Research output per year
Research output per year
Search results
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2026
Identification of novel drug-specific PARP inhibitor resistance mechanisms in ovarian cancer–implications for clinical practice
Macdonald, C. J., Mcwhirter, A., Vaidyanathan, A., Ferguson, M. J., Eberl, H. C., Stronach, E. A., Sawers, L. & Smith, G. (Lead / Corresponding author), 17 Apr 2026, In: British Journal of Cancer. 135, p. 290-302Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC
Verhoef, C. J. A., Crowe, C., Nakasone, M., De La Cuadra Baste, A., Harzing, T., Span, N. A. S., Sathe, G., Demmers, L. C., Iso, K., Ottmann, C., Brunsveld, L., Ciulli, A. (Lead / Corresponding author) & Cossar, P. J. (Lead / Corresponding author), 15 Jul 2026, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open Access -
Proximity Binding Assay for PROTAC Ternary Complex Analysis
Ponzo, I., Soldà, A., Crowe, C., Dahl, G., Jahodová, T., Heerwig, A., Geschwindner, S., Ciulli, A. (Lead / Corresponding author) & Rant, U. (Lead / Corresponding author), 22 May 2026, In: ACS Sensors. 11, 5, p. 3876-3888 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
2024
Mechanism of degrader-targeted protein ubiquitinability
Crowe, C., Nakasone, M., Chandler, S., Craigon, C., Sathe, G., Tatham, M., Makukhin, N., Hay, R. & Ciulli, A. (Lead / Corresponding author), 11 Oct 2024, In: Science Advances. 10, 41, 21 p., eado6492.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Link opens in a new tab Citations (Scopus)206 Downloads (Pure) -
Multidrug efflux in Gram-negative bacteria: structural modifications in active compounds leading to efflux pump avoidance
Gurvic, D. (Lead / Corresponding author) & Zachariae, U. (Lead / Corresponding author), 16 Mar 2024, In: npj Antimicrobials and Resistance . 2, 11 p., 6.Research output: Contribution to journal › Article › peer-review
Open AccessFile118 Downloads (Pure) -
2023
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration
Gong, G. Q., Bilanges, B., Allsop, B., Masson, G. R., Roberton, V., Askwith, T., Oxenford, S., Madsen, R. R., Conduit, S. E., Bellini, D., Fitzek, M., Collier, M., Najam, O., He, Z., Wahab, B., McLaughlin, S. H., Chan, A. W. E., Feierberg, I., Madin, A. & Morelli, D. & 21 others, , 1 Jun 2023, In: Nature. 618, p. 159-168 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Link opens in a new tab Citations (Scopus)527 Downloads (Pure) -
Fast prediction of antibiotic permeability through membrane channels using Brownian dynamics
Acharya, A., Jana, K., Gurvic, D., Zachariae, U. & Kleinekathöfer, U. (Lead / Corresponding author), 25 Jul 2023, In: Biophysical Journal. 122, 14, p. 2996-3007 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Link opens in a new tab Citations (Scopus)126 Downloads (Pure) -
2022
Data-driven derivation of molecular substructures that enhance drug activity in Gram-negative bacteria
Gurvic, D., Leach, A. G. & Zachariae, U. (Lead / Corresponding author), 28 Apr 2022, In: Journal of Medicinal Chemistry. 65, 8, p. 6088-6099 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Link opens in a new tab Citations (Scopus)313 Downloads (Pure) -
2020
Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei
Alghamdi, A. H., Munday, J. C., Campagnaro, G. D., Gurvic, D., Svensson, F., Okpara, C. E., Kumar, A., Quintana, J. F., Abril, M. E. M., Milić, P., Watson, L., Paape, D., Settimo, L., Dimitriou, A., Wielinska, J., Smart, G., Anderson, L. F., Woodley, C. M., Kelley, S. P. Y. & Ibrahim, H. M. S. & 12 others, , 4 Sept 2020, In: eLife. 9, 33 p., e56416.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Link opens in a new tab Citations (Scopus)205 Downloads (Pure)