Keratinizing Skin Disorder: From Systems Biology to Targeted Therapeutics (New Investigator Award)

  • Leslie Pedrioli, Deena (Investigator)

Project Details

StatusFinished
Effective start/end date1/07/1430/06/17

Funding

  • Medical Research Council (MR/L020246/1): £121,923.61

Research Output

CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting

Courtney, D. G., Moore, J. E., Atkinson, S. D., Maurizi, E., Allen, E. H. A., Leslie Pedrioli, D. M. L., Mclean, W. H. I., Nesbit, M. A. & Moore, C. B. T., 2016, In : Gene Therapy. 23, 1, p. 108-112

Research output: Contribution to journalArticle

Open Access
File
  • 56 Citations (Scopus)
    138 Downloads (Pure)

    Keratin 12 missense mutation induces the unfolded protein response and apoptosis in meesmann epithelial corneal dystrophy

    Allen, E. H. A., Courtney, D. G., Atkinson, S. D., Moore, J. E., Mairs, L., Poulsen, E. T., Schiroli, D., Maurizi, E., Cole, C., Hickerson, R. P., James, J., Murgatroyd, H., Smith, F. J. D., MacEwen, C., Enghild, J. J., Nesbit, M. A., Leslie Pedrioli, D. M., McLean, W. H. I. & Moore, C. B. T., 15 Mar 2016, In : Human Molecular Genetics. 25, 6, p. 1176-1191 16 p., ddw001.

    Research output: Contribution to journalArticle

    Open Access
    File
  • 5 Citations (Scopus)
    144 Downloads (Pure)
    Open Access
    File
  • 29 Citations (Scopus)
    149 Downloads (Pure)