Research output per year
Research output per year
- 14 results
Search results
-
2019
Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei
Collett, C. F., Kitson, C., Baker, N., Steele-Stallard, H. B., Santrot, M.-V., Hutchinson, S., Horn, D. & Alsford, S. (Lead / Corresponding author), Aug 2019, In: Antimicrobial Agents and Chemotherapy. 63, 8, p. 1-19 19 p., e00795-19.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Link opens in a new tab Citations (Scopus)173 Downloads (Pure) -
2018
Insights into antitrypanosomal drug mode-of-action from cytology-based profiling
Thomas, J., Baker, N., Dominicus, C., Trenaman, A., Glover, L., Alsford, S. & Horn, D. (Lead / Corresponding author), 26 Nov 2018, In: PLoS Neglected Tropical Diseases. 12, 11, p. 1-19 19 p., e0006980.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Link opens in a new tab Citations (Scopus)260 Downloads (Pure) -
2017
Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity
Jeacock, L., Baker, N., Wiedemar, N., Mäser , P. & Horn, D. (Lead / Corresponding author), 30 Mar 2017, In: PLoS Pathogens. 13, 3, p. 1-16 16 p., e1006307.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Link opens in a new tab Citations (Scopus)255 Downloads (Pure) -
2016
Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense
Graf, F. E., Ludin, P., Arquint, C., Schmidt, R. S., Schaub, N., Kunz Renggli, C., Munday, J. C., Krezdorn, J., Baker, N., Horn, D., Balmer, O., Caccone, A., de Koning, H. P. & Mäser, P. (Lead / Corresponding author), Sept 2016, In: Cellular and Molecular Life Sciences. 73, 17, p. 3387-3400 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Link opens in a new tab Citations (Scopus)231 Downloads (Pure) -
Exploiting the Achilles' heel of membrane trafficking in trypanosomes
Zoltner, M., Horn, D., de Koning, H. P. & Field, M. C. (Lead / Corresponding author), Dec 2016, In: Current Opinion in Microbiology. 34, p. 97-103 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Link opens in a new tab Citations (Scopus)230 Downloads (Pure) -
How Antiparasitic Drugs Work-And Sometimes Stop Working!
Horn, D. (Lead / Corresponding author), 5 May 2016, In: PLoS Pathogens. 12, 5, p. 1-3 3 p., e1005430.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Link opens in a new tab Citation (Scopus)263 Downloads (Pure) -
Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2
Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. & Beitz, E. (Lead / Corresponding author), 1 Feb 2016, In: PLoS Pathogens. 12, 2, 14 p., e1005436.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Link opens in a new tab Citations (Scopus)207 Downloads (Pure) -
2015
Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates
Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. & Mäser, P. (Lead / Corresponding author), Aug 2015, In: International Journal for Parasitology: Drugs and Drug Resistance. 5, 2, p. 65-68 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Link opens in a new tab Citations (Scopus)283 Downloads (Pure) -
Modulation of the surface proteome through multiple ubiquitylation pathways in African Trypanosomes
Zoltner, M., Leung, K. F., Alsford, S., Horn, D. & Field, M. C. (Lead / Corresponding author), 22 Oct 2015, In: PLoS Pathogens. 11, 10, 26 p., e1005236.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Link opens in a new tab Citations (Scopus)344 Downloads (Pure) -
2014
Antiparasitic chemotherapy: from genomes to mechanisms
Horn, D. & Duraisingh, M. T., Jan 2014, In: Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.Research output: Contribution to journal › Article › peer-review
56 Link opens in a new tab Citations (Scopus) -
High-throughput decoding of drug targets and drug resistance mechanisms in African trypanosomes
Horn, D. (Lead / Corresponding author), Jan 2014, In: Parasitology. 141, 1, p. 77-82 6 p.Research output: Contribution to journal › Article › peer-review
9 Link opens in a new tab Citations (Scopus) -
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P. (Lead / Corresponding author), 1 Mar 2014, In: Journal of Antimicrobial Chemotherapy. 69, 3, p. 651-663 13 p.Research output: Contribution to journal › Article › peer-review
120 Link opens in a new tab Citations (Scopus) -
2013
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Graf, F. E., Ludin, P., Wenzler, T., Kaiser, M., Brun, R., Pyana, P. P., Büscher, P., de Koning, H. P., Horn, D. & Mäser, P. (Lead / Corresponding author), 10 Oct 2013, In: PLoS Neglected Tropical Diseases. 7, 10, p. 1-7 7 p., e2475.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Link opens in a new tab Citations (Scopus)212 Downloads (Pure) -
Genetic dissection of drug resistance in trypanosomes
Alsford, S. (Lead / Corresponding author), Kelly, J. M., Baker, N. & Horn, D., Oct 2013, In: Parasitology. 140, 12, p. 1478-1491 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Link opens in a new tab Citations (Scopus)85 Downloads (Pure)