Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.

Research Output

Antiparasitic chemotherapy: from genomes to mechanisms

Horn, D. & Duraisingh, M. T., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

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36 Citations (Scopus)
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144 Citations (Scopus)
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Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Jeacock, L., Baker, N., Wiedemar, N., Mäser, P. & Horn, D., 30 Mar 2017, In : PLoS Pathogens. 13, 3, p. 1-16 16 p., e1006307.

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16 Citations (Scopus)
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Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

Graf, F. E., Ludin, P., Wenzler, T., Kaiser, M., Brun, R., Pyana, P. P., Büscher, P., de Koning, H. P., Horn, D. & Mäser, P., 10 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, p. 1-7 7 p., e2475.

Research output: Contribution to journalArticle

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47 Citations (Scopus)
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Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. & Mäser, P., Aug 2015, In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 2, p. 65-68 4 p.

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30 Citations (Scopus)
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Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Graf, F. E., Ludin, P., Arquint, C., Schmidt, R. S., Schaub, N., Kunz Renggli, C., Munday, J. C., Krezdorn, J., Baker, N., Horn, D., Balmer, O., Caccone, A., de Koning, H. P. & Mäser, P., Sep 2016, In : Cellular and Molecular Life Sciences. 73, 17, p. 3387-3400 14 p.

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17 Citations (Scopus)
148 Downloads (Pure)

Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Zoltner, M., Horn, D., de Koning, H. P. & Field, M. C., Dec 2016, In : Current Opinion in Microbiology. 34, p. 97-103 7 p.

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14 Citations (Scopus)
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How Antiparasitic Drugs Work-And Sometimes Stop Working!

Horn, D., 5 May 2016, In : PLoS Pathogens. 12, 5, p. 1-3 3 p., e1005430.

Research output: Contribution to journalArticle

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Melarsoprol Resistance in African Trypanosomiasis

Fairlamb, A. & Horn, D., Jun 2018, In : Trends in Parasitology. 34, 6, p. 481-492 12 p.

Research output: Contribution to journalReview article

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20 Citations (Scopus)
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Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. & Beitz, E., 1 Feb 2016, In : PLoS Pathogens. 12, 2, 14 p., e1005436.

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33 Citations (Scopus)
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Receptor-mediated endocytosis for drug delivery in African trypanosomes: Fulfilling Paul Ehrlich's vision of chemotherapy

Alsford, S., Field, M. C. & Horn, D., May 2013, In : Trends in Parasitology. 29, 5, p. 207-212 6 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P., 1 Mar 2014, In : Journal of Antimicrobial Chemotherapy. 69, 3, p. 651-663 13 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)