Melarsoprol-Pentamidine Cross Resistance in African Trypanosomes.

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2017

Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Jeacock, L., Baker, N., Wiedemar, N., Mäser, P. & Horn, D., 30 Mar 2017, In : PLoS Pathogens. 13, 3, p. 1-16 16 p., e1006307.

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14 Citations (Scopus)
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2016

Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense

Graf, F. E., Ludin, P., Arquint, C., Schmidt, R. S., Schaub, N., Kunz Renggli, C., Munday, J. C., Krezdorn, J., Baker, N., Horn, D., Balmer, O., Caccone, A., de Koning, H. P. & Mäser, P., Sep 2016, In : Cellular and Molecular Life Sciences. 73, 17, p. 3387-3400 14 p.

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16 Citations (Scopus)
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Exploiting the Achilles' heel of membrane trafficking in trypanosomes

Zoltner, M., Horn, D., de Koning, H. P. & Field, M. C., Dec 2016, In : Current Opinion in Microbiology. 34, p. 97-103 7 p.

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12 Citations (Scopus)
135 Downloads (Pure)

How Antiparasitic Drugs Work-And Sometimes Stop Working!

Horn, D., 5 May 2016, In : PLoS Pathogens. 12, 5, p. 1-3 3 p., e1005430.

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Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2

Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. & Beitz, E., 1 Feb 2016, In : PLoS Pathogens. 12, 2, 14 p., e1005436.

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31 Citations (Scopus)
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2015

Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates

Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. & Mäser, P., Aug 2015, In : International Journal for Parasitology: Drugs and Drug Resistance. 5, 2, p. 65-68 4 p.

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28 Citations (Scopus)
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2014

Antiparasitic chemotherapy: from genomes to mechanisms

Horn, D. & Duraisingh, M. T., Jan 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 71-94 24 p.

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35 Citations (Scopus)

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs

Munday, J. C., Eze, A. A., Baker, N., Glover, L., Clucas, C., Andrés, D. A., Natto, M. J., Teka, I. A., McDonald, J., Lee, R. S., Graf, F. E., Ludin, P., Burchmore, R. J. S., Turner, C. M. R., Tait, A., MacLeod, A., Mäser, P., Barrett, M. P., Horn, D. & De Koning, H. P., 1 Mar 2014, In : Journal of Antimicrobial Chemotherapy. 69, 3, p. 651-663 13 p.

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68 Citations (Scopus)
2013

Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol

Graf, F. E., Ludin, P., Wenzler, T., Kaiser, M., Brun, R., Pyana, P. P., Büscher, P., de Koning, H. P., Horn, D. & Mäser, P., 10 Oct 2013, In : PLoS Neglected Tropical Diseases. 7, 10, p. 1-7 7 p., e2475.

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45 Citations (Scopus)
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