MASTER MIND - MRC ABPI Stratification and Extreme Response Mechanism in Type 2 Diabetes (Joint with University of Exeter, Newcastle University, Kings College London, University of Oxford and University of Glasgow) - Research Outputs - Discovery

2025

A five-drug class model using routinely available clinical features to optimise prescribing in type 2 diabetes: a prediction model development and validation study

Dennis, J. M. (Lead / Corresponding author), Young, K. G., Cardoso, P., Güdemann, L. M., McGovern, A. P., Farmer, A., Holman, R. R., Sattar, N., McKinley, T. J., Pearson, E. R., Jones, A. G., Shields, B. M. & Hattersley, A. T., 25 Feb 2025, (E-pub ahead of print) In: The Lancet. 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Phenotype-based targeted treatment of SGLT2 inhibitors and GLP-1 receptor agonists in type 2 diabetes

Cardoso, P., Young, K. G., Nair, A. T. N., Hopkins, R., McGovern, A. P., Haider, E., Karunaratne, P., Donnelly, L., Mateen, B. A., Sattar, N., Holman, R. R., Bowden, J., Hattersley, A. T., Pearson, E. R., Jones, A. G., Shields, B. M., McKinley, T. J., Dennis, J. M. (Lead / Corresponding author) & MASTERMIND consortium, May 2024, In: Diabetologia. 67, 5, p. 822-836 15 p.

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Open Access

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7 Citations (Scopus)

74 Downloads (Pure)

Safety and effectiveness of SGLT2 inhibitors in a UK population with type 2 diabetes and aged over 70 years: an instrumental variable approach

Güdemann, L. M. (Lead / Corresponding author), Young, K. G., Thomas, N. J. M., Hopkins, R., Challen, R., Jones, A. G., Hattersley, A. T., Pearson, E. R., Shields, B. M., Bowden, J., Dennis, J. M., McGovern, A. P. & MASTERMIND consortium, Sept 2024, In: Diabetologia. 67, 9, p. 1817-1827 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

66 Downloads (Pure)

2023

Patient preference for second- and third-line therapies in type 2 diabetes: a prespecified secondary endpoint of the TriMaster study

Shields, B. M., Angwin, C. D., Shepherd, M. H., Britten, N., Jones, A. G., Sattar, N., Holman, R., Pearson, E. R. & Hattersley, A. T. (Lead / Corresponding author), Feb 2023, In: Nature Medicine. 29, p. 384–391 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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11 Citations (Scopus)

109 Downloads (Pure)

Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

Shields, B. M., Dennis, J. M., Angwin, C. D., Warren, F., Henley, W. E., Farmer, A. J., Sattar, N., Holman, R. R., Jones, A. G., Pearson, E. R., Hattersley, A. T. (Lead / Corresponding author) & TriMaster Study group, Feb 2023, In: Nature Medicine. 29, p. 376–383 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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34 Citations (Scopus)

271 Downloads (Pure)

2020

Risk of anemia with metformin use in type 2 diabetes: A MASTERMIND study

Donnelly, L. A., Dennis, J. M., Coleman, R. L., Sattar, N., Hattersley, A. T., Holman, R. R. & Pearson, E. R. (Lead / Corresponding author), Oct 2020, In: Diabetes Care. 43, 10, p. 2493-2499 7 p.

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Open Access

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43 Citations (Scopus)

316 Downloads (Pure)

TriMaster: Randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea - A MASTERMIND study protocol

Angwin, C., Jenkinson, C., Jones, A., Jennison, C., Henley, W., Farmer, A., Sattar, N., Holman, R. R., Pearson, E., Shields, B. (Lead / Corresponding author) & Hattersley, A., Dec 2020, In: BMJ Open. 10, 12, 10 p., e042784.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

107 Downloads (Pure)

2019

Time trends in prescribing of type 2 diabetes drugs, glycaemic response and risk factors: a retrospective analysis of primary care data, 2010-2017

Dennis, J. M., Henley, W. E., McGovern, A. P., Farmer, A. J., Sattar, N., Holman, R. R., Pearson, E. R., Hattersley, A. T., Shields, B. M. (Lead / Corresponding author), Jones, A. G. (Lead / Corresponding author) & MASTERMIND consortium, Jul 2019, In: Diabetes, Obesity & Metabolism. 21, 7, p. 1576-1584 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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67 Citations (Scopus)

273 Downloads (Pure)

What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? A MASTERMIND study

MASTERMIND consortium, McGovern, A. P. (Lead / Corresponding author), Dennis, J. M., Shields, B. M., Hattersley, A. T., Pearson, E. R. & Jones, A. G., 12 Apr 2019, In: BMC Medicine. 17, 1, p. 1-17 17 p., 79.

Research output: Contribution to journal › Article › peer-review

Open Access

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21 Citations (Scopus)

190 Downloads (Pure)

MASTER MIND - MRC ABPI Stratification and Extreme Response Mechanism in Type 2 Diabetes (Joint with University of Exeter, Newcastle University, Kings College London, University of Oxford and University of Glasgow)

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