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Inhibition by Proxy Targeting Fungal Citin Synthesis through Sugar Nucleotide Biosynthesis (Clinical Postdoctoral Research Training Fellowship)
Lockhart, Deborah
(Investigator)
van Aalten, Daan
(Investigator)
Gene Regulation and Expression
Overview
Fingerprint
Research Outputs
(3)
Project Details
Status
Finished
Effective start/end date
1/12/15
→
31/05/18
Funding
Wellcome Trust
(105772/Z/14/Z):
£208,270.02
View all
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Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Cell Wall
Medicine & Life Sciences
100%
Aspergillus fumigatus
Medicine & Life Sciences
73%
phosphomannomutase
Medicine & Life Sciences
57%
Hexosamine
Chemical Compounds
46%
Hexosamines
Medicine & Life Sciences
46%
Chitin
Medicine & Life Sciences
36%
Biosynthesis
Chemical Compounds
27%
Glucans
Medicine & Life Sciences
25%
Research output
Research output per year
2020
2020
2021
2021
3
Article
Research output per year
Research output per year
Genetic and structural validation of phosphomannomutase as a cell wall target in Aspergillus fumigatus
Zhang, Y.
,
Fang, W.
,
Raimi, O. G.
,
Lockhart, D.
,
Ferenbach, A. T.
,
Lu, L.
&
van Aalten, D.
,
Jul 2021
,
In:
Molecular Microbiology.
116
,
1
,
p. 245-259
15 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
phosphomannomutase
100%
Aspergillus fumigatus
69%
Cell Wall
57%
galactomannan
41%
mannose 1-phosphate guanylyltransferase
28%
1
Citation (Scopus)
41
Downloads (Pure)
The citron homology domain as a scaffold for Rho1 signaling
Bartual, S. G.
,
Wei, W.
,
Zhou, Y.
,
Pravata, V. M.
,
Fang, W.
,
Yan, K.
,
Ferenbach, A. T.
,
Lockhart, D. E. A.
&
van Aalten, D. M. F.
,
28 Sep 2021
,
In:
Proceedings of the National Academy of Sciences of the United States of America.
118
,
39
,
10 p.
, e2110298118.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Cell Wall
100%
Chitin
43%
Glucans
43%
Guanine Nucleotide Exchange Factors
43%
Aspergillus fumigatus
40%
19
Downloads (Pure)
Targeting a critical step in fungal hexosamine biosynthesis
Lockhart, D.
,
Stanley, M.
,
Raimi, O.
,
Robinson, D.
,
Boldovjakova, D.
,
Squair, D.
,
Ferenbach, A.
,
Fang, W.
&
van Aalten, D.
,
26 Jun 2020
,
In:
Journal of Biological Chemistry.
295
,
26
,
p. 8678-8691
14 p.
Research output
:
Contribution to journal
›
Article
›
peer-review
Open Access
File
Hexosamine
100%
Hexosamines
99%
Cell Wall
71%
Biosynthesis
58%
Aspergillus fumigatus
43%
4
Citations (Scopus)
33
Downloads (Pure)