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Keyphrases
Degrader
63%
Ternary Complex
50%
Small Molecules
41%
Gram-negative Bacteria
31%
Efflux
31%
Efflux Pump
31%
Structural Modification
31%
Drug Efflux
31%
Pentamidine
31%
Cardioprotection
31%
Phosphoinositide 3-kinase (PI3K)
31%
Trypanosoma Brucei
31%
SOCS1
31%
Druggability
31%
Protein Degrader
31%
Molecular Drive
31%
PARP Inhibitor Resistance
31%
Resistance Mechanism
31%
Proximity Binding
31%
Active Pharmaceutical Ingredients
31%
Binding Assay
31%
Complex Analysis
31%
Family Proteins
31%
Neural Regeneration
31%
Targeted Protein
31%
Molecular Mechanism
31%
Clinical Practice
31%
Niraparib
31%
Proteolysis Targeting chimera (PROTAC)
31%
Partially Disordered
31%
Bromodomain-containing Protein 4 (BRD4)
29%
Ubiquitination
28%
ATP Binding Cassette Subfamily G Member 2 (ABCG2)
25%
P-glycoprotein (P-gp)
25%
Escherichia Coli
21%
TolC
21%
Aquaporin
21%
Cell Behavior
21%
Drug Design
21%
Olaparib
19%
ATP Binding Cassette Subfamily B Member 1 (ABCB1)
19%
Paclitaxel
19%
Small-molecule Degrader
18%
Lysine
15%
E3 Ubiquitin Ligase
15%
Fast Sampling
15%
Solubility-diffusion Model
15%
Permeator
15%
PARP Inhibitors (PARPi)
12%
Efflux Transporters
12%
Heterologous Expression
12%
Substrate Specificity
12%
Efflux Assay
12%
Therapeutic Potential
12%
RING E3 Ligase
12%
Gram-negative
10%
Bioactivity
10%
Molecular Features
10%
Molecular Determinants
10%
LpxC
10%
New Drugs
10%
Chemical Groups
10%
Efflux System
10%
HyPer
10%
Low Permeability
10%
Gram-negative Cell Envelope
10%
Physicochemical Features
10%
Rapid Development
10%
Decision Stages
10%
Binary Interactions
10%
Ternary Interaction
10%
Mechanistic Steps
10%
In Vitro Assay
10%
Drug Efflux Pumps
10%
Mode of Action
10%
Cellular Performance
10%
Protein Degradation
10%
Cell Permeability
10%
Multidrug-resistant Infections
10%
Rational Optimization
10%
Molecular Glue
10%
Rational Design
10%
Chemical Moieties
10%
Ubiquitin-proteasome System
10%
Bona Fide
10%
Target Engagement
10%
Ubiquitin-like Protein
10%
3D Strain
10%
E3 Ligase
9%
Targeted Protein Degradation
9%
PI3K Isoforms
9%
PI3K Signaling Pathway
9%
Protein Family
9%
Ubiquitin
7%
Cullin2
7%
Ubiquitinome
7%
In Vitro Ubiquitination Assay
7%
Cryo-EM Structure
7%
Rational Drug Design
7%
Cell Degradation
7%
Nucleophilic Attack
7%
Mass Spectrometry
7%
Optimal Positioning
7%
CRL2
7%
Targeted Degradation
7%
Enhanced Efficacy
7%
Long-lived
7%
Resistance Biomarkers
6%
Adaptive Drug Resistance
6%
Carboplatin/paclitaxel
6%
RNA Sequencing (RNA-seq)
6%
Transcriptional Regulation
6%
Western Blot
6%
Ovarian Cancer Patients
6%
Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS)
6%
Via Resistance
6%
Paclitaxel Chemotherapy
6%
SiRNA Knockdown
6%
Patient-derived Cell Line
6%
Clinically Significant
6%
ABCB1 Expression
6%
Proteomic Analysis
6%
Transporter Expression
6%
