Research output per year
Research output per year
Search results
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2024
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency
Gardner, S., Jin, Y., Fyfe, P. K., Voisin, T. B., Sotolongo Bellón, J., Pohler, E., Piehler, J., Moraga, I. (Lead / Corresponding author) & Bubeck, D. (Lead / Corresponding author), 7 Mar 2024, In: Nature Communications. 15, 11 p., 2071.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)82 Downloads (Pure) -
2023
Molecular and cellular factors determining the functional pleiotropy of cytokines
McFarlane, A., Pohler, E. & Moraga, I. (Lead / Corresponding author), May 2023, In: FEBS Journal. 290, 10, p. 2525-2552 28 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)170 Downloads (Pure) -
2022
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein
Gaggero, S., Martinez-Fabregas, J., Cozzani, A., Fyfe, P. K., Leprohon, M., Yang, J., Thomasen, F. E., Winkelmann, H., Magnez, R., Conti, A. G., Wilmes, S., Pohler, E., van Gijsel Bonnello, M., Thuru, X., Quesnel, B., Soncin, F., Piehler, J., Lindorff-Larsen, K., Roychoudhuri, R. (Lead / Corresponding author) & Moraga, I. (Lead / Corresponding author) & 1 others, , 2 Dec 2022, In: Science Immunology. 7, 78, 15 p., eade568.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)896 Downloads (Pure) -
Structural insights into the assembly and activation of the IL-27 signaling complex
Jin, Y., Fyfe, P. K., Gardner, S., Wilmes, S., Bubeck, D. (Lead / Corresponding author) & Moraga, I. (Lead / Corresponding author), 6 Oct 2022, In: EMBO Reports. 23, 10, 10 p., e55450.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)181 Downloads (Pure) -
2021
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses
Wilmes, S., Jeffrey, P.-A., Martinez-Fabregas, J., Hafer, M., Fyfe, P. K., Pohler, E., Gaggero, S., Lopez-Garcia, M., Lythe, G., Taylor, C., Guerrier, T., Launay, D., Mitra, S., Piehler, J., Molina-Paris, C. (Lead / Corresponding author) & Moraga Gonzalez, I. (Lead / Corresponding author), 5 May 2021, In: eLife. 10, 44 p., e66014.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)196 Downloads (Pure) -
Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis
Martinez-Fabregas, J. (Lead / Corresponding author), Pohler, E. & Moraga, I. (Lead / Corresponding author), 18 Jun 2021, In: STAR Protocols. 2, 2, 14 p., 100417.Research output: Contribution to journal › Article › peer-review
Open AccessFile139 Downloads (Pure) -
2020
CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
Martinez-Fabregas, J., Wang, L., Pohler, E., Cozzani, A., Wilmes, S., Kazemian, M. (Lead / Corresponding author), Mitra, S. (Lead / Corresponding author) & Moraga, I. (Lead / Corresponding author), 22 Dec 2020, In: Cell Reports. 33, 12, 26 p., 108545.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)307 Downloads (Pure) -
2019
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
Martinez-Fabregas, J., Wilmes, S., Wang, L., Hafer, M., Pohler, E., Lokau, J., Garbers, C., Cozzani, A., Piehler, J., Kazemian, M. (Lead / Corresponding author), Mitra, S. (Lead / Corresponding author) & Moraga Gonzalez, I., 27 Nov 2019, In: eLife. 8, p. 1-32 32 p., e49314.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)185 Downloads (Pure)