Investigation of the Target of Metformin

Project Details

StatusFinished
Effective start/end date1/05/1330/04/16

Funding

  • Medical Research Council (MR/K012924/1): £356,769.00

Research Output

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

Maack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J-S., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J., Bayes-Genis, A., Brutsaert, D., Bugger, H., Clarke, K., Cosentino, F., De Keulenaer, G., Dei Cas, A., González, A., Huelsmann, M., Iaccarino, G. & 15 others, Lunde, I. G., Lyon, A. R., Pollesello, P., Rena, G., Riksen, N. P., Rosano, G., Staels, B., van Laake, L. W., Wanner, C., Farmakis, D., Filippatos, G., Ruschitzka, F., Seferovic, P., de Boer, R. A. & Heymans, S., 21 Dec 2018, In : European Heart Journal. 39, 48, p. 4243-4254 12 p., ehy596.

Research output: Contribution to journalArticle

Open Access
File
  • 56 Citations (Scopus)
    185 Downloads (Pure)

    Metformin selectively targets redox control of complex I energy transduction

    Cameron, A., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J., Kerr, C., Curry, H., Stewart, D., Sakamoto, K., Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In : Redox Biology. 14, p. 187-197 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 54 Citations (Scopus)
    161 Downloads (Pure)

    Regulation of hepatic glucose production and AMPK by AICAR but not by metformin depends on drug uptake through the equilibrative nucleoside transporter 1 (ENT1)

    Logie, L., Lees, Z., Allwood, J. W., McDougall, G., Beall, C. & Rena, G., Dec 2018, In : Diabetes, Obesity & Metabolism. 20, 12, p. 2748-2758 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 4 Citations (Scopus)
    172 Downloads (Pure)