Industrial Collaborative Awards in Science and Engineering (iCASE) Studentships for the University of Dundee

Research output

Research output per year 2020 2020 2022 2023 2024 2024

• 5 Article

Research output per year

Research output per year

Search results

• 2024

  Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance

  Gurvic, D. (Lead / Corresponding author) & Zachariae, U. (Lead / Corresponding author), 16 Mar 2024, In: npj Antimicrobials and Resistance . 2, 11 p., 6.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gram-negative Bacteria 100%
  • Efflux 100%
  • Efflux Pump 100%
  • Drug Efflux 100%
  • Active Compounds 100%
  5 Downloads (Pure)
• 2023

  A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

  Gong, G. Q., Bilanges, B., Allsop, B., Masson, G. R., Roberton, V., Askwith, T., Oxenford, S., Madsen, R. R., Conduit, S. E., Bellini, D., Fitzek, M., Collier, M., Najam, O., He, Z., Wahab, B., McLaughlin, S. H., Chan, A. W. E., Feierberg, I., Madin, A. & Morelli, D. & 21 others, Bhamra, A., Vinciauskaite, V., Anderson, K. E., Surinova, S., Pinotsis, N., Lopez-Guadamillas, E., Wilcox, M., Hooper, A., Patel, C., Whitehead, M. A., Bunney, T. D., Stephens, L. R., Hawkins, P. T., Katan, M., Yellon, D. M., Davidson, S. M., Smith, D. M., Phillips, J. B., Angell, R., Williams, R. L. & Vanhaesebroeck, B. (Lead / Corresponding author), 1 Jun 2023, In: Nature. 618, p. 159-168 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Signal Transduction 100%
  • Small Molecule 100%
  • Phosphotransferase 100%
  • Kinase 100%
  • Isoform 100%
  27 Citations (Scopus)

  186 Downloads (Pure)

• Fast prediction of antibiotic permeability through membrane channels using Brownian dynamics

  Acharya, A., Jana, K., Gurvic, D., Zachariae, U. & Kleinekathöfer, U. (Lead / Corresponding author), 25 Jul 2023, In: Biophysical Journal. 122, 14, p. 2996-3007 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brownian Dynamics 100%
  • Antibiotics 100%
  • Membrane Channels 100%
  • Permeation Rate 100%
  • Fast Prediction 100%
  2 Citations (Scopus)

  34 Downloads (Pure)
• 2022

  Data-driven derivation of molecular substructures that enhance drug activity in Gram-negative bacteria

  Gurvic, D., Leach, A. G. & Zachariae, U. (Lead / Corresponding author), 28 Apr 2022, In: Journal of Medicinal Chemistry. 65, 8, p. 6088-6099 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gram-negative Bacteria 100%
  • Gram-negative 100%
  • Drug Action 100%
  • Molecular Substructure 100%
  • Gram-Negative Bacteria 100%
  8 Citations (Scopus)

  143 Downloads (Pure)
• 2020

  Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

  Alghamdi, A. H., Munday, J. C., Campagnaro, G. D., Gurvic, D., Svensson, F., Okpara, C. E., Kumar, A., Quintana, J. F., Abril, M. E. M., Milić, P., Watson, L., Paape, D., Settimo, L., Dimitriou, A., Wielinska, J., Smart, G., Anderson, L. F., Woodley, C. M., Kelley, S. P. Y. & Ibrahim, H. M. S. & 12 others, Hulpia, F., Al-Salabi, M. I., Eze, A. A., Gudin, S., Field, M., Dardonville, C., Tidwell, R. R. .., Carrington, M., O'Neill, P. M., Boykin, D. W. .., Zachariae, U. & de Koning, H. P. (Lead / Corresponding author), 4 Sept 2020, In: eLife. 9, 33 p., e56416.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Trypanosoma Brucei 100%
  • Pentamidine 100%
  • Aquaporin 100%
  • Dynamics 25%
  • Amino Acids 25%
  17 Citations (Scopus)

  136 Downloads (Pure)