Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands (Sir Henry Dale Fellowship)

Crocker, Paul (Investigator)
Moraga Gonzalez, Ignacio (Investigator)

Cell Signalling and Immunology

Status	Finished
Effective start/end date	1/09/16 → 31/08/22

Funding

Wellcome Trust (202323/Z/16/Z): £27,763.90
Wellcome Trust (202323/Z/16/Z): £1,075,036.90

6 Article
1 Review article

Molecular and cellular factors determining the functional pleiotropy of cytokines
McFarlane, A., Pohler, E. & Moraga, I., May 2023, In: FEBS Journal. 290, 10, p. 2525-2552 28 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
2 Citations (Scopus)

52 Downloads (Pure)
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R., Moraga, I., & 1 othersMitra, S., 2 Dec 2022, In: Science Immunology. 7, 78, 15 p., eade568.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

285 Downloads (Pure)
Structural insights into the assembly and activation of the IL-27 signaling complex
Jin, Y., Fyfe, P. K., Gardner, S., Wilmes, S., Bubeck, D. & Moraga, I., 6 Oct 2022, In: EMBO Reports. 23, 10, 10 p., e55450.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

70 Downloads (Pure)