therapy in Heart Failure: Ready for Primetime?

Mordi, I., Tee, A. & Lang, C. (Lead / Corresponding author), 6 May 2018, In: Cardiac Failure Review. 4, 1, p. 28-32 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

The Authors Reply

Mordi, I. R. (Lead / Corresponding author) & Dawson, D. K., Jul 2018, In: JACC: Cardiovascular Imaging. 11, 7, p. 1039-1040 2 p.

Research output: Contribution to journal › Letter › peer-review

2017

Efficacy of noninvasive cardiac imaging tests in diagnosis and management of stable coronary artery disease

Mordi, I. R. (Lead / Corresponding author), Badar, A. A., Irving, R. J., Weir-McCall, J. R., Houston, J. G. & Lang, C. C., 21 Nov 2017, In: Vascular Health and Risk Management. 13, p. 427-437 11 p.

Research output: Contribution to journal › Review article › peer-review

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34 Citations (Scopus)

342 Downloads (Pure)

Late Gadolinium Enhancement and the Risk for Ventricular Arrhythmias or Sudden Death in Dilated Cardiomyopathy: Systematic Review and Meta-Analysis

Di Marco, A., Anguera, I., Schmitt, M., Klem, I., Neilan, T., White, J. A., Sramko, M., Masci, P. G., Barison, A., Mckenna, P., Mordi, I., Haugaa, K. H., Leyva, F., Rodriguez Capitán, J., Satoh, H., Nabeta, T., Dallaglio, P. D., Campbell, N. G., Sabaté, X. & Cequier, Á., Jan 2017, In: JACC: Heart Failure. 5, 1, p. 28-38 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

350 Citations (Scopus)

Renal and Cardiovascular Effects of sodium–glucose cotransporter 2 (SGLT2) inhibition in combination with loop Diuretics in diabetic patients with Chronic Heart Failure (RECEDE-CHF): protocol for a randomised controlled double-blind cross-over trial

Mordi, N. A. (Lead / Corresponding author), Mordi, I. R., Singh, J. S., Baig, F., Choy, A.-M., McCrimmon, R. J., Struthers, A. D. & Lang, C. C., 1 Oct 2017, In: BMJ Open. 7, 10, p. 1-10 10 p., e018097.

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36 Citations (Scopus)

284 Downloads (Pure)

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

Steggall, A., Mordi, I. & Lang, C. (Lead / Corresponding author), 10 May 2017, In: Diseases. 5, 2, p. 1-18 18 p., 14.

Research output: Contribution to journal › Review article › peer-review

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Identifying Novel Opportunities for Translational Research, Precision Medicine and Drug Repurposing in Cardiovascular Disease using Pharmacoepidemiology, Genetic Epidemiology and Bioinformatics

Research output

Search results