Drug Resistance
6%
MS-based Proteomics
6%
Quantitative PCR
6%
First-line Chemotherapy
6%
Drug Transporters
6%
A2780 Cells
6%
Chemotherapy Regimen
6%
Maintenance Treatment
6%
Polarized Cells
6%
Chemosensitivity
6%
MTT Assay
6%
Clonogenic Assay
6%
Background Maintenance
6%
Dicationic
5%
Drug Permeation
5%
Specific mutation
5%
Wide-ranging
5%
Pore Size
5%
Gene Family
5%
Antitrypanosomal Activity
5%
Ionic Species
5%
Conserved Motif
5%
Molecular Dynamics
5%
Cross-resistance
5%
Aquaporin-2 (AQP2)
5%
Melarsoprol
5%
Diamidines
5%
Permeant
5%
Common Ancestor
5%
Amino Acids
5%
Membrane Potential
5%
Interaction Kinetics
5%
Pathogenic Proteins
5%
Automated Workflow
5%
ARV-825
5%
DNA Scaffold
5%
Sensorgram
5%
Sample Quantity
5%
Spatial Proximity
5%
Substrate Receptor
5%
Substrate Binding
5%
Von Hippel-Lindau
5%
Drug pipeline
5%
Enzymatic Degradation
5%
Binding Kinetics
5%
Fluorescence Quenching
5%
Simultaneous Measurement
5%
Single Run
5%
Cereblon
5%
BRD3
5%
BRD2
5%
Single-molecule Fluorescence Resonance Energy Transfer (smFRET)
5%
Ternary Complex Formation
5%
Y-DNA
5%
Combined Analysis
5%
Bromodomain
5%
Biochemistry, Genetics and Molecular Biology
Ubiquitination
100%
Ternary Complex
71%
Drug Development
70%
Small Molecule
54%
Molecular Glue
53%
Protein Catabolism
46%
Ubiquitin-Conjugating Enzyme
42%
Ubiquitin
39%
Gram Negative Bacterium
31%
Trypanosoma Brucei
31%
Aquaporin
31%
Drug Activity
31%
Cytokine
31%
Protein Family
31%
Proteasome
31%
Cell Membrane Permeability
31%
Molecular Mechanism
31%
Estrogen Receptor Alpha
31%
Ubiquitin Ligase
27%
Signaling Protein
18%
Lysine
15%
Complex Formation
15%
Cryoelectron Microscopy
13%
Biological Activity
10%
Drug Uptake
10%
Minimum Inhibitory Concentration
10%
Fluorescence Energy Transfer
10%
Binding Kinetics
10%
Quenching (Fluorescence)
10%
Enzymatic Degradation
10%
Bromodomain
10%
Cereblon
10%
BRD4
10%
BRD2
10%
BRDT
10%
Cooperation
10%
Estrogen Receptor
10%
Cullin
7%
Amino Acids
7%
Pore Size
7%
Multigene Family
7%
Membrane Potential
7%
Melarsoprol
7%
Mass Spectrometry
7%
Nucleophilicity
7%
Protein Complexes
5%
Pharmacology, Toxicology and Pharmaceutical Science
Gram Negative Bacterium
63%
Antimicrobial Agent
53%
Effusion
47%
Drug Development
45%
Antibiotics
42%
Phosphotransferase Activator
31%
Immune Dysregulation
31%
Phosphotransferase
31%
Reperfusion Injury
31%
Malignant Neoplasm
31%
Growth Factor
31%
Nerve Crush
31%
Nicotinamide Adenine Dinucleotide Adenosine Diphosphate Ribosyltransferase Inhibitor
31%
ABCG2
31%
Lipid
31%
Pentamidine
31%
Trypanosoma Brucei
31%
Enzymes
31%
Aquaporin
21%
Niraparib
19%
Porin
15%
Antiinfective Agent
15%
Paclitaxel
15%
Liposome
15%
High-Throughput Screening
15%
Olaparib
11%
Bacterial Infection
10%
Chemotherapy Regimens
7%
Substrate Specificity
7%
Drug Resistance
7%
Escherichia coli
7%
Amino Acid
5%
Melarsoprol
5%
Antitrypanosomal
5%