Keyphrases
Gram-negative Bacteria
100%
Gram-negative
53%
Antibiotics
53%
Efflux
40%
Permeation Rate
40%
Neuroregeneration
40%
Fast Prediction
40%
Efflux Pump
40%
Active Compounds
40%
Molecular Substructure
40%
Structural Modification
40%
Drug Efflux
40%
Target Molecule
40%
Degrader
40%
Brownian Dynamics
40%
Small Molecules
40%
Pentamidine
40%
Cardioprotection
40%
Phosphoinositide 3-kinase (PI3K)
40%
Membrane Channels
40%
Drug Action
40%
Trypanosoma Brucei
40%
Ubiquitination
30%
Escherichia Coli
26%
TolC
26%
Aquaporin
26%
Bioactivity
26%
Molecular Features
26%
Multidrug-resistant Infection
26%
Temperature Acceleration
20%
Antibacterial Action
20%
Molecular Transformation
20%
Acceleration Schemes
20%
Permeator
20%
Approximate Estimation
20%
Molecular Permeability
20%
Accumulation Assay
20%
All-atom
20%
Antibiotic Accumulation
20%
Fast Sampling
20%
Lysine
20%
Ubiquitin
20%
Diffusion Model
20%
Swelling Test
20%
High-throughput Screening
20%
Overall Process
20%
Bacterial Membrane
20%
Accumulation Rate
20%
Dynamic Approach
20%
Porin Channel
20%
Liposomes
20%
Effective Antibiotics
20%
Computational Approach
20%
Drug Development
19%
Therapeutic Potential
15%
Molecular Determinants
13%
LpxC
13%
Drug Design
13%
New Drugs
13%
Chemical Groups
13%
Efflux System
13%
HyPer
13%
Low Permeability
13%
Drug Efflux Pump
13%
Negative Permeability
13%
Matched Molecular Pair Analysis
13%
Gram-negative Cell Envelope
13%
Physicochemical Features
13%
Rapid Development
13%
New Antibiotics
13%
Complex Cell
13%
Chemical Space
13%
Compound Classes
13%
Machine Learning
13%
Chemical Features
13%
Effective Treatment
13%
Resistant Species
13%
Broad-spectrum Antibiotics
13%
Cell Envelope
13%
World Health Organization
13%
Data-driven Approach
13%
Concentration Data
13%
Recurring
13%
Drug Uptake
13%
Gram-positive
13%
Antibiotic Drugs
13%
Minimum Inhibitory Concentration
13%
PI3K Isoforms
11%
PI3K Signaling Pathway
11%
RING E3 Ligase
10%
Small Molecule Degrader
10%
Therapeutic Efficacy
10%
Long-lived
10%
Cullin2
10%
Ubiquitinome
10%
In Vitro Ubiquitination Assay
10%
Cryo-EM Structure
10%
Cullin-RING E3 Ligase
10%
Protein Ubiquitination
10%
Rational Drug Design
10%
Optimal Position
10%
Cell Degradation
10%
Ternary Complex
10%
Impact Target
10%
Nucleophilic Attack
10%
Targeted Degradation
10%
Mass Spectrometry
10%
Proteolysis Targeting chimera (PROTAC)
10%
Dicationic
6%
Drug Permeation
6%
Specific mutation
6%
Wide-ranging
6%
Pore Size
6%
Gene Family
6%
Antitrypanosomal Activity
6%
Ionic Species
6%
Conserved Motif
6%
Molecular Dynamics
6%
Cross-resistance
6%
Aquaporin-2 (AQP2)
6%
Melarsoprol
6%
Diamidines
6%
Permeant
6%
Common Ancestor
6%
Amino Acids
6%
Membrane Potential
6%
Nerve Crush
5%
Local Administration
5%
Tissue Regeneration
5%
Beneficial Effects
5%
Nerve Regeneration
5%
Multiple Proteins
5%
Kinase Activators
5%
Protein Kinase
5%
Small Molecule Activation
5%
Tissue Protection
5%
Global Conformational Changes
5%
Lipid Kinase
5%
Neurite Outgrowth
5%
Catalytic Cycle
5%
Multiple Steps
5%
Acute Treatment
5%
Isoform Protein
5%
Kinase Signaling
5%
Overactivation
5%
Rodent Models
5%
Therapeutic Benefits
5%
Cellular Response
5%
Ischemia-reperfusion Injury
5%
Chemical Tools
5%
Rodents
5%
Growth Factor Signaling
5%
Distinct Mechanism
5%
PI3K Signaling
5%
Human Cells
5%
Immune Dysregulation
5%
Biochemistry, Genetics and Molecular Biology
Gram Negative Bacterium
80%
Small Molecule
48%
Trypanosoma Brucei
40%
Nerve Regeneration
40%
Aquaporin
40%
Drug Activity
40%
Ubiquitination
40%
Signal Transduction
40%
Isoform
40%
Kinase
40%
Phosphotransferase
40%
Escherichia coli
26%
Biological Activity
26%
Conformational Change
20%
Growth Factor
20%
Reperfusion
20%
Enzyme
20%
Rodent Cell
20%
Lipid
20%
Neurite Outgrowth
20%
Immunity
20%
Ligase
16%
Ubiquitin
16%
Cullin
16%
Lysine
16%
Wild Type
13%
Drug Uptake
13%
Minimum Inhibitory Concentration
13%
Amino Acids
10%
Pore Size
10%
Multigene Family
10%
Membrane Potential
10%
Dynamics
10%
Melarsoprol
10%
Mass Spectrometry
8%
Nucleophilicity
8%
Ternary Complex
8%
Cryoelectron Microscopy
8%