Research output per year
Research output per year
- 28 results
Search results
-
2018
Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation
Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D. (Lead / Corresponding author), Nov 2018, In: PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)175 Downloads (Pure) -
Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome
Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T. (Lead / Corresponding author), 6 Aug 2018, In: eLife. 2018, 7, p. 1-28 28 p., e35720.Research output: Contribution to journal › Article › peer-review
Open AccessFile55 Citations (Scopus)248 Downloads (Pure) -
2016
Establishment of a promoter based chromatin architecture on recently replicated DNA can accommodate variable internucleosome spacing
Fennessy, R. T. & Owen-Hughes, T. (Lead / Corresponding author), 6 Sept 2016, In: Nucleic Acids Research. 44, 15, p. 7189-7203 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Citations (Scopus)239 Downloads (Pure) -
High resolution imaging reveals heterogeneity in chromatin states between cells that is not inherited through cell division
Dickerson, D., Gierlinski, M., Singh, V., Kitamura, E., Ball, G., Tanaka, T. U. & Owen-Hughes, T. (Lead / Corresponding author), 8 Sept 2016, In: BMC Cell Biology. 17, 16 p., 33.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)252 Downloads (Pure) -
How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?
Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G. G. (Lead / Corresponding author), Owen-Hughes, T. (Lead / Corresponding author), Blaxter, M. (Lead / Corresponding author) & Barton, G. J. (Lead / Corresponding author), Jun 2016, In: RNA: a Publication of the RNA Society. 22, 6, p. 839-851 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile523 Citations (Scopus)411 Downloads (Pure) -
The chromatin remodelling enzymes SNF2H and SNF2L position nucleosomes adjacent to CTCF and other transcription
Wiechens, N. (Lead / Corresponding author), Singh, V., Gkikopoulos, T., Schofield, P., Rocha, S. & Owen-Hughes, T., 28 Mar 2016, In: PLoS Genetics. 12, 3, e1005940.Research output: Contribution to journal › Article › peer-review
Open AccessFile75 Citations (Scopus)264 Downloads (Pure) -
2015
Statistical models for RNA-seq data derived from a two-condition 48-replicate experiment
Gierlinski, M., Cole, C., Schofield, P., Schurch, N. J., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., 15 Nov 2015, In: Bioinformatics. 31, 22, p. 3625-3630 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Citations (Scopus)239 Downloads (Pure) -
2014
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
Di Cerbo, V., Mohn, F., Ryan, D. P., Montellier, E., Kacem, S., Tropberger, P., Kallis, E., Holzner, M., Hoerner, L., Feldmann, A., Richter, F. M., Bannister, A. J., Mittler, G., Michaelis, J., Khochbin, S., Feil, R., Schuebeler, D., Owen-Hughes, T., Daujat, S. (Lead / Corresponding author) & Schneider, R. (Lead / Corresponding author), 25 Mar 2014, In: eLife. 3, e01632.Research output: Contribution to journal › Article › peer-review
Open AccessFile93 Citations (Scopus)500 Downloads (Pure) -
Modelling multi-protein complexes using PELDOR distance measurements for rigid body minimisation experiments using XPLOR-NIH
Hammond, C. M., Owen-Hughes, T. (Lead / Corresponding author) & Norman, D. G. (Lead / Corresponding author), Dec 2014, In: Methods (San Diego, Calif.). 70, 2-3, p. 139-153 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)226 Downloads (Pure) -
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
Bowman, A., Hammond, C. M., Stirling, A., Ward, R., Shang, W., El-Mkami, H., Robinson, D. A., Svergun, D. I., Norman, D. G. & Owen-Hughes, T. (Lead / Corresponding author), 2014, In: Nucleic Acids Research. 42, 9, p. 6038-6051 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)249 Downloads (Pure) -
The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement
El Mkami, H., Ward, R., Bowman, A., Owen-Hughes, T. & Norman, D. G. (Lead / Corresponding author), Nov 2014, In: Journal of Magnetic Resonance . 248, p. 36-41 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)218 Downloads (Pure) -
2013
A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones
Allan, J., Fraser, R. M., Owen-Hughes, T., Docherty, K. & Singh, V., 15 Nov 2013, In: Journal of Molecular Biology. 425, 22, p. 4206-4222 17 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
CENP-A confers a reduction in height on octameric nucleosomes
Miell, M. D. D., Barysz, H. M., Rappsilber, J., Allshire, R. C., Fuller, C. J., Straight, A. F., Guse, A., Downes, A. & Owen-Hughes, T., 2013, In: Nature Structural & Molecular Biology.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes
Narlikar, G. J., Sundaramoorthy, R. & Owen-Hughes, T., 2013, In: Cell. 154, 3, p. 490-503 14 p.Research output: Contribution to journal › Article › peer-review
477 Citations (Scopus) -
PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA
Biebricher, A., Hirano, S., Enzlin, J. H., Wiechens, N., Streicher, W. W., Huttner, D., Wang, L. H. C., Nigg, E. A., Owen-Hughes, T., Liu, Y., Peterman, E., Wuite, G. J. L. & Hickson, I. D. (Lead / Corresponding author), 12 Sept 2013, In: Molecular Cell. 51, 5, p. 691-701 11 p.Research output: Contribution to journal › Article › peer-review
77 Citations (Scopus) -
Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1
Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E. (Lead / Corresponding author), Jan 2013, In: Nature Structural & Molecular Biology. 20, 1, p. 29-35 7 p.Research output: Contribution to journal › Article › peer-review
55 Citations (Scopus) -
2012
Making sense of transcribing chromatin
Owen-Hughes, T. & Gkikopoulos, T., 1 Jan 2012, In: Current Opinion in Cell Biology.Research output: Contribution to journal › Article › peer-review
23 Citations (Scopus) -
Micrococcal Nuclease Does Not Substantially Bias Nucleosome Mapping
Allan, J., Fraser, R. M., Owen-Hughes, T. & Keszenman-Pereyra, D., 30 Mar 2012, In: Journal of Molecular Biology. 417, 3, p. 152-164 13 p.Research output: Contribution to journal › Article › peer-review
File64 Citations (Scopus)254 Downloads (Pure) -
Sulfyhydryl-reactive site-directed cross-linking as a method for probing the tetrameric structure of histones H3 and H4
Bowman, A. & Owen-Hughes, T., 2012, Chromatin remodeling: methods and protocols. Morse, R. H. (ed.). Humana Press, p. 373-387 15 p. (Methods in Molecular Biology; vol. 833).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed)
3 Citations (Scopus) -
The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4
Watson, A. A., Mahajan, P., Mertens, H. D. T., Deery, M. J., Zhang, W., Chen, Y., Edlich, C., Laue, E. D., Berridge, G., Burgess-Brown, N. A., Gileadi, O., Svergun, D. I., Pham, P., Du, X., Bartke, T., Kouzarides, T., Wiechens, N. & Owen-Hughes, T., 2012, In: Journal of Molecular Biology. 422, 1, p. 3-17 15 p.Research output: Contribution to journal › Article › peer-review
60 Citations (Scopus) -
2011
A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization
Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T. (Lead / Corresponding author), 23 Sept 2011, In: Science. 333, 6050, p. 1758-1760 3 p.Research output: Contribution to journal › Article › peer-review
227 Citations (Scopus) -
DNA repair factor APLF is a histone chaperone
Mehrotra, P. V., Ahel, D., Ryan, D. P., Weston, R., Wiechens, N., Kraehenbuehl, R., Owen-Hughes, T. & Ahel, I., 7 Jan 2011, In: Molecular Cell. 41, 1, p. 46-55 10 p.Research output: Contribution to journal › Article › peer-review
137 Citations (Scopus) -
Mechanisms for ATP-dependent chromatin remodelling: the means to the end
Flaus, A. & Owen-Hughes, T., Oct 2011, In: FEBS Journal. 278, 19, p. 3579-3595 17 p.Research output: Contribution to journal › Review article › peer-review
95 Citations (Scopus) -
Snf2-family proteins: chromatin remodellers for any occasion
Ryan, D. P. & Owen-Hughes, T., Oct 2011, In: Current Opinion in Chemical Biology. 15, 5, p. 649-656 8 p.Research output: Contribution to journal › Review article › peer-review
102 Citations (Scopus) -
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains
Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T. (Lead / Corresponding author), 6 Jul 2011, In: EMBO Journal. 30, 13, p. 2596-2609 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile100 Citations (Scopus)228 Downloads (Pure) -
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation
Bowman, A., Ward, R., Wiechens, N., Singh, V., El-Mkami, H., Norman, D. G. & Owen-Hughes, T. (Lead / Corresponding author), 18 Feb 2011, In: Molecular Cell. 41, 4, p. 398-408 11 p.Research output: Contribution to journal › Article › peer-review
File69 Citations (Scopus)250 Downloads (Pure) -
The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4
Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T. (Lead / Corresponding author), 18 May 2011, In: EMBO Journal. 30, 10, p. 1919-1927 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)203 Downloads (Pure) -
2003
Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities
Bruno, M., Flaus, A., Stockdale, C., Rencurel, C., Ferreira, H. & Owen-Hughes, T., 2003, In: Molecular Cell. 12, 6, p. 1599-1606 8 p.Research output: Contribution to journal › Article › peer-review
166 Citations (Scopus)