Research output per year
Research output per year
- 26 results
Search results
-
2024
CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection
Lukoszek, R., Inesta-Vaquera, F., Brett, N. J. .. M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W. & Cowling, V. H. (Lead / Corresponding author), 23 Jul 2024, In: Cell Reports. 43, 7, 20 p., 114405.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)71 Downloads (Pure) -
2022
CMTR1 is recruited to transcription start sites and promotes ribosomal protein and histone gene expression in embryonic stem cells
Liang, S., Clara Silva, J., Suska, O., Lukoszek, R., Almohammed, R. & Cowling, V. H. (Lead / Corresponding author), 21 Mar 2022, In: Nucleic Acids Research. 50, 5, p. 2905-2922 18 p., gkac122.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)485 Downloads (Pure) -
2021
A novel RNA Pol II CTD interaction site on the mRNA Capping Enzyme is essential for its allosteric activation
Bage, M. G. (Lead / Corresponding author), Almohammed, R., Cowling, V. H. & Pisliakov, A. V. (Lead / Corresponding author), 6 Apr 2021, In: Nucleic Acids Research. 49, 6, p. 3109-3126 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)125 Downloads (Pure) -
Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry
Pearson, L.-A., Green, C., Lin, D., Petit, A.-P., Gray, D. (Lead / Corresponding author), Cowling, V. & Fordyce, E. (Lead / Corresponding author), Jul 2021, In: SLAS Discovery. 26, 6, p. 749-756 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)126 Downloads (Pure) -
Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation
Galloway, A., Kaskar, A., Ditsova, D., Atrih, A., Yoshikawa, H., Gomez Moreira, C., Suska, O., Warminski, M., Grzela, R., Lamond, A. I., Darzynkiewicz, E., Jemielty, J. & Cowling, V. H. (Lead / Corresponding author), 9 Jul 2021, In: Nucleic Acids Research. 49, 12, p. 6722-6738 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)165 Downloads (Pure) -
2020
CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures
Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. (Lead / Corresponding author) & Cowling, V. H. (Lead / Corresponding author), 26 Feb 2020, In: Open Biology. 10, 2, 13 p., 190306.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)329 Downloads (Pure) -
Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity
Kasprzyk, R., Fido, M., Mamot, A., Wanat, P., Smietanski, M., Kopcial, M., Cowling, V. H., Kowalska, J. (Lead / Corresponding author) & Jemielity, J. (Lead / Corresponding author), 1 Sept 2020, In: Chemistry: a European Journal. 26, 49, p. 11266-11275 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)206 Downloads (Pure) -
The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts
Culjkovic-Kraljacic, B., Skrabanek, L., Revuelta, M. V., Gasiorek, J., Cowling, V. H., Cerchietti, L. & Borden, K. L. B. (Lead / Corresponding author), 27 Oct 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 43, p. 26773-26783 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)117 Downloads (Pure) -
2019
CAPAM: the mRNA cap adenosine N6 methyltransferase
Cowling, V. (Lead / Corresponding author), 1 Mar 2019, In: Trends in Biochemical Sciences. 44, 3, p. 183-185 3 p., 1545.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)193 Downloads (Pure) -
Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations
Bueren-Calabuig, J. (Lead / Corresponding author), Bage, M., Cowling, V. & Pisliakov, A. (Lead / Corresponding author), 19 Sept 2019, In: Nucleic Acids Research. 47, 16, p. 8675-8692 18 p., gkz613.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)156 Downloads (Pure) -
Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells
Dunn, S., Lombardi, O., Lukoszek, R. & Cowling, V. (Lead / Corresponding author), Apr 2019, In: Open Biology. 9, 4, p. 1-15 15 p., 190052.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)391 Downloads (Pure) -
2018
DHX15 regulates CMTR1-dependent gene expression and cell proliferation
Inesta-Vaquera, F., Chaugule, V. K., Galloway, A., Chandler, L., Rojas-Fernandez, A., Weidlich, S., Peggie, M. & Cowling, V. (Lead / Corresponding author), 18 Jun 2018, In: Life Science Alliance. 1, 3, 18 p., e201800092.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)236 Downloads (Pure) -
mRNA cap methyltransferase, RNMT-RAM, promotes RNA pol II-dependent transcription
Varshney, D., Lombardi, O., Schweikert, G., Dunn, S., Suska, O. & Cowling, V. (Lead / Corresponding author), May 2018, In: Cell Reports. 23, 5, p. 1530-1542 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile33 Citations (Scopus)285 Downloads (Pure) -
Positioning Europe for the EPITRANSCRIPTOMICS challenge
Jantsch, M. (Lead / Corresponding author), Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J.-Y., Balatsos, N., Dinnyes, A., Baranov, P. & Kelly, V. & 40 others, , 3 Jun 2018, In: RNA Biology. 15, 6, p. 829-831 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)260 Downloads (Pure) -
The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei
Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. (Lead / Corresponding author) & Ferguson, M. (Lead / Corresponding author), 24 Jul 2018, In: PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)157 Downloads (Pure) -
2017
c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production
Dunn, S., Lombardi, O. & Cowling, V., 20 Jan 2017, In: Biochemical Journal. 474, 3, p. 377-384 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)211 Downloads (Pure) -
2016
CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription
Aregger, M., Kaskar, A., Varshney, D., Fernandez-Sanchez, M. E., Inesta-Vaquera, F. A., Weidlich, S. & Cowling, V. H. (Lead / Corresponding author), 3 Mar 2016, In: Molecular Cell. 61, 5, p. 734-746 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)218 Downloads (Pure) -
c-Myc deregulation induces mRNA capping enzyme dependency
Lombardi, O., Varshney, D., Phillips, N. M. & Cowling, V. H. (Lead / Corresponding author), 16 Oct 2016, In: Oncotarget. 7, 50, p. 82273-82288 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)229 Downloads (Pure) -
Human IFIT1 inhibits mRNA translation of rubulaviruses but not other members of the Paramyxoviridae family
Young, D. F., Andrejeva, J., Li, X., Inesta-Vaquera, F., Dong, C., Cowling, V. H., Goodbourn, S. & Randall, R. E. (Lead / Corresponding author), 15 Oct 2016, In: Journal of Virology. 90, 20, p. 9446-9456 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)217 Downloads (Pure) -
Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM
Varshney, D., Petit, A.-P., Bueren-Calabuig, J. A., Jansen, C., Fletcher, D. A., Peggie, M., Weidlich, S., Scullion, P., Pisliakov, A. V. & Cowling, V. H. (Lead / Corresponding author), 1 Dec 2016, In: Nucleic Acids Research. 44, 21, p. 10423-10436 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile53 Citations (Scopus)443 Downloads (Pure) -
mRNA Cap methylation in pluripotency and differentiation
Grasso, L., Suska, O., Davidson, L., Gonatopoulos-Pournatzis, T., Williamson, R., Wasmus, L., Wiedlich, S., Peggie, M., Stavridis, M. P. & Cowling, V. H. (Lead / Corresponding author), 2 Aug 2016, In: Cell Reports. 16, 5, p. 1352-1365 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)239 Downloads (Pure) -
2015
Myc and mRNA capping
Dunn, S. & Cowling, V. H. (Lead / Corresponding author), May 2015, In: BBA - Gene Regulatory Mechanisms. 1849, 5, p. 501-505 5 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation
Varshney, D. (Lead / Corresponding author), Vavrova-Anderson, J., Oler, A. J., Cowling, V. H., Cairns, B. R. & White, R. J. (Lead / Corresponding author), 23 Mar 2015, In: Nature Communications. 6, 12 p., 6569.Research output: Contribution to journal › Article › peer-review
Open Access71 Citations (Scopus) -
Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes
Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M., Ferrero, I., MacDonald, H. R., Cowling, V. H. & Cantrell, D. A. (Lead / Corresponding author), 4 Aug 2015, In: EMBO Journal. 34, 15, p. 2008-2024 17 p.Research output: Contribution to journal › Article › peer-review
Open Access133 Citations (Scopus) -
2014
Burkitt's lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis
Cowling, V. H., Turner, S. A. & Cole, M. D. (Lead / Corresponding author), 3 Jul 2014, In: Oncogene. 33, p. 3519–3527 9 p.Research output: Contribution to journal › Article › peer-review
45 Citations (Scopus) -
RAM function is dependent on Kapβ2-mediated nuclear entry
Gonatopoulos-Pournatzis, T. & Cowling, V. H., 1 Feb 2014, In: Biochemical Journal. 457, 3, p. 473-484 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)184 Downloads (Pure